Development of new immunotherapy through activation of Langerhans cells
| Project/Area Number |
25461715
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Takahashi Hidemi 日本医科大学, 医学(系)研究科(研究院), 教授 (40221361)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Langerhans cells / Dendritic cells / Langerin / DC-SIGN / DEC-205 / cross-presentation / α-galactosylceramide / Langerhans細胞（LC） / 樹状細胞（DC） / toll-like receptors / E-cadherin / CD14陽性細胞 / CD34陽性臍帯血細胞 / TLRs / cord blood / Birbeck顆粒 |
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| Outline of Final Research Achievements |
Langerhans cells (LC) belong to dendritic cell lineage, and mainly reside within surface compartment such as skin and mucosa. Similar to keratinocytes (KCs) within the skin, the LCs express E-cadherin, by which LC are tethered within the skin and search external foreign antigenic molecules through their unique receptor, langerin. LCs also express DEC-205 molecules and the DEC-205-positive cells have the capacity to present processed antigenic fragment from external antigens through class I MHC molecules to suitable T cells. Here, we found α-galactosylceramide (α-GalCer), a known stimulant for natural killer T (NKT) cells, efficiently activate the DEC-205-positive DCs/LCs and induce cellular immunity organized by cytotoxic T lymphocytes (CTLs) that eliminate virus-infected cells and cancer cells.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Hemopoietic cell kinase (Hck) and p21-activated kinase 2 (PAK2) are involved in the down-regulation of CD1a lipid antigen presentation by HIV-1 Nef in dendritic cells.2016
Author(s)
Shinya, E., Shimizu, M., Owaki, A., Paoletti, S., Mori, L., De Libero, G., and Takahashi, H.
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Journal Title
Virology
Volume: 487
Pages: 285-295
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Effects of dendritic cell subset manipulation on airway allergy in a mouse model.2016
Author(s)
Murakami, R., Nakagawa, Y., Shimizu, M., Wakabayashi, A., Negishi, Y., Hiroi, T., Okubo, K., and Takahashi, H.
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Journal Title
Int Arch Allergy Immunol
Volume: 168
Pages: 219-232
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Effect of extracellular pH and hypoxia on the function and development of antigen-specific cytotoxic T lymphocytes.2015
Author(s)
Nakagawa, Y., Negishi, Y., Shimizu, M., Takahashi, M., Ichikawa, M., and Takahashi, H.
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Journal Title
Immunol. Lett.
Volume: 167
Pages: 72-86
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A possible origin of emerged HIV-1 after interrupting anti-retroviral therapy2014
Author(s)
Matsumura, J., Shimizu, M., Omi, K., Nagata, N., Shyinya, E., Oka, S., and Takahashi, H.
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Journal Title
Biomed. Res.
Volume: 35
Pages: 1-8
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Inhibition of R5-tropic human immunodeficiency virus type-1 replication in CD4+ natural killer T cells by gamma-delta T lymphocytes2014
Author(s)
Omi, K., Shimizu, M., Watanabe, E., Matsumura, J., Takaku, C., Shinya, E., and Takahashi, H.
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Journal Title
Immunology
Volume: 141
Pages: 596-608
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] <b>A low, non-toxic dose of paclitaxel can prevent dendritic cell-precursors from becoming tolerogenic dendritic cells with impaired </b><b>functions </b>2014
Author(s)
Matsuhashi, T., Shimizu, M., Negishi, Y., Takeshita, T., and Takahashi, H.
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Journal Title
Biomed. Res.
Volume: 35
Issue: 6
Pages: 369-380
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A possible origin of emerged HIV-1 after interrupting anti-retroviral therapy.2014
Author(s)
Matsumura, J., Shimizu, M., Omi, K., Nagata, N., Shinya, E., Oka, S., and Takahashi, H.
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Journal Title
Biomed. Res.
Volume: 35
Pages: 1-8
NAID
Related Report
Peer Reviewed
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[Presentation] Non-toxic dose of paclitaxel can prevent dendritic cell-precursors from becoming tolerogenic dendritic cells with impaired functions.2014
Author(s)
Takahashi H., Matsuhashi, T., Shimizu, M., Kohgo, T., Date, T., Negishi, Y., Takeshita, T.
Organizer
第43回日本免疫学会学術集会
Place of Presentation
京都
Year and Date
2014-12-10 – 2014-12-12
Related Report
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[Presentation] 免疫と漢方2014
Author(s)
高橋秀実
Organizer
日本東洋医学会北陸支部総会
Place of Presentation
金沢
Year and Date
2014-10-18 – 2014-10-19
Related Report
Invited
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[Presentation] 免疫と漢方2014
Author(s)
高橋秀実
Organizer
日本東洋医学会兵庫県支部総会
Place of Presentation
神戸
Year and Date
2014-10-05
Related Report
Invited
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[Presentation] Manipulation of rapid apoptosis for HIV-1 gp160-specific murine CD8+ CTLs by free antigenic peptide in vivo.2013
Author(s)
Takahashi H. Shimizu, M., Norose, Y., Takaku, S., Takahashi, M., Nakagawa, Y.
Organizer
15th International Congress of Immunology
Place of Presentation
Milan, Italy
Related Report
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[Presentation] E-cadherin interactions promote Langerhans cell differentiation.2013
Author(s)
Takahashi, H., Komiya, N., Koike, E., Azuma, H., Otsuka, Y., Watari, E., Kawana, S., Geijtenbeek Teunis, B. H.
Organizer
第42回日本免疫学会学術集会
Place of Presentation
幕張市
Related Report
Invited
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