|Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|Outline of Final Research Achievements
IL-22 plays important roles in the pathogenesis of atopic dermatitis and psoriasis vulgaris. IL-22 affects the differentiation of epidermal keratinocytes. The receptor for IL-22 is a complex of the IL-22R1 and IL-10R2. Expression levels of IL-22R1 increase in the epidermis of psoriasis, which induces strong STAT3 phosphorylation, but not in that of atopic dermatitis. We examined the influence of IL-22R1 expression levels on the regulation of differentiation marker expressions in keratinocytes treated with IL-22.