Analysis of immunological mechanisms and therapeutic approach for prurigo, itch, and other pruritic skin diseases
Project/Area Number |
25461719
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
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Research Institution | National Defense Medical College |
Principal Investigator |
Satoh Takahiro 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 教授 (30235361)
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Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Takashi 東京医科歯科大学, 大学院医歯学総合研究科・皮膚科学分野, 助教 (00647844)
FURUYA Aiko 済生会川口病院, 皮膚科, 医師 (30622972)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 痒疹 / 好塩基球 / STAT6 / そう痒 / 好酸球 / 痒み / TSLP / ERK |
Outline of Final Research Achievements |
We established a mouse model of prurigo. Skin lesions were characterized by irregular acanthosis and dermal eosinophils, mononuclear cells, and basophils, with epidermal nerve fiber sprouting. In vivo depletion of basophils alleviated skin reactions. Unexpectedly, deficiency of STAT6 caused exacerbation of skin inflammation. Notably, decreased scratching behaviors were associated with reduced tissue eosinophils, despite exacerbated inflammation. We also analyzed human prurigo patients. Epidermal keratinocytes expressed TLSP and IL-33 in all groups. There was no close association between prurigo and malignancy or metal allergy. In a patient with pruritus cutaneus due to sclerosing cholangitis, serum levels of autotaxin , a synthetic enzyme for lysophosphatidic acid (LPA), and histamine correlated with pruritus. Blood cells produced histamine in response to LPA in vitro. Thus, LPA appeared to contribute to cholestatic pruritus via stimulating basophils to produce histamine.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility2014
Author(s)
Sakiyama, M. Matsuo, H. Shimizu, S. Chiba, T. Nakayama, A. Takada, Y. Nakamura, T. Takada, T. Morita, E. Naito, M. Wakai, K. Inoue, H. Tatsukawa, S. Sato, J. Shimono, K. Makino, T. Satoh, T. Suzuki, H. Kanai, Y. Hamajima, N. Sakurai, Y. Ichida, K. Shimizu, T. Shinomiya, N.
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Journal Title
Hum Cell
Volume: 27(1)
Issue: 1
Pages: 1-4
DOI
Related Report
Peer Reviewed
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[Presentation] 痒疹の病態と痒み2015
Author(s)
佐藤貴浩
Organizer
第45回日本皮膚アレルギー・接触皮膚炎学会
Place of Presentation
松江
Year and Date
2015-12-13
Related Report
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