Malignant melanoma cell kinetics is modulated by adipocyte-cancer cell interaction.

• Project/Area Number: 25461701
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Saga University
• Principal Investigator: Aoki Shigehisa 佐賀大学, 医学部, 准教授 (10448441)
• Co-Investigator(Kenkyū-buntansha): TODA Shuji 佐賀大学, 医学部病因病態科学講座, 教授 (80188755) ; MISAGO Noriyuki 佐賀大学, 医学部皮膚科学講座, 准教授 (90199977)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 皮膚科学 / 悪性黒色腫 / 脂肪細胞 / 脂肪 / 悪性度 / 国際情報交換 / 増殖 / 浸潤

Outline of Final Research Achievements

Malignant melanoma is the most aggressive skin cancer. The effective treatment for advanced cancer patients has not been established. In recent years, the association between obesity and malignant melanoma has been focused in epidemiological studies, but it remains to be elucidated. In the study we used the collagen gel organ culture system utilized with the adipose tissue, and demonstrated that subcutaneous adipose tissue promotes the proliferation of malignant melanoma cells. In addition, the visceral fat tissue may contribute to the invasive ability and melanin production of malignant melanoma cells. According to the present study, adipose tissue was found to contribute deeply to the cell kinetics of malignant melanoma. This organ culture system could be a promising tool for the development and evaluation of new molecular targeted therapies for malignant melanoma.

Research Products

• [Journal Article] A new cell-free bandage-type artificial skin for cutaneous wounds. (2015)
  • Author(s): Aoki S, Takezawa T, Ikeda S, Narisawa Y, Oshikata-Miyazaki A, Miyauchi S, Hirayama H, Sawaguchi T, Chimuro T, Toda S.
  • Journal Title: Wound Repair Regen Volume: 23 Issue: 6 Pages: 819-829
  • DOI: 10.1111/wrr.12321
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro. (2015)
  • Author(s): Aoki S, Noguchi M, Takezawa T, Ikeda S, Uchihashi K, Kuroyama H, Chimuro T, Toda S
  • Journal Title: J Artif Organs Volume: 19 Issue: 1 Pages: 87-96
  • DOI: 10.1007/s10047-015-0864-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Collagen vitrigel membrane: a powerful tool for skin regeneration (2014)
  • Author(s): Shigehisa Aoki, Toshiaki Takezawa, Ayumi Miyazaki-Oshikata, Satoshi Ikeda, Kotaro Nagase, Shinichii Koba, Takuya Inoue, Kazuyoshi Uchihashi, Aki Nishijima-Matsunobu, Nahoko Kakihara, Hiroshi Hirayama, Yutaka Narisawa, Shuji Toda
  • Journal Title: Inflammation and Regeneration Volume: 34 Issue: 3 Pages: 117-123
  • DOI: 10.2492/inflammregen.34.117
  • NAID: 130004943855
  • ISSN: 1880-8190, 1880-9693
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epithelial-to-mesenchymal transition and slit function of mesothelial cells are regulated by the cross talk between mesothelial cells and endothelial cells (2014)
  • Author(s): Aoki S, Takezawa T, Oshikata-Miyazaki A, Ikeda S, Kuroyama H, Chimuro T, Oguchi Y, Noguchi M, Narisawa Y, Toda S.
  • Journal Title: Am J Physiol Renal Physiol. Volume: 1 Issue: 1 Pages: F116-F122
  • DOI: 10.1152/ajprenal.00543.2013
  • Peer Reviewed
• [Remarks] 教員総覧データベース
  • URL: http://evalwww.cc.saga-u.ac.jp/search/IST?ISTActId=FINDJPDetail&ISTKidoKbn=&ISTErrorChkKbn=&ISTFormSetKbn=&ISTTokenChkKbn=&userId=1201