The establishment of new treatment by cannabinoid receptor signaling on intractable alopecias

• Project/Area Number: 25461708
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Osaka City University
• Principal Investigator: Sugawara Koji 大阪市立大学, 大学院医学(系)研究科(研究院), 講師 (50634078)
• Co-Investigator(Kenkyū-buntansha): Tsuruta Daisuke 大阪市立大学, 大学院医学研究科, 教授 (90382043)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: カンナビノイド受容体 / 毛包幹細胞 / 瘢痕性脱毛症 / カンナビノイド受容体タイプ1 / 瘢痕性脱毛 / 脱毛症

Outline of Final Research Achievements

Our results show that cannabinoid receptor type 1 (CB1) signaling can control human hair follicle stem cell proliferation/apoptosis. CB1 could be a new target for treating intractable alopecia including scarring alopecia.

Research Products

• [Presentation] Cannabinoid receptor (CB) 1 signaling regulates laminin-511 expression of human hair follicle (2015)
  • Author(s): Aki Natsumi, Koji Sugawara, Makiko Yasumizu, Ralf Paus, Daisuke Tsuruta
  • Organizer: 9th World Congress for Hair Research
  • Place of Presentation: マイアミ（アメリカ合衆国）
  • Year and Date: 2015-11-18
  • Int'l Joint Research
• [Presentation] 皮膚疾患における カンナビノイド受容体の役割について (2014)
  • Author(s): 菅原 弘二
  • Organizer: 第1回関西若手皮膚科医の集い
  • Place of Presentation: 大阪大学医学部（大阪府・吹田市）
  • Year and Date: 2014-11-01
• [Presentation] カンナビノイドは皮膚疾患を救うか？ (2014)
  • Author(s): 菅原 弘二
  • Organizer: 第46回日本臨床分子形態学会総会・学術集会
  • Place of Presentation: TKP市ヶ谷カンファレンスセンター（東京都・新宿区市谷八幡町）
  • Year and Date: 2014-10-17
  • Invited
• [Presentation] Cannabinoid receptor (CB)1 regulates laminin-511 expression in human skin (2014)
  • Author(s): Koji Sugawara
  • Organizer: 44TH Annual ESDR Meeting
  • Place of Presentation: Copenhagen (Denmark)
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] カンナビノイド受容体タイプ1シグナルは ヒト毛包幹細胞の増殖能をコントロールする (2014)
  • Author(s): 菅原 弘二
  • Organizer: 第33回分子病理学研究会
  • Place of Presentation: 宮城蔵王ロイヤルホテル（宮城県・刈田郡蔵王町）
  • Year and Date: 2014-07-25
• [Presentation] ヒト毛包幹細胞および前駆細胞の増殖能はカンナビノイド受容体タイプ1シグナルにより促進する (2014)
  • Author(s): 菅原 弘二
  • Organizer: 第442回大阪地方会
  • Place of Presentation: 朝日生命ホール、大阪
• [Presentation] “Tonic” cannabinoid receptor 1 signaling regulates human hair follicle epithelial progenitor cell survival in situ (2013)
  • Author(s): Koji Sugawara
  • Organizer: International Investigative Dermatology 2013
  • Place of Presentation: Edinburgh International Conference Centre, Edinburgh, Scotland
• [Presentation] Continuously”stoned” epithelial stem cells: Dependence of human hair follicle epithelial progenitor cells in situ on “tonic” cannabinoid receptor 1-stimulation (2013)
  • Author(s): Koji Sugawara
  • Organizer: Gordon Research Conference
  • Place of Presentation: Renaissance Tuscany Il Ciocco Resort, Lucca, Italy