| Project/Area Number |
25461714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAYAMA Yoshimiti 日本大学, 医学部, 准教授 (80292605)
HAYAMA Koremasa 日本大学, 医学部, 助教 (40647187)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 蕁麻疹 / マスト細胞 / FcεRI / MrgX2 / 神経ペプチド / 慢性蕁麻疹 / 自己抗体 / 皮膚 / アレルギー / 病態 / 新規診断法 |
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| Outline of Final Research Achievements |
Chronic urticaria is characterized by the occurrence of the spontaneous emergence of wheals and a flare reaction lasting for more than 4 weeks, which is so called chronic spontenious urticaria (CSU). Its pathogenesis is still unclear, while part of it is involved with autoimmunity. Several activation factors which are independent of IgE-allergen pathway are supposed, and substance P (SP) is one of them. In this study, firstly we identified that anti-FcεRIα antibody is able to detect by ELISA and which titer is higher in sever CSU patients which symptoms were continuous without medication. Secondary, we identify that expression of MrgX2 in skin mast cells of patients with CSU are significantly greater than those in NC subjects, and SP induce skin mast cell activation through MrgX2.
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