Fatty acid composition in the postmortem frontal cortex of patients with schizophrenia: A case-control study

• Project/Area Number: 25461726
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Toyama
• Principal Investigator: Hamazaki Kei 富山大学, 大学院医学薬学研究部(医学), 准教授 (50533494)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Takeo 独立行政法人理化学研究所, 分子精神科学研究チーム, チームリーダー (30249958)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 統合失調症 / 多価不飽和脂肪酸 / 脂肪酸結合蛋白 / 死後脳 / ケース・コントロール研究

Outline of Final Research Achievements

Abnormal levels of n-3 polyunsaturated fatty acids (PUFAs), particularly docosahexaenoic acid (DHA), have been found in the postmortem frontal cortex, particularly the orbitofrontal cortex, of patients with schizophrenia. Altered mRNA expression of fatty acid binding protein (FABP) 5 and FABP7 has likewise been reported. This study investigated whether PUFAs in the frontal cortex [Brodmann area (BA) 8] and mRNA expression of FABP3, 5, and 7 were different between patients with schizophrenia (n = 95) and unaffected controls (n= 93). No significant differences were found in DHA between the groups. Although arachidonic acid (AA) levels were significantly decreased in the schizophrenia group, no association was found between AA and schizophrenia on logistic regression analysis. Only FABP3 expression was significantly lower in the schizophrenia group than in the control group.

Research Products

• [Int'l Joint Research] The University of Melbourne(Australia)
• [Journal Article] Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study. (2016)
  • Author(s): Hamazaki K, Maekawa M, Toyota T, Iwayama Y, Dean B, Hamazaki T, Yoshikawa T
  • Journal Title: Schizophr Res. Volume: 171 Issue: 1-3 Pages: 225-32
  • DOI: 10.1016/j.schres.2016.01.014
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder. (2015)
  • Author(s): Hamazaki K, Maekawa M, Toyota T, Dean B, Hamazaki T, Yoshikawa T.
  • Journal Title: Psychiatry Research Volume: 印刷中 Issue: 2-3 Pages: 353-9
  • DOI: 10.1016/j.psychres.2015.01.004
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 統合失調症の死後脳前頭葉における脂肪酸組成について (2014)
  • Author(s): 浜崎景，前川素子，豊田倫子，Brian Dean，浜崎 智仁，吉川武男
  • Organizer: 日本脂質栄養学会第23回大会
  • Place of Presentation: 東京
  • Year and Date: 2014-08-29 – 2014-08-30
• [Presentation] A Case-control Study for Fatty Acid Composition of the Postmortem Prefrontal Cortex from Patients with Schizophrenia. (2014)
  • Author(s): Hamazaki K, Maekawa M, Toyota T, Dean B, Hamazaki T, Yoshikawa T
  • Organizer: 11th Congress of the International Society for the Study of Fatty Acids and Lipids
  • Place of Presentation: ストックホルム
  • Year and Date: 2014-06-28 – 2014-07-02
• [Presentation] A Case-control Study for Fatty Acid Composition of the Postmortem Prefrontal Cortex from Patients with Schizophrenia (2014)
  • Author(s): Kei Hamazaki, Motoko Maekawa, Tomoko Toyota, Brian Dean,Tomohito Hamazaki, Takeo Yoshikawa
  • Organizer: The 2nd International Society for Nutritional Psychiatry Research
  • Place of Presentation: メルボルン（オーストラリア）