The functional analysis of Chromogranin in the neuropsychiatric diseases

• Project/Area Number: 25461722
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Neuropsychiatric Research Institute (2014-2015); University of Tsukuba (2013)
• Principal Investigator: Iijima Yoshimi 公益財団法人神経研究所, 研究部, 研究員 (70574648)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: バイオストレスマーカー / 統合失調症 / 筋萎縮性側索硬化症 / 精神神経化学 / 精神神経科学

Outline of Final Research Achievements

In our previous genome-wide association studies, a significant association with schizophrenia was observed at the chromogranin B (CHGB) gene locus. CHGB is a widespread family of proteins in the neurosystem, whose function is guiding the sorting and secretion of neuropeptides. In this study, I performed analyses as follows: ①The behavioral analyses of chgb-KO mice, ②The functional analyses of CHGB in the amyotrophic lateral sclerosis (ALS) using genetically modified mice, ③ The relationship between psychological stress symptoms and the gene variation of CHGB.

Research Products

• [Journal Article] A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population (2015)
  • Author(s): Choi Y, Miura M, Nakata Y, Sugasawa T, Nissato S, Otsuki T, Sugawara J, Iemitsu M, Kawakami Y, Shimano H, Iijima Y, Tanaka K, Kuno S, Allu PK, Mahapatra NR, Maeda S, Takekoshi K.
  • Journal Title: Endocrine Journal Volume: 62 Issue: 9 Pages: 797-804
  • DOI: 10.1507/endocrj.EJ14-0471
  • NAID: 130005100640
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Experimental Evidence for the Involvement of PDLIM5 in Mood Disorders in Hetero Knockout Mice. (2013)
  • Author(s): Horiuchi Y, Ishikawa M, Kaito N, Iijima Y, Tanabe Y, Ishiguro H, Arinami T.
  • Journal Title: PLoS One. Volume: 8 Issue: 4 Pages: e59320-e59320
  • DOI: 10.1371/journal.pone.0059320
  • NAID: 120007136961
  • Peer Reviewed
• [Journal Article] Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia (2013)
  • Author(s): Watanabe, Y., Iijima, Y., Egawa, J., Nunokawa, A., Kaneko, N., Arinami, T., Ujike, H., Inada, T., Iwata, N., Kunugi, H., Itokawa, M., Sasaki, T., Ozaki, N., Hashimoto, R., Shibuya, M., Igeta, H., Someya, T.
  • Journal Title: Schizophrenia Research Volume: 150 Issue: 2-3 Pages: 596-597
  • DOI: 10.1016/j.schres.2013.08.028
  • Peer Reviewed
• [Presentation] TPH2遺伝子と日本人統合失調症との2段階関連解析 (2014)
  • Author(s): 布川綾子、渡部雄一郎、飯嶋良味、他
  • Organizer: 第36回日本生物学的精神医学会
  • Place of Presentation: 奈良県 奈良市
  • Year and Date: 2014-09-29
• [Presentation] Relationships between psychological stress symptom and blood Chromogranin B (CHGB) level. (2013)
  • Author(s): Iijima Y, Kuriyama Y, Hori H, Hattori K, Yamamoto N, Matsuo J, Kunugi H, Arinami T
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan