Roles of protease allergen in epicutaneous sensitization
Project/Area Number |
25461711
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | Juntendo University |
Principal Investigator |
Takai Toshiro 順天堂大学, 医学(系)研究科(研究院), 准教授 (70338375)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 経皮感作 / プロテアーゼアレルゲン / アレルギーマーチ / IgE/Th2/Th17 / 皮膚炎症 / バリア破壊 / 模擬引っ掻きモデル / 洗剤モデル / マウスモデル / アトピー性皮膚炎 |
Outline of Final Research Achievements |
Epicutaneous sensitization has been considered as an important route for sensitization to allergens not only in atopic dermatitis but also towards other allergic diseases such as asthma (atopic march). Allergen sources such as mites and pollen produce or contain proteases, which can stimulate various types of cells. In this study, we established a murine model of epicutaneous sensitization to protease allergen and demonstrated that the protease activity of epicutaneously administered antigen markedly promoted sensitization and skin inflammation towards development of atopic march in airway.
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Report
(5 results)
Research Products
(63 results)
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[Journal Article] Skin treatment with detergent promotes protease allergen-dependent epicutaneous sensitization in a manner different from tape stripping in mice2017
Author(s)
Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S
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Journal Title
J Invest Dermatol
Volume: 掲載確定
Issue: 7
Pages: 1578-1582
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Epicutaneous allergic sensitization by cooperation between allergn protease activity and mechanical skin barrier damage in mice2016
Author(s)
Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.
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Journal Title
J Invest Dermatol
Volume: 136
Issue: 7
Pages: 1408-1417
DOI
Related Report
Peer Reviewed
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[Journal Article] Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes2016
Author(s)
Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T.
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Journal Title
J Immunol
Volume: 196
Issue: 9
Pages: 3559-3569
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice2016
Author(s)
Suzuki M, Hara M, Ichikawa S, Kamijo S, Nakazawa T, Hatanaka H, Akiyama K, Ogawa H, Okumura K, Takai T
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Journal Title
Allergology International
Volume: 65
Issue: 1
Pages: 44-51
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pectate lyase pollen allergens: Sensitization profiles and cross-reactivity pattern2015
Author(s)
Pichler U, Hauser M, Wolf M, Bernardi ML, Gadermaier G, Weiss R, Ebner C, Yokoi H, Takai T, Didierlaurent A, Rafaiani C, Briza P, Mari A, Behrendt H, Wallner M, Ferreira F
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Journal Title
PLoS One
Volume: 10
Issue: 5
Pages: e0120038-e0120038
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner2014
Author(s)
Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S
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Journal Title
Allergology International
Volume: 63
Issue: 2
Pages: 219-226
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] TSLP expression induced via Toll-like receptor pathways in human keratinocytes2014
Author(s)
Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K
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Journal Title
Methods Enzymol
Volume: 535
Pages: 371-387
DOI
Related Report
Peer Reviewed
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[Journal Article] Immunization of Rabbits with Nematode <i>Ascaris lumbricoides</i> Antigens Induces Antibodies Cross-Reactive to House Dust Mite <i>Dermatophagoides farinae</i> Antigens2013
Author(s)
Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K.
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Journal Title
Bioscience, Biotechnology, and Biochemistry
Volume: 77
Issue: 1
Pages: 145-150
DOI
NAID
ISSN
0916-8451, 1347-6947
Related Report
Peer Reviewed
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[Presentation] Protease allergen and tape-stripping cooperatively promote epidermal barrier dysfunction and proinflammatory gene expression in mice2016
Author(s)
Suchiva P, Takai T, Maruyama N, Iida H, Shimura S, Ochi H, Kamijo S, Nishioka I, Okumura K, Ikeda S, Ogawa H
Organizer
日本研究皮膚科学会
Place of Presentation
仙台, 宮城
Year and Date
2016-12-09
Related Report
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[Presentation] Epicutaneous administration of protease allergen and mechanical skin barrier damage synergistically promote epidermal barrier dysfunction and proinflammatory gene expression toward allergic sensitization in mice2016
Author(s)
Suchiva P, Takai T, Maruyama N, Iida H, Shimura S, Ochi H, Kamijo S, Nishioka I, Okumura K, Ikeda S, Ogawa H
Organizer
The 4th Eastern Asia Dermatology Congress
Place of Presentation
浦安, 千葉
Year and Date
2016-11-16
Related Report
Int'l Joint Research
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[Presentation] Epicutaneous allergic sensitization by synergy between allergen protease-activity and mechanical skin barrier damage in mice2016
Author(s)
Takai T, Iida H, Shimura S, Ochi H, Maruyama N, Nishioka I, Kamijo S, Hara M, Saito H, Nakae S, Ogawa H, Ikeda S, Okumura K
Organizer
31th Symposium of the Collegium Internationale Allergologicum
Place of Presentation
Charleston, SC, USA
Year and Date
2016-04-03
Related Report
Int'l Joint Research
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[Presentation] Murine models of epicutaneous sensitization to protease allergen, which leads to allergic airway inflammation upon subsequent airway challenge2015
Author(s)
Shimura S, Takai T, Iida H, Kamijo S, Ochi H, Maruyama N, Nishioka I, Suchiva P, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S
Organizer
日本研究皮膚科学会
Place of Presentation
岡山コンベンションセンター(岡山県岡山市)
Year and Date
2015-12-11
Related Report
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[Presentation] Subcutaneous presentitization to protease antigen and IL-33-dependent airway responses cooperatively contribute to airway inflammation2015
Author(s)
Ochi H, Takai T, Kamijo S, Shimura S, Maruyama N, Matsuda A, Saito H, Nakae S, Okumura K, Ogawa H, Ikeda
Organizer
日本研究皮膚科学会
Place of Presentation
岡山コンベンションセンター(岡山県岡山市)
Year and Date
2015-12-11
Related Report
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[Presentation] The role of protease allergens in the establishment of epicutaneous sensitization2014
Author(s)
Sakiko Shimura, Toshiro Takai, Hideo Iida, Yusuke Hirasawa, Seiji Kamijo, Hirono Ochi, Izumi Nishioka, Natsuko Maruyama, Mutsuko Hara, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda
Organizer
日本研究皮膚科学会第39回年次学術大会・総会
Place of Presentation
阪急エキスポパーク、大阪
Year and Date
2014-12-12 – 2014-12-14
Related Report
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