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Roles of protease allergen in epicutaneous sensitization

Research Project

Project/Area Number 25461711
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Dermatology
Research InstitutionJuntendo University

Principal Investigator

Takai Toshiro  順天堂大学, 医学(系)研究科(研究院), 准教授 (70338375)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords経皮感作 / プロテアーゼアレルゲン / アレルギーマーチ / IgE/Th2/Th17 / 皮膚炎症 / バリア破壊 / 模擬引っ掻きモデル / 洗剤モデル / マウスモデル / アトピー性皮膚炎
Outline of Final Research Achievements

Epicutaneous sensitization has been considered as an important route for sensitization to allergens not only in atopic dermatitis but also towards other allergic diseases such as asthma (atopic march). Allergen sources such as mites and pollen produce or contain proteases, which can stimulate various types of cells. In this study, we established a murine model of epicutaneous sensitization to protease allergen and demonstrated that the protease activity of epicutaneously administered antigen markedly promoted sensitization and skin inflammation towards development of atopic march in airway.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (63 results)

All 2017 2016 2015 2014 2013 Other

All Journal Article (25 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Acknowledgement Compliant: 3 results,  Open Access: 7 results) Presentation (37 results) (of which Int'l Joint Research: 3 results,  Invited: 11 results) Remarks (1 results)

  • [Journal Article] Skin treatment with detergent promotes protease allergen-dependent epicutaneous sensitization in a manner different from tape stripping in mice2017

    • Author(s)
      Ochi H, Takai T, Shimura S, Maruyama N, Nishioka I, Kamijo S, Iida H, Nakae S, Ogawa H, Okumura K, Ikeda S
    • Journal Title

      J Invest Dermatol

      Volume: 掲載確定 Issue: 7 Pages: 1578-1582

    • DOI

      10.1016/j.jid.2017.02.970

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Epicutaneous allergic sensitization by cooperation between allergn protease activity and mechanical skin barrier damage in mice2016

    • Author(s)
      Shimura S, Takai T, Iida H, Maruyama N, Ochi H, Kamijo S, Nishioka I, Hara M, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S.
    • Journal Title

      J Invest Dermatol

      Volume: 136 Issue: 7 Pages: 1408-1417

    • DOI

      10.1016/j.jid.2016.02.810

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subcutaneous Allergic Sensitization to Protease Allergen Is Dependent on Mast Cells but Not IL-33: Distinct Mechanisms between Subcutaneous and Intranasal Routes2016

    • Author(s)
      Kamijo S, Suzuki M, Hara M, Shimura S, Ochi H, Maruyama N, Matsuda A, Saito H, Nakae S, Suto H, Ichikawa S, Ikeda S, Ogawa H, Okumura K, Takai T.
    • Journal Title

      J Immunol

      Volume: 196 Issue: 9 Pages: 3559-3569

    • DOI

      10.4049/jimmunol.1500717

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Innate basophil IL-4 responses against allergens, endotoxin, and cytokines require the Fc receptor γ-chain.2016

    • Author(s)
      Kamijo S, Nunomura S, Ra C, Kanaguchi Y, Suzuki Y, Ogawa H, Okumura K, Takai T.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 137 Issue: 5 Pages: 1613-1615

    • DOI

      10.1016/j.jaci.2015.10.037

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] 専門医のためのアレルギー講座:アレルゲンとその修飾因子2016

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー(日本アレルギー学会誌)

      Volume: 65 Pages: 159-165

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 環境アレルゲン2016

    • Author(s)
      高井敏朗
    • Journal Title

      日本医師会雑誌特別号「アレルギー疾患の全て

      Volume: 145

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 好塩基球の自然免疫応答によるIL-4産生のFc受容体γ鎖依存性2016

    • Author(s)
      高井敏朗, 上條清嗣, 布村聡, 羅智靖, 小川秀興, 奧村康
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 66 Pages: 371-374

