| Project/Area Number |
25461733
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | Nagasaki University |
|---|
Principal Investigator |
KUROTAKI Naohiro 長崎大学, 医歯薬学総合研究科(医学系), 講師 (20423634)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OZAWA Hiroki 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50260766)
IMAMURA Akira 長崎大学, 医歯薬学総合研究科(医学系), 教授 (40325642)
YOSHIURA Kouichiro (MISHIMA Hiroyuki) 長崎大学, 原爆後障害医療研究所, 教授 (00304931)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ONO Shinji 長崎大学, 医歯薬学総合研究科(医学系), 講師 (70418820)
ICHINOSE Hitoshi 長崎大学, 医歯薬学総合研究科(医学系), 助教 (60404216)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | ミッシングヘリタビリティー / 遺伝子 / マイクロアレイ / 精神疾患 / 希少変異仮説 / ミッシング・ヘリタビリティー |
|---|
| Outline of Final Research Achievements |
Psychiatric diseases including schizophrenia,and mood disorders, are considered to the genetic background. A lot of from genome-wide association study (GWAS) have been performed based on common disease-common variant hypothesis so far. Susceptibility genes directly linked to the appropriate treatment, however, have not been discovered. In this situation, we analyzed familial cases struggled with schizophrenia. One family we found in relatively isolated local area in Nagasaki, is over three generations and has 13 patients with SCZ among of 35 individuals. G-band staining of a patient does show normal karyotype, 46,XY, and microarray analysis dose not detect structural abnormality such as chromosomal deletion and duplication. But, by exome sequencing using next generation sequencer and going through filtering step, just two genes have been detected to have gene alterations. We continue functional assay genes that we identified.
|
