Keratinocyte differentiation mediated by IL-22

• Project/Area Number: 25461697
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Ehime University
• Principal Investigator: Tohyama Mikiko 愛媛大学, 医学(系)研究科(研究院), 准教授 (60263935)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 表皮角化細胞分化 / IL-22 / フィラグリン / k10 / IL-22R1 / アトピー性皮膚炎 / 乾癬 / 表皮角化細胞 / 分化 / 尋常性乾癬

Outline of Final Research Achievements

IL-22 plays important roles in the pathogenesis of atopic dermatitis and psoriasis vulgaris. IL-22 affects the differentiation of epidermal keratinocytes. The receptor for IL-22 is a complex of the IL-22R1 and IL-10R2. Expression levels of IL-22R1 increase in the epidermis of psoriasis, which induces strong STAT3 phosphorylation, but not in that of atopic dermatitis. We examined the influence of IL-22R1 expression levels on the regulation of differentiation marker expressions in keratinocytes treated with IL-22.