| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We investigated the association between genetics and clinical or social outcomes of about 500 patients with schizophrenia at the critical period. Among 7 SNPs of 6 genes (SLC6A5, DTNBP1, GRM7, PPP3CC, EGR3, and PDE4B) which participated in NMDA receptor function, rs894747 of SLC6A5 gene was related to severity of illness and social outcome. Rs472952 of PDE4B gene was related to low score of letter fluency test. In 91SNPs of GWAS analysis of Japanese patients with schizophrenia, each 3SNPs including rs2623659 of CSMD1 was related to severity of illness or social outcome. 3SNPs ralated with severity of illness was also related to treatment resistance. It is interesting that the genetic factor also influenced to the clinical or social outcomes of the patients with schizophrenia.
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