Molecular mechanisms of AhR for environmental factors related to skin aging and diseases

• Project/Area Number: 25461707
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nagoya City University
• Principal Investigator: Morita Akimichi 名古屋市立大学, 医学(系)研究科(研究院), 教授 (30264732)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: AhR / 皮膚老化 / 環境因子 / 紫外線 / 喫煙 / 大気汚染 / 乾癬

Outline of Final Research Achievements

A large scale of molecular epidemiologic study has been conducted for environmental factors (ultraviolet, smoking, air pollution) related to skin aging and skin diseases. A skin aging score was evaluated with SCINEXA and newly developed questionnaires were used. The volunteers including 100 from Nagoya city and 100 from rural city were enrolled. SNPs were analyzed in Leibniz Research Institute for Environmental Medicine in Dusseldorf university. Tabocco smoke extract induced Th17 cells through aryl hydrocarbon receptor (AhR) pathway and induced MITF in melanocytes. Additionally, psoriasis, which is related to environmental factors, was also analyzed for SNPs.

Research Products

• [Int'l Joint Research] IUF, Dusseldorf university(Germany)
• [Journal Article] Environment-induced lentigines: formation of solar lentigines beyond ultraviolet radiation (2015)
  • Author(s): Motoki Nakamura, Akimichi Morita, Sophie Seité, Thomas Haarmann-Stemmann, Susanne Grether-Beck and Jean Krutmann
  • Journal Title: Exp Dermatol Volume: - Issue: 6 Pages: 407-411
  • DOI: 10.1111/exd.12690
  • Peer Reviewed
• [Journal Article] Action spectrum of melanoblast maturation and involvement of the aryl hydrocarbon receptor (2015)
  • Author(s): Motoki Nakamura*, Emi Nishida, Akimichi Morita
  • Journal Title: Exp Dermatol Volume: in press
  • Peer Reviewed
• [Journal Article] Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression. (2013)
  • Author(s): Ono Y, Torii K、Shintani Y, Nishida E, Nakamura M, Shirakata Y, Haarmann-Stemmann T, Abel J, Krutmann J, and Morita A.
  • Journal Title: Exp Dermatol Volume: 22 Issue: 5 Pages: 349-353
  • DOI: 10.1111/exd.12148
  • Peer Reviewed
• [Journal Article] Tobacco smoke-induced skin pigmentationis mediated by the aryl hydrocarbon receptor (2013)
  • Author(s): Motoki Nakamura, Yukiko Ueda, Mai Hayashi, Hiroshi Kato, Takuya Furuhashi, Akimichi Morita
  • Journal Title: Exp Dematol Volume: 22 Issue: 8 Pages: 556-558
  • DOI: 10.1111/exd.12170
  • Peer Reviewed
• [Presentation] Specific genotypes of single nucleotide polymorphisms in Japanese psoriasis patients (2016)
  • Author(s): Kan Torii, Akimichi Morita
  • Organizer: 2016 SID annual meeting
  • Place of Presentation: Scottsdale,USA
  • Year and Date: 2016-05-11
• [Presentation] Daily photoprotecion in the prevention of skin aging among Asians (2015)
  • Author(s): Akimichi Morita
  • Organizer: 3nd World Congress of Dermatology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2015-06-08
  • Int'l Joint Research / Invited
• [Presentation] Phenotyping of extrinsic skin aging reveals age- and site-dependent differences between German, Chinese and Japanese women, (2015)
  • Author(s): Andrea Vierkotter, Tamara Schikowski, Mohammad Vossoughi, Sabine Stolz, Anke Huls, Mary Matsui, Ai Yamamoto, Li Jin, Akimichi Morita, Sijia Wang, Zhiwen Li, Jean Krutmann
  • Organizer: 2015 SID annual meeting
  • Place of Presentation: Atlanta, USA
  • Year and Date: 2015-05-06
  • Int'l Joint Research
• [Presentation] Skin againg and environmental factors (2014)
  • Author(s): Akimichi Morita
  • Organizer: 20th Korean Society for Skin Barrier Research Annual Symposium
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2014-09-30
  • Invited
• [Presentation] Skin aging evaluation based on our experience in Japan (2014)
  • Author(s): Akimichi Morita
  • Organizer: Round Table Discussion of Chinese Skin Aging Evaluation
  • Place of Presentation: Beijing, China
  • Year and Date: 2014-09-27 – 2014-09-28
  • Invited
