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A role for Langerhans cells in psoriasis: analysis of mouse model

Research Project

Project/Area Number 25461700
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionKochi University

Principal Investigator

Yamamoto Mayuko  高知大学, 教育研究部医療学系臨床医学部門, 助教 (20423478)

Co-Investigator(Kenkyū-buntansha) MAKAJIMA Kimiko  高知大学, 教育研究部医療学系臨床医学部門, 准教授 (20403892)
MAKAJIMA Hideki  高知大学, 教育研究部医療学系臨床医学部門, 講師 (70314995)
SANO Shigetoshi  高知大学, 教育研究部医療学系臨床医学部門, 教授 (80273621)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords尋常性乾癬 / ランゲルハンス細胞
Outline of Final Research Achievements

The aim of this study is to examine the role for Langerhans cells (LCs) in psoriasis. Compared with control mice, psoriasis-prone K5.Stat3C mice, whose keratinocytes exhibited active Stat3, showed increased number of langerin(+) cells in the skin-draining lymph nodes (SdLN), suggesting LCs with a tendency of emigration from the epidermis under the influence of Stat3 activated-keratinocytes. They developed psoriasis by topical TPA treatment, which further enhanced LC migration. Skin lesion was attenuated when LCs were inducibly depleted, strongly suggesting that LCs were essential for psoriasis development. There were increased number of IL-23 producing-LCs and other DCs in SdLN cells when treated with TPA. Collectively, our study indicates that Stat3 activation of keratinocytes lead to LC activation and emigration to SdLN, which process is essential for psoriasogenesis through producing cytokines such as IL-23.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (13 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] 乳癌治療の6年後に生じたradiation-induced morphea2016

    • Author(s)
      山本真有子、樽谷勝仁、佐野栄紀
    • Journal Title

      皮膚病診療

      Volume: 38 Pages: 177-180

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Psoriatic inflammation facilitates the onset of arthritis in a mouse model.2014

    • Author(s)
      Yamamoto M, Nakajima K, Takaishi M, Kitaba S, Magata Y, Kataoka S, Sano S
    • Journal Title

      J Invest Dermatol.

      Volume: 135 Issue: 2 Pages: 445-453

    • DOI

      10.1038/jid.2014.426

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of Schnitzler syndrome with cyclosporine.2014

    • Author(s)
      Nakajima K. Takahashi M, Yamamoto M, Takahashi A, Sano S, Kodama H, Arima K, Ida H.
    • Journal Title

      Int J Dermatol.

      Volume: 53 Issue: 7

    • DOI

      10.1111/ijd.12300

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cushing症候群に伴った色素性痒疹2014

    • Author(s)
      山本真有子、佐野栄紀、樽谷勝仁、田口崇文
    • Journal Title

      皮膚病診療

      Volume: 36 Pages: 841-844

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 骨髄異形成症候群(MDS)に伴った環状紅斑2016

    • Author(s)
      山本真有子、中島英貴、佐野栄紀、池野史典
    • Organizer
      第79回日本皮膚科学会東京・東部支部合同学術大会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2016-02-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] Langeruhans cells migrate to lymph nodes with increased number in mice with Stat3 actvation in epidermal keratino-cytes and are essential for development of psoriasis-like lesion2015

    • Author(s)
      Kimiko Nakajima, Kataoka S, Yamamoto M, Bernard M, Sano S
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] Langerhans cells migrate to lymph nodes with increased number in mice with Stat3 activation in epidermal2015

    • Author(s)
      Kimiko Nakajima, Sayo Kataoka, Mayuko Yamamoto, Bernard Malissen, Shigetoshi Sano
    • Organizer
      LC2015 14th International Workshop on Langerhans Cells
    • Place of Presentation
      Kyoto International Community House(京都)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗BP180抗体陽性であったbullous lichen planus2015

    • Author(s)
      山本真有子、中島喜美子、佐野栄紀、高橋 綾
    • Organizer
      第67回日本皮膚科学会西部支部学術大会
    • Place of Presentation
      長崎ブリックホール(長崎)
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] Langerhans cells migrate to lymph nodes with increased number in mice with Stat3 activation in epidermal keratinocytes and are essential for development of psoriasis-like lesions2015

    • Author(s)
      Kimiko Nakajima, Sayo Kataoka, Mayuko Yamamoto, Bernard Malissen, Shigetoshi Sano
    • Organizer
      45th Annual ESDR Meeting
    • Place of Presentation
      The Beurs-World Trade Center (The Netherlands)
    • Year and Date
      2015-09-09
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乾癬様病変成立に関わるLangerhans細胞の役割2015

    • Author(s)
      中島喜美子、片岡佐誉、山本真有子、Bernard Malissen、佐野栄紀
    • Organizer
      第30回日本乾癬学会学術大会
    • Place of Presentation
      ウェスティンナゴヤキャッスル(名古屋)
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
  • [Presentation] A peculiar reticulated eruption: adverse skin reaction following antifolate drugs2015

    • Author(s)
      Mayuko Yamamoto, Kimiko Nakajima, Shigetoshi Sano
    • Organizer
      23rd World Congress of Dermatology
    • Place of Presentation
      Vancouver Convention Centre(Vancouver)
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Psoriatic inflammation facilitates the onset of arthritis in a mouse model2014

    • Author(s)
      Mayuko Yamamoto, Kimiko Nakajima,Mikiro Takaishi,Shun Kitaba,Yasuhiro Magata,Sayo Kataoka,Shigetoshi Sano
    • Organizer
      The 39th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Hotel Hankyu Expo Park Osaka
    • Year and Date
      2014-12-12 – 2014-12-14
    • Related Report
      2014 Research-status Report
  • [Presentation] MDSおよび再発性多発軟骨炎、肺病変を伴ったSweet症候群の1例2014

    • Author(s)
      山本真有子、志賀建夫、中島英貴、佐野栄紀、近江訓子、鉄谷真由
    • Organizer
      第113回日本皮膚科学会総会
    • Place of Presentation
      京都国際会議場(京都市)
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Langerhans細胞組織球症との鑑別を要した若年性黄色肉芽腫2014

    • Author(s)
      山本真有子、中島喜美子、佐野栄紀、桐生美麿、近添ゆり
    • Organizer
      長崎大学医学部皮膚科学教室開講100周年記念日本皮膚科学会長崎地方会第322回例会
    • Place of Presentation
      長崎大学医学部良順会館(長崎市)
    • Year and Date
      2014-04-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Langerin-expressing cells are dispensable for development of psoriasis-like lesions in a mouse model

    • Author(s)
      中島喜美子
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Research-status Report
  • [Presentation] 乾癬モデルマウスにおけるランゲルハンス細胞の変調

    • Author(s)
      山本真有子
    • Organizer
      第1回ケラチノサイトと免疫を勉強する会
    • Place of Presentation
      丸ビルコンファレンスウスクエア(東京)
    • Related Report
      2013 Research-status Report
  • [Presentation] What is the roles of Langerhans cells in psoriasis ? Are they functional or not?

    • Author(s)
      中島喜美子
    • Organizer
      第27回表皮細胞研究会
    • Place of Presentation
      ホテル談露館(甲府)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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