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Keratinocyte differentiation mediated by IL-22

Research Project

Project/Area Number 25461697
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionEhime University

Principal Investigator

Tohyama Mikiko  愛媛大学, 医学(系)研究科(研究院), 准教授 (60263935)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords表皮角化細胞分化 / IL-22 / フィラグリン / k10 / IL-22R1 / アトピー性皮膚炎 / 乾癬 / 表皮角化細胞 / 分化 / 尋常性乾癬
Outline of Final Research Achievements

IL-22 plays important roles in the pathogenesis of atopic dermatitis and psoriasis vulgaris. IL-22 affects the differentiation of epidermal keratinocytes. The receptor for IL-22 is a complex of the IL-22R1 and IL-10R2. Expression levels of IL-22R1 increase in the epidermis of psoriasis, which induces strong STAT3 phosphorylation, but not in that of atopic dermatitis. We examined the influence of IL-22R1 expression levels on the regulation of differentiation marker expressions in keratinocytes treated with IL-22.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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