• [Presentation] Tobocco smoking and skin againg (2014)
  • Author(s): Akimichi Morita
  • Organizer: 11th International Congress of Cosmetic Dermatology (photoaging)
  • Place of Presentation: Beijing,China
  • Year and Date: 2014-09-26 – 2014-09-28
  • Invited
• [Presentation] Skin Cancer Risks following Long-Term Phototherapy in Dark-Skinned Patients (2014)
  • Author(s): Akimichi Morita
  • Organizer: 3rd Eastern Asia Dermatology Congress
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2014-09-24 – 2014-09-26
  • Invited
• [Presentation] Tobacco smoke enhances skin againg mediating through aryl hydrocarbon receptor (2014)
  • Author(s): Akimichi Morita
  • Organizer: Cutaneous Biology 2014 (Australasian Society of Dermatology Research)
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2014-09-22 – 2014-09-26
• [Presentation] Action spectrum of melanoblast activation for vitiligo-dedicated UV therapy (2014)
  • Author(s): Motoki Nakamura, Kan Torii, Shinosuke Muramatsu, Ryoji Kubo, Emi Nishida, Akimichi Morita
  • Organizer: European Society of Investigative Dermatilogy 2014
  • Place of Presentation: Kopenhagen,Denmark
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Characterization Of Actinic Lentigines In Japanese Population: From Clinical Analysis To Gene Expression Profiling (2014)
  • Author(s): Christine Duval, Emilie Warrick, Stéphanie Nouveau, Claire Marie Benoit-Jay, Philippe Bastien, Sophie Deret, Akimichi Morita, Olivier de Lacharrière, Françoise Bernerd
  • Organizer: The XXII international pigment cell conference (IPCC)
  • Place of Presentation: Shangri-La Hotel,Singapore
  • Year and Date: 2014-09-04 – 2014-09-07
• [Presentation] Environmental factor and pigmentation (2014)
  • Author(s): Akimichi Morita
  • Organizer: The XXII international pigment cell conference (IPCC)
  • Place of Presentation: Shangri-La Hotel,Singapore
  • Year and Date: 2014-09-04 – 2014-09-07
  • Invited
• [Presentation] Action spectrum of melanoblast activation for vitiligo-dedicated UV therapy (2014)
  • Author(s): Motoki Nakamura, Kan Torii, Takuya Furuhashi, Emi Nishida, Akimichi Morita
  • Organizer: German-Japanese Dermatology Society
  • Place of Presentation: Heidelberg,Germany
  • Year and Date: 2014-06-11 – 2014-06-14
• [Presentation] UVB wavelength dependency of HMGB1 production by human keratinocytes (2014)
  • Author(s): Kan Torii, Motoki Nakamura, Takuya Furuhashi, Emi Nishida, Akimichi Morita
  • Organizer: 2014SID annual meeting
  • Place of Presentation: Albuquerque,America
  • Year and Date: 2014-05-07 – 2014-05-10
• [Presentation] Circulating central memory T cells are negatively correlated with lesional Foxp3+ regulatory T cells in psoriasis patients (2014)
  • Author(s): Emi Nishida, Saori Kasuya, Akiko Nishioka, Takuya Furuhashi, Akimichi Morita
  • Organizer: 2014 SID annual meeting
  • Place of Presentation: Albuquerque,America
  • Year and Date: 2014-05-07 – 2014-05-10
• [Presentation] Environmental factor and pigmentation (2014)
  • Author(s): Akimichi Morita
  • Organizer: The XXII international pigment cell conference (IPCC)
  • Place of Presentation: Shangri-La Hotel（Singapore,Singapore）
  • Invited
• [Presentation] Tobacco smoke-induced skin pigmentation is mediated by the Wnt/b-catenin pathway and the aryl hydrocarbon receptor signaling. (2013)
  • Author(s): Motoki Nakamura, Yukiko Ueda, Takuya Furuhashi, Akimichi Morita
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh International Conference Centre(Edinburgh UK)
• [Presentation] Skin and Environment (2013)
  • Author(s): Akimichi Morita
  • Organizer: Munich International Summer Academy of Practical dermatology (ISA2013)
  • Place of Presentation: Holiday Inn（Munich,Germany）
  • Invited
• [Presentation] Tobocco smoking and skin againg (2013)
  • Author(s): Akimichi Morita
  • Organizer: XIthInternational Congress of Dermatology - 2013
  • Place of Presentation: Hotel The Ashok（New Deli, India）
  • Invited