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The functional analysis of Chromogranin in the neuropsychiatric diseases

Research Project

Project/Area Number 25461722
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNeuropsychiatric Research Institute (2014-2015)
University of Tsukuba (2013)

Principal Investigator

Iijima Yoshimi  公益財団法人神経研究所, 研究部, 研究員 (70574648)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsバイオストレスマーカー / 統合失調症 / 筋萎縮性側索硬化症 / 精神神経化学 / 精神神経科学
Outline of Final Research Achievements

In our previous genome-wide association studies, a significant association with schizophrenia was observed at the chromogranin B (CHGB) gene locus. CHGB is a widespread family of proteins in the neurosystem, whose function is guiding the sorting and secretion of neuropeptides. In this study, I performed analyses as follows: ①The behavioral analyses of chgb-KO mice, ②The functional analyses of CHGB in the amyotrophic lateral sclerosis (ALS) using genetically modified mice, ③ The relationship between psychological stress symptoms and the gene variation of CHGB.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (5 results)

All 2015 2014 2013

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] A common genetic variant of the chromogranin A-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population2015

    • Author(s)
      Choi Y, Miura M, Nakata Y, Sugasawa T, Nissato S, Otsuki T, Sugawara J, Iemitsu M, Kawakami Y, Shimano H, Iijima Y, Tanaka K, Kuno S, Allu PK, Mahapatra NR, Maeda S, Takekoshi K.
    • Journal Title

      Endocrine Journal

      Volume: 62 Issue: 9 Pages: 797-804

    • DOI

      10.1507/endocrj.EJ14-0471

    • NAID

      130005100640

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Experimental Evidence for the Involvement of PDLIM5 in Mood Disorders in Hetero Knockout Mice.2013

    • Author(s)
      Horiuchi Y, Ishikawa M, Kaito N, Iijima Y, Tanabe Y, Ishiguro H, Arinami T.
    • Journal Title

      PLoS One.

      Volume: 8 Issue: 4 Pages: e59320-e59320

    • DOI

      10.1371/journal.pone.0059320

    • NAID

      120007136961

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Replication in a Japanese population that a MIR30E gene variation is associated with schizophrenia2013

    • Author(s)
      Watanabe, Y., Iijima, Y., Egawa, J., Nunokawa, A., Kaneko, N., Arinami, T., Ujike, H., Inada, T., Iwata, N., Kunugi, H., Itokawa, M., Sasaki, T., Ozaki, N., Hashimoto, R., Shibuya, M., Igeta, H., Someya, T.
    • Journal Title

      Schizophrenia Research

      Volume: 150 Issue: 2-3 Pages: 596

    • DOI

      10.1016/j.schres.2013.08.028

    • URL

      https://pure.teikyo.jp/en/publications/7f7bdc70-c650-44f4-a718-fb423376294f

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] TPH2遺伝子と日本人統合失調症との2段階関連解析2014

    • Author(s)
      布川綾子、渡部雄一郎、飯嶋良味、他
    • Organizer
      第36回日本生物学的精神医学会
    • Place of Presentation
      奈良県 奈良市
    • Year and Date
      2014-09-29
    • Related Report
      2014 Research-status Report
  • [Presentation] Relationships between psychological stress symptom and blood Chromogranin B (CHGB) level.2013

    • Author(s)
      Iijima Y, Kuriyama Y, Hori H, Hattori K, Yamamoto N, Matsuo J, Kunugi H, Arinami T
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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