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 家塵ダニアレルゲンの性状と標準化2016

    • Author(s)
      高井敏朗
    • Journal Title

      喘息・アレルギー

      Volume: 29 Pages: 15-19

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Presensitization to Ascaris antigens promotes induction of mite-specific IgE upon mite antigen inhalation in mice2016

    • Author(s)
      Suzuki M, Hara M, Ichikawa S, Kamijo S, Nakazawa T, Hatanaka H, Akiyama K, Ogawa H, Okumura K, Takai T
    • Journal Title

      Allergology International

      Volume: 65 Issue: 1 Pages: 44-51

    • DOI

      10.1016/j.alit.2015.07.003

    • NAID

      130005290333

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunotherapy to treat allergies: Recent advances and future prospects2015

    • Author(s)
      Takai T
    • Journal Title

      Juntendo Medical Journal

      Volume: 61 Pages: 597-560

    • NAID

      130005133289

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Allergens in modern society: Updated catalogs and future prospects2015

    • Author(s)
      Takai T, Izuhara K
    • Journal Title

      Allergology International

      Volume: 64 Issue: 4 Pages: 293-294

    • DOI

      10.1016/j.alit.2015.08.003

    • NAID

      130005290405

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report
    • Open Access
  • [Journal Article] Pectate lyase pollen allergens: Sensitization profiles and cross-reactivity pattern2015

    • Author(s)
      Pichler U, Hauser M, Wolf M, Bernardi ML, Gadermaier G, Weiss R, Ebner C, Yokoi H, Takai T, Didierlaurent A, Rafaiani C, Briza P, Mari A, Behrendt H, Wallner M, Ferreira F
    • Journal Title

      PLoS One

      Volume: 10 Issue: 5 Pages: e0120038-e0120038

    • DOI

      10.1371/journal.pone.0120038

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines - Secondary publication2015

    • Author(s)
      Takai T, Okamoto Y, Okubo K, Nagata M, Sakaguchi M, Fukutomi Y, Saito A, Yasueda H, Masuyama K
    • Journal Title

      Allergology International

      Volume: 64 Issue: 2 Pages: 181-186

    • DOI

      10.1016/j.alit.2015.01.005

    • NAID

      130005290283

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cysteine protease antigens cleave CD123, the α subunit of murine IL-3 receptor, on basophils and suppress IL-3-mediated basophil expansion2015

    • Author(s)
      Nishikado H, Fujimura T, Taka H, Mineki R, Ogawa H, Okumura K, Takai T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 印刷中 Issue: 2 Pages: 261-266

    • DOI

      10.1016/j.bbrc.2015.03.022

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-33とアレルゲン2015

    • Author(s)
      高井敏朗
    • Journal Title

      医学のあゆみ

      Volume: 252 Pages: 1226-1232

    • Related Report
      2014 Research-status Report
  • [Journal Article] Epicutaneous Administration of Papain Induces IgE and IgG Responses in a Cysteine Protease Activity-Dependent Manner2014

    • Author(s)
      Iida H, Takai T, Hirasawa Y, Kamijo S, Shimura S, Ochi H, Nishioka I, Maruyama N, Ogawa H, Okumura K, Ikeda S
    • Journal Title

      Allergology International

      Volume: 63 Issue: 2 Pages: 219-226

    • DOI

      10.2332/allergolint.13-OA-0621

    • NAID

      130004477213

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2014 Research-status Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Repeated antigen painting and sublingual immunotherapy in mice convert sublingual dendritic cell subsets2014

    • Author(s)
      Zhang C, Ohno T, Kang S, Takai T, Azuma M
    • Journal Title

      Vaccine

      Volume: 32 Issue: 43 Pages: 5669-5676

    • DOI

      10.1016/j.vaccine.2014.08.013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] ダニアレルゲンワクチン標準化に関する日本アレルギー学会タスクフォース報告2014

    • Author(s)
      46.高井敏朗, 岡本美孝, 大久保公裕, 永田真, 阪口雅弘, 福冨友馬, 齋藤明美, 安枝浩, 増山敬祐
    • Journal Title

      アレルギー

      Volume: 63 Pages: 1229-1240

    • NAID

      110009865616

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 環境アレルゲン解析の進歩2014

    • Author(s)
      高井敏朗
    • Journal Title

      小児科診療

      Volume: 77 Pages: 1241-1247

    • Related Report
      2014 Research-status Report
  • [Journal Article] TSLP expression induced via Toll-like receptor pathways in human keratinocytes2014

    • Author(s)
      Takai T, Chen X, Xie Y, Vu AT, Le TA, Kinoshita H, Kawasaki J, Kamijo S, Hara M, Ushio H, Baba T, Hiramatsu K, Ikeda S, Ogawa H, Okumura K
    • Journal Title

      Methods Enzymol

      Volume: 535 Pages: 371-387

    • DOI

      10.1016/b978-0-12-397925-4.00021-3

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-33-mediated innate response and adaptive immune cells contribute to maximum responses of protease allergen-induced allergic airway inflammation2013

    • Author(s)
      Seiji Kamijo
    • Journal Title

      J Immunol

      Volume: 190 Issue: 9 Pages: 4489-4499

    • DOI

      10.4049/jimmunol.1201212

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human antimicrobial peptide LL-37 modulates proinflammatory responses induced by cytokine milieus and double-stranded RNA in human keratinocytes2013

    • Author(s)
      Xue Chen
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 433 Issue: 4 Pages: 532-537

    • DOI

      10.1016/j.bbrc.2013.03.024

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunization of Rabbits with Nematode <i>Ascaris lumbricoides</i> Antigens Induces Antibodies Cross-Reactive to House Dust Mite <i>Dermatophagoides farinae</i> Antigens2013

    • Author(s)
      Nakazawa T, Khan AF, Yasueda H, Saito A, Fukutomi Y, Takai T, Zaman K, Yunus M, Takeuchi H, Iwata T, Akiyama K.
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 77 Issue: 1 Pages: 145-150

    • DOI

      10.1271/bbb.120626

    • NAID

      10031164704

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] アレルゲンはなぜアレルゲンになるのか?:アレルゲンが引き起こすバリア破壊と自然免疫応答2013

    • Author(s)
      高井敏朗
    • Journal Title

      実験医学

      Volume: 31 Pages: 2713-2719

    • Related Report
      2013 Research-status Report
  • [Journal Article] ダニアレルゲンによる経皮感作のメカニズム2013

    • Author(s)
      高井敏朗
    • Journal Title

      アレルギー・免疫

      Volume: 20 Pages: 854-860

    • Related Report
      2013 Research-status Report
  • [Presentation] Protease allergen and tape-stripping cooperatively promote epidermal barrier dysfunction and proinflammatory gene expression in mice2016

    • Author(s)
      Suchiva P, Takai T, Maruyama N, Iida H, Shimura S, Ochi H, Kamijo S, Nishioka I, Okumura K, Ikeda S, Ogawa H
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      仙台, 宮城
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
  • [Presentation] Skin IL-17A production from activated dendritic epidermal T cells contributes to enhancement of papaininduced allergic responses in the skin2016

    • Author(s)
      Kamijo S, Nakae S, Ogawa H, Okumura K, Takai T
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Epicutaneous administration of protease allergen and mechanical skin barrier damage synergistically promote epidermal barrier dysfunction and proinflammatory gene expression toward allergic sensitization in mice2016

    • Author(s)
      Suchiva P, Takai T, Maruyama N, Iida H, Shimura S, Ochi H, Kamijo S, Nishioka I, Okumura K, Ikeda S, Ogawa H
    • Organizer
      The 4th Eastern Asia Dermatology Congress
    • Place of Presentation
      浦安, 千葉
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プロテアーゼアレルゲン皮下感作はIL-33非依存的・マスト細胞依存的に誘導される2016

    • Author(s)
      7. 清村咲子、高井敏朗、上條清嗣、鈴木麻友、原むつ子、越智啓乃、丸山奈津子、松田彰、齋藤博久、中江進、市川さおり、小川秀興、 奥村康、池田志斈
    • Organizer
      日本接触性皮膚炎・皮膚アレルギー学会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2016-11-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Allergens as adjuvants: barrier disruption and innate immunity2016

    • Author(s)
      Takai T
    • Organizer
      East Asia Allergy Symposium
    • Place of Presentation
      Nanjing, China
    • Year and Date
      2016-09-02
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] プロテアーゼ活性を有する抗原による経皮感作とアレルギー疾患2016

    • Author(s)
      高井敏朗
    • Organizer
      第21回日本病態プロテアーゼ学会学術集会
    • Place of Presentation
      千里ライフサイエンスセンター, 大阪
    • Year and Date
      2016-08-05
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ダニアレルゲンワクチン標準化に関する日本アレルギー学会タスクフォース報告2016

    • Author(s)
      12. 高井敏朗, 岡本美孝, 大久保公裕, 永田真, 阪口雅弘, 福冨友馬, 齋藤明美, 安枝浩, 増山敬祐
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2016-06-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] アレルゲン、LPSおよびサイトカイン刺激による好塩基球のIL-4 産生はFc受容体g鎖に依存する2016

    • Author(s)
      上條清嗣, 布村聡, 羅 智靖, 金口泰彦, 鈴木祐介, 小川秀興, 奥村康, 高井敏朗
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
  • [Presentation] Epicutaneous allergic sensitization by synergy between allergen protease-activity and mechanical skin barrier damage in mice2016

    • Author(s)
      Takai T, Iida H, Shimura S, Ochi H, Maruyama N, Nishioka I, Kamijo S, Hara M, Saito H, Nakae S, Ogawa H, Ikeda S, Okumura K
    • Organizer
      31th Symposium of the Collegium Internationale Allergologicum
    • Place of Presentation
      Charleston, SC, USA
    • Year and Date
      2016-04-03
    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Murine models of epicutaneous sensitization to protease allergen, which leads to allergic airway inflammation upon subsequent airway challenge2015

    • Author(s)
      Shimura S, Takai T, Iida H, Kamijo S, Ochi H, Maruyama N, Nishioka I, Suchiva P, Matsuda A, Saito H, Nakae S, Ogawa H, Okumura K, Ikeda S
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Subcutaneous presentitization to protease antigen and IL-33-dependent airway responses cooperatively contribute to airway inflammation2015

    • Author(s)
      Ochi H, Takai T, Kamijo S, Shimura S, Maruyama N, Matsuda A, Saito H, Nakae S, Okumura K, Ogawa H, Ikeda
    • Organizer
      日本研究皮膚科学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] プロテアーゼアレルゲンの経皮的投与による皮膚バリア機能障害および抗体産生誘導の検討2015

    • Author(s)
      越智啓乃、高井敏朗、飯田秀雄、上條清嗣、清村咲子、西岡いずみ、丸山奈津子、奥村康、小川秀興、池田志斈
    • Organizer
      日本皮膚アレルギー・接触性皮膚炎学会
    • Place of Presentation
      島根県民会館(島根県松江市)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Presentation] Subcutaneous allergic sensitization to protease allergen is dependent on mast cells but not IL-33: Distinct mechanisms between subcutaneous and intranasal routes2015

    • Author(s)
      Kamijo S, Takai T, Hara M, Matsuda H, Matsuda A, Saito H, Nakae S, Ichikawa S, Ogawa H, Okumura K
    • Organizer
      日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Epicutaneous allergic sensitization by synergy between allergen protease-activity and mechanical skin barrier damage in mice2015

    • Author(s)
      Takai T, Nishioka I, Iida H, Shimura S, Ochi H, Maruyama N, Okumura K, Ogawa H, Ikeda S
    • Organizer
      表皮細胞研究会
    • Place of Presentation
      ホテルニューオータニ佐賀(佐賀県佐賀市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] アレルゲンの生物活性とアジュバント作用:なぜアレルゲンになるのか2015

