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Lithium in drinking water and suicide prevention: a survey of JAPAN

Research Project

Project/Area Number 25461734
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOita University

Principal Investigator

ISHII Nobuyoshi  大分大学, 医学部, 講師 (00555063)

Co-Investigator(Kenkyū-buntansha) 寺尾 岳  大分大学, 医学部, 教授 (80217413)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsリチウム / 自殺率 / 水道水 / 自殺 / 人間生活環境 / 水資源 / 抗自殺効果
Outline of Final Research Achievements

The aim of the present study was to investigate the association between lithium levels of tap water and suicide rate with adjustment of potential factors affecting suicide in all 785 cities and 23 wards of Tokyo in all over Japan. Standardized mortality rates (SMRs) of suicide for 2010-2015 were averaged and used for suicide rates. Multiple regression analyses were performed to predict total SMRs, male SMRs, and female SMRs using lithium levels of tap water of 808 cities/wards, 8 districts (Hokkaido, Tohoku, Kanto, Chubu, Kinki, Chugoku, Shikoku, Kyushu), and interactions between lithium levels and individual districts as independent factors. As a result, lithium levels significantly and inversely predicted male suicide SMRs, but not female suicide SMRs. The present findings suggest that lithium in tap water may be inversely associated with male suicide rate.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report

Research Products

(16 results)

All 2016 2015 2014 2013

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (7 results) (of which Invited: 5 results) Book (2 results)

  • [Journal Article] 双極性障害における自殺と気分安定薬のリスク・ベネフィット2016

    • Author(s)
      寺尾 岳
    • Journal Title

      臨床精神薬理

      Volume: 19 Pages: 1111-1116

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Trace lithium is inversely associated with male suicide after adjustment of climatic factors.2016

    • Author(s)
      Shiotsuki I, Terao T, Ishii N, Takeuchi S, Kuroda Y, Kohno K, Mizokami Y, Hatano K, Tanabe S, Kanehisa M, Iwata N, Matusda S.
    • Journal Title

      The Journal of Affective Disorders

      Volume: 189 Pages: 282-286

    • DOI

      10.1016/j.jad.2015.09.070

    • Related Report
      2015 Research-status Report
  • [Journal Article] Low Risk of Male Suicide and Lithium in Drinking Water2015

    • Author(s)
      2.Nobuyoshi Ishii, Takeshi Terao, Yasuo Araki, Kentaro Kohno, Yoshinori Mizokami, Ippei Shiotsuki, Koji Hatano, Mayu Makino, Kensuke Kodama, Noboru Iwata
    • Journal Title

      The Journal of Clinical Psychiatry

      Volume: 76 Pages: 319-26

    • DOI

      10.4088/jcp.14m09218

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lithium in Drinking Water for Dementia and Suicide2014

    • Author(s)
      Terao T, Ishii N and Shiotsuki I
    • Journal Title

      Austin Journal of Psychiatry and Behavioral Science

      Volume: 1 Pages: 2-2

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lithium in Tap Water and Suicide Mortality in Japan.2013

    • Author(s)
      Norio Sugawara,Norio Yasui-Furukori,Nobuyoshi Ishii,Noboru Iwata,Takeshi Terao
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 10 Pages: 6044-6048

    • DOI

      10.3390/ijerph10116044

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk factors for suicide in Japan: A model of predicting suicide in 2008 by risk factors of 20072013

    • Author(s)
      Ishii N, Terao T, Araki Y, Kohno K, Mizokami Y, Arasaki M, Iwata N
    • Journal Title

      Journal of Affective Disorders

      Volume: 147(1-3) Pages: 352-354

    • DOI

      10.1016/j.jad.2012.11.038

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] リチウムの自殺予防作用2013

    • Author(s)
      寺尾岳、石井啓義、塩月一平
    • Journal Title

      臨床精神医学

      Volume: 42(11) Pages: 1381-1387

    • Related Report
      2013 Research-status Report
  • [Presentation] 日本全国を対象とした、水道水に含まれる微量なリチウムと自殺率低下の関連性2016

    • Author(s)
      石井 啓義
    • Organizer
      第26回日本臨床精神神経薬理学会
    • Place of Presentation
      ホルトホール大分(大分県・大分市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 生活習慣とメンタルヘルス:光と水と青魚2016

    • Author(s)
      寺尾 岳
    • Organizer
      第26回日本臨床精神神経薬理学会
    • Place of Presentation
      ホルトホール大分(大分県・大分市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 微量なリチウムと自殺予防2016

    • Author(s)
      寺尾 岳
    • Organizer
      第46回日本神経精神薬理学会年会
    • Place of Presentation
      ソウル(大韓民国)
    • Year and Date
      2016-07-02
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Low risk of male suicide and lithium in drinking water2015

    • Author(s)
      石井啓義
    • Organizer
      日本臨床精神神経薬理学会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2015-10-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 水道水リチウムと自殺予防:北海道35市における調査と九州との比較2015

    • Author(s)
      塩月一平, 寺尾岳, 石井啓義, 溝上義則, 河野健太郎, 秦野浩司, 田邉三思, 兼久雅之, 帆秋伸彦, 岩田昇
    • Organizer
      リチウム研究会
    • Place of Presentation
      経団連会館(東京都千代田区)
    • Year and Date
      2015-04-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Lithium Levels in Drinking Water and Risk of Suicide: Kyushu Island Study2013

    • Author(s)
      Takeshi Terao
    • Organizer
      10th INTERNATIONAL CONFERENCE ON BIPOLAR DISORDERS
    • Place of Presentation
      アメリカ
    • Related Report
      2013 Research-status Report
  • [Presentation] 水道水リチウムと自殺予防2013

    • Author(s)
      石井啓義、寺尾岳、児玉健介、秦野浩司、河野健太郎、荒木康夫、原田麻友、溝上義則
    • Organizer
      第32回リチウム研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] Bipolar Disorder 11「薬物療法からみた自殺予防」2013

    • Author(s)
      寺尾 岳
    • Publisher
      アルタ出版株式会社
    • Related Report
      2013 Research-status Report
  • [Book] 精神と栄養~メンタルヘルスの新たな視点~「水道水に含まれる微量なリチウムの自殺予防効果」2013

    • Author(s)
      寺尾 岳
    • Publisher
      株式会社医薬ジャーナル社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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