| Project/Area Number |
25461706
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
AIHARA Michiko 横浜市立大学, 医学(系)研究科(研究院), 教授 (90231753)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
GOSHIMA Yoshio 横浜市立大学, 医学(系)研究科(研究院), 教授 (00153750)
IZUHARA Kenji 佐賀大学, 医学部, 教授 (00270463)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | アトピー性皮膚炎 / かゆみ / コラーゲントリペプチド / セマフォリン3A / ペリオスチン |
|---|
| Outline of Final Research Achievements |
Atopic dermatitis is a highly pruritic disease. We assessed effects of collagen tripeptide (CTP);a highly purified, non-antigenic, low allergenic collagen fraction. Because CTP had been shown to have some effects on nerve growth factor (NGF) and semaphorin-3A (Sema3A) to suppress C-fiber extension in mice skin. In the results, CTP suppressed production of TARC, MDS, TSLP in keratinocytes cultured with inflammatory and Th2 cytokines. In AD patients, CTP-administration for 3 months suppressed pruritus. In conclusion, CTP administration may useful for AD treatment, especially to control pruritus.
Periostin (PO) plays an important role in AD. We assessed effects of PO on the cultured cells. In the results, PO suppressed Sema3A production and promoted NGF production in the fibroblast and increased IL-18 and TNF-αproduction in peripheral mononuclear cells. PO may affect pruritus and immune cells in AD patients.
|