    • Author(s)
      高井敏朗
    • Organizer
      日本眼薬理学会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都千代田区)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
  • [Presentation] パパインの経皮感作マウスモデルによるプロテアーゼ活性依存的な特異的抗体産生誘導2015

    • Author(s)
      西岡いずみ、高井敏朗、飯田秀雄、上條清嗣、清村咲子、越智啓乃、丸山奈津子、奥村康、小川秀興、池田志斈
    • Organizer
      日本皮膚科学会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2015-05-29 – 2015-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] パパイン皮下投与感作マウスのアトピーマーチにおけるIL-33の関与2015

    • Author(s)
      越智啓乃、高井敏朗、飯田秀雄、上條清嗣、清村咲子、西岡いずみ、丸山奈津子、奥村康、小川秀興、池田志斈
    • Organizer
      日本皮膚科学会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2015-05-29 – 2015-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] パパインの経皮感作マウスモデルによるプロテアーゼ活性依存的な特異的抗体産生誘導2015

    • Author(s)
      西岡いずみ、高井敏朗、飯田秀雄、上條清嗣、清村咲子、越智啓乃、丸山奈津子、奥村康、小川秀興、池田志斈
    • Organizer
      日本皮膚科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
  • [Presentation] パパイン皮下投与感作マウスのアトピーマーチにおけるIL-33の関与2015

    • Author(s)
      越智啓乃、高井敏朗、飯田秀雄、上條清嗣、清村咲子、西岡いずみ、丸山奈津子、奥村康、小川秀興、池田志斈
    • Organizer
      日本皮膚科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
  • [Presentation] プロテアーゼ抗原塗布とテープストリッピングはIL-33非依存的に皮膚炎症および抗体産生を促進する2015

    • Author(s)
      清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、西岡いづみ、齋藤博久、中江進、小川秀興、池田志斈、奥村康
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      グランドプリンスホテル新高輪、東京
    • Year and Date
      2015-05-26 – 2015-05-28
    • Related Report
      2014 Research-status Report
  • [Presentation] シンポジウム18: アレルギー疾患とマウスモデル. マウスモデルを用いたアレルゲンの生物活性の解析2015

    • Author(s)
      高井敏朗、上條清嗣、小川秀興、池田志斈、奧村康
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      グランドプリンスホテル新高輪、東京
    • Year and Date
      2015-05-26 – 2015-05-28
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] プロテアーゼ抗原塗布とテープストリッピングはIL-33非依存的に皮膚炎症および抗体産生を促進する2015

    • Author(s)
      清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、西岡いづみ、齋藤博久、中江進、小川秀興、池田志斈、奥村康
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
  • [Presentation] シンポジウム18: アレルギー疾患とマウスモデル. マウスモデルを用いたアレルゲンの生物活性の解析2015

    • Author(s)
      高井敏朗、上條清嗣、小川秀興、池田志斈、奧村康
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2015-05-26
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] アレルギー疾患の修飾因子:1. アレルゲンとその修飾因子2015

    • Author(s)
      高井敏朗
    • Organizer
      第2回 総合アレルギー講習会(日本アレルギー学会)
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-04-12
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] アレルゲンが引き起こすバリア破壊と自然免疫応答2015

    • Author(s)
      高井敏朗
    • Organizer
      ABCの会
    • Place of Presentation
      ホテルニューオータニ、東京
    • Year and Date
      2015-01-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] アレルギー疾患の修飾因子 1. アレルゲンとその修飾因子2014

    • Author(s)
      高井敏朗
    • Organizer
      日本アレルギー学会 第1回総合アレルギー講習会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Year and Date
      2014-12-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The role of protease allergens in the establishment of epicutaneous sensitization2014

    • Author(s)
      Sakiko Shimura, Toshiro Takai, Hideo Iida, Yusuke Hirasawa, Seiji Kamijo, Hirono Ochi, Izumi Nishioka, Natsuko Maruyama, Mutsuko Hara, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda
    • Organizer
      日本研究皮膚科学会第39回年次学術大会・総会
    • Place of Presentation
      阪急エキスポパーク、大阪
    • Year and Date
      2014-12-12 – 2014-12-14
    • Related Report
      2014 Research-status Report
  • [Presentation] Subcutaneous presensitization to protease antigen enhances protease-induced allergic airway inflammation2014

