Functional examination of CD147/Basigin as a regulator of tumor cell survival.
Project/Area Number |
25461702
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Kagoshima University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | CD147/Basigin / 皮膚癌 / 治療 / CD147/basigin / EGFR / 悪性黒色腫 / ERシグナル / オートファジー |
Outline of Final Research Achievements |
We examined the function of CD147/Basigin as a regulator of tumor cell survival using a malignant melanoma cell line that expresses high level of CD147/Basigin. CD147/Basigin had no functional relation with ER signaling and autophagy which are the main defense systems against cellular stress. We found that CD147 activates EGFR which plays an important role in the cell proliferation and showed that cell growth was inhibited by the EGFR inhibitor and CD147 silencing, and additive growth inhibition was observed when these ttreatments were combined. These results would yield a improvement of therapeutic outcome in clinical settings.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Genetic analyses of oculocutaneous albinism types 2 and 4 with eight novel mutations.2016
Author(s)
Okamura K, Araki Y, Abe Y, Shigyou A, Fujiyama T, Baba A, Kanekura T, Chinen Y, Kono M, Niizeki H, Tsubota A, Konno T, Hozumi Y, Suzuki T.
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Journal Title
J Dermatol Sci.
Volume: 81
Issue: 2
Pages: 140-2
DOI
Related Report
Peer Reviewed
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[Journal Article] Human T-lymphotropic virus type 1 proviral loads in patients with adult T-cell leukemia-lymphoma: comparison between cutaneous type and other subtypes.2015
Author(s)
Yonekura K, Utsunomiya A, Takatsuka Y, Takeuchi S, Tokunaga M, Kubota A, Takeda K, Kanzaki T, Uchida Y, Kawai K, Kanekura T.
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Journal Title
J Dermatol
Volume: 42
Issue: 12
Pages: 1143-1148
DOI
Related Report
Peer Reviewed
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[Journal Article] Current skin symptoms of Yusho patients exposed to high levels of 2,3,4,7,8-pentachlorinated dibenzofuran and polychlorinated biphenyls in 1968.2015
Author(s)
Mitoma C, Mine Y, Utani A, Imafuku S, Akimoto T, Kanekura T, Furue M, Uchi H.
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Journal Title
Chemosphere
Volume: 137
Pages: 45-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of anti-CCR4 monoclonal antibody (Mogamulizumab) on adult T-cell leukemia-lymphoma (ATL): Cutaneous adverse reactions may predict the prognosis.2014
Author(s)
Yonekura K, Kanzaki T, Gunshin K, Kawkami N, Takatsuka Y, Nakano N, Tokunaga M, Kubota A, Takeuchi S, Kanekura T, Utsunomiya A.
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Journal Title
J Dermatol
Volume: 41
Issue: 3
Pages: 239-244
DOI
Related Report
Peer Reviewed
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[Journal Article] DNA hypermethylation of the forkhead box protein 3 (FOXP3) prompter in CD4+ T cells of patients with systemic sclerosis.2014
Author(s)
Wang YY, Wang Q, Sun XH, Liu RZ, Shu Y, Kanekura T, Huang JH, Li YP, Wang JC, Zhao M, Lu QJ, Xiao R.
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Journal Title
Br J Dermatol
Volume: 171
Issue: 1
Pages: 39-47
DOI
Related Report
Peer Reviewed
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[Journal Article] NKG2D triggers cytotoxicity in murine epidermal γδ T cells via PI3K-dependent, Syk/ZAP70-independent signaling pathway.2014
Author(s)
Ibusuki A, Kawai K, Yoshida S, Uchida Y, Nitahara-Takeuchi A, Kuroki K, Kajikawa M, Ose T, Maenaka K, Kasahara M, Kanekura T.
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Journal Title
J Invest Dermatol
Volume: 134
Issue: 2
Pages: 396-404
DOI
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Peer Reviewed
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[Journal Article] Aberrant histone modification in peripheral blood B cells from patients with systemic sclerosis.2013
Author(s)
Wang Y, Yang Y, Luo Y, Yin Y, Wang Q, Li Y, Kanekura T, Wang J, Liang G, Zhao M,Lu Q, Xiao R.
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Journal Title
Clin Immunol.
Volume: 149
Issue: 1
Pages: 46-54
DOI
Related Report
Peer Reviewed
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