Role of calcium ion-dependent signaling pathway in the perirhinal cortical neurons related to visual memory

• Project/Area Number: 25461735
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Health Sciences University of Hokkaido (2015-2016); University of Miyazaki (2013-2014)
• Principal Investigator: ABE Hiroshi 北海道医療大学, 心理科学部, 准教授 (20344848)
• Co-Investigator(Kenkyū-buntansha): 石田 康 宮崎大学, 医学部, 教授 (20212897) ; 池田 哲也 宮崎大学, 医学部, 准教授 (20264369)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 視覚性記憶 / 嗅周皮質 / シグナル伝達 / アネキシン / 視覚性弁別学習 / 弁別学習

Outline of Final Research Achievements

Memory impairment in Alzheimer's disease is associated with lesion of the perirhinal cortex. The calcium ion-dependent information transmission in this cortex is indispensable for the visual memory. In this study, we aimed to examine the behavioral and morphological relationships between annexin AII and visual memory associated with one of the calcium - dependent signal transduction pathways. The operant conditioning was used to make rats learn the visual memory task. This was impaired by damage of the perirhinal cortex. However, annexin AII in this cortex was not so involved in this memory, suggesting that other signal transduction pathways might play an important role.

Research Products

• [Journal Article] Yokukansan, a Traditional Japanese Medicine, Enhances the L-DOPA-Induced Rotational Response in 6-Hydroxydopamine-Lesioned Rats: Possible Inhibition of COMT (2016)
  • Author(s): Yasushi Ishida, Kosuke Ebihara, Masahiro Tabuchi, Sachiko Imamura, Kyoji Sekiguchi, Kazushige Mizoguchi, Yoshio Kase, Go Koganemaru, Hiroshi Abe, Yasushi Ikarashi
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 1 Pages: 104-113
  • DOI: 10.1248/bpb.b15-00691
  • NAID: 130005116498
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Pramipexole reduces parkinsonian tremor induced by pilocarpine infusion in the rat striatum (2015)
  • Author(s): Yasuda K, Abe H, Koganemaru G, Ikeda T, Arimori K, Ishida Y
  • Journal Title: Pharmacol Biochem Behav Volume: 131 Pages: 1-5
  • DOI: 10.1016/j.pbb.2015.01.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Intrastriatal grafts of fetal ventral mesencephalon improve allodynia-like withdrawal response to mechanical stimulation in a rat model of Parkinson's disease (2014)
  • Author(s): Takeda R, Ishida Y, Ebihara K, Abe H, Matsuo H, Ikeda T, Koganemaru G, Kuramashi A, Funahashi H, Magata Y, Kawai K, Nishimori T
  • Journal Title: Neurosci Lett Volume: 573 Pages: 19-23
  • DOI: 10.1016/j.neulet.2014.05.007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats (2014)
  • Author(s): Koganemaru G, Abe H, Kuramashi A, Nishimori T, Ebihara K, Matsuo H, Funahashi H, Yasuda K, Ikeda T, Ishida Y
  • Journal Title: Pharmacol Biochem Behav Volume: 126 Pages: 103-108
  • DOI: 10.1016/j.pbb.2014.09.015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats (2013)
  • Author(s): Kuramashi A, Abe H, Koganemaru G, Matsuo H, Ikeda T, Ebihara K, Funahashi H, Takeda R, Nishimori T, Ishida Y
  • Journal Title: Neuroscience Letters Volume: 549 Pages: 97-102
  • DOI: 10.1016/j.neulet.2013.06.020
  • Peer Reviewed
• [Journal Article] アセチルコリンエステラーゼ阻害薬が誘発する不随意運動に対するドパミン受容体作動薬の効果 (2013)
  • Author(s): 小金丸剛，安部博史，倉増亜紀，蛯原功介，松尾寿栄，石田康
  • Journal Title: 脳21 Volume: 16 Pages: 372-372
• [Presentation] Effects of dopamine agonist, cabergoline on the tremulous jaw movements produced by the acetylcholinesterase inhibitor, tacrine, and their related patterns of c-Fos expression in the striatum. (2013)
  • Author(s): Koganemaru G, Abe H, Kuramashi A, Ebihara K, Matsuo H, Funahashi H, Yasuda K, Ikeda T, Takeda R, Nishimori T, Ishida Y
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: 京都
• [Presentation] Effects of dopamine receptor agonist, cabergoline or rotigotine on tremulous jaw movements induced by acetylcholinesterase inhibitor, tacrine. (2013)
  • Author(s): Koganemaru G, Abe H, Kuramashi A, Ebihara K, Matsuo H, Funahashi H, Yasuda K, Ikeda T, Takeda R, Nishimori T, Ishida Y
  • Organizer: 43th Annual Meeting Society for Neuroscience
  • Place of Presentation: San Diego, USA
• [Presentation] アセチルコリンエステラーゼ阻害薬が誘発する不随意運動に対するドパミン受容体作動薬の効果
  • Author(s): 小金丸剛，安部博史，倉増亜紀，蛯原功介，松尾寿栄，石田康
  • Organizer: 第20回カテコールアミンと神経疾患研究会
  • Place of Presentation: 東京
• [Book] Neurogenesis: Cell Biology, Regulation and Role in Disease" (2015)
  • Author(s): Hiroshi Abe, Noriko Hidaka, Chika Kawagoe, Kei Odagiri, Tetsuya Ikeda, Toshikazu Nishimori, and Yasushi Ishida
  • Total Pages: 30
  • Publisher: Nova Science Pub. Inc