    • Author(s)
      Hirono Ochi, Toshiro Takai, Seiji Kamijo, Sakiko Shimura, Natsuko Maruyama, Ko Okumura, Hideoki Ogawa, Shigaku Ikeda
    • Organizer
      日本研究皮膚科学会第39回年次学術大会・総会
    • Place of Presentation
      阪急エキスポパーク、大阪
    • Year and Date
      2014-12-12 – 2014-12-14
    • Related Report
      2014 Research-status Report
  • [Presentation] プロテアーゼアレルゲンの経皮的投与による皮膚バリア機能低下および抗体産生誘導の検討2014

    • Author(s)
      西岡いずみ、高井敏朗 、飯田秀雄、上條清嗣、清村咲子、越智啓乃、丸山奈津子、原むつ子、奥村康 、小川秀興 、池田志斈
    • Organizer
      第44回日本皮膚アレルギー・接触皮膚炎学会総会・学術大会
    • Place of Presentation
      仙台国際センター、宮城
    • Year and Date
      2014-11-21 – 2014-11-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Distinct mechanisms for allergic sensitization to protease antigen between skin and airway2014

    • Author(s)
      Takai T, Kamijo S, Saito H, Nakae S, Ogawa H, Okumura K
    • Organizer
      0th Symposium of the Collegium Internationale Allergologicum (CIA)
    • Place of Presentation
      Petersberg, Germany
    • Year and Date
      2014-09-12 – 2014-09-18
    • Related Report
      2014 Research-status Report
  • [Presentation] プロテアーゼアレルゲンによる経皮的感作はプロテアーゼ活性依存的にIgE/IgG産生を誘導する2014

    • Author(s)
      清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、原むつ子、小川秀興、池田志斈
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      京都国際会館、京都
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
  • [Presentation] シンポジウム3:アレルギーにおける自然免疫応答.プロテアーゼアレルゲンによるIgE産生と気道炎症の誘導2014

    • Author(s)
      上條清嗣、高井敏朗、中江進、齋藤博久、奧村康
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      京都国際会館、京都
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] アレルギー診療に役立つ免疫講座1.アレルゲンが引き起こすバリア破壊と自然免疫応答2014

    • Author(s)
      高井敏朗
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      京都国際会館、京都
    • Year and Date
      2014-05-09 – 2014-05-11
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] IL-33 does not contribute to subcutaneous sensitization to cysteine protease allergen but contributes to allergic airway inflammation induced by subsequent intranasal challenge2013

    • Author(s)
      Kamijo S, Takai T, Hara M, Matsuda H, Matsuda A, Saito H, Nakae S, Ichikawa S, Ogawa H, Okumura K
    • Organizer
      日本免疫学会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2013 Research-status Report
  • [Presentation] プロテアーゼアレルゲンによる経皮的感作はプロテアーゼ活性依存的にIgE/IgG産生を誘導する

    • Author(s)
      清村咲子、高井敏朗、飯田秀雄、上條清嗣、越智啓乃、丸山奈津子、原むつ子、小川秀興、池田志斈、奧村康
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] シンポジウム3:アレルギーにおける自然免疫応答.プロテアーゼアレルゲンによるIgE産生と気道炎症の誘導

    • Author(s)
      上條清嗣、高井敏朗、中江進、齋藤博久、奧村康
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] アレルギー診療に役立つ免疫講座1.アレルゲンが引き起こすバリア破壊と自然免疫応答

    • Author(s)
      高井敏朗
    • Organizer
      日本アレルギー学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 順天堂大学大学院医学研究科 アトピー疾患研究センター

    • URL

      http://www.juntendo.ac.jp/graduate/laboratory/labo/atopy_center/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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