The investigation for relation between the mechanism of P-glycoprotein and treatment-resistant schizophrenia effective Clozapin
Project/Area Number |
25461742
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | St. Marianna University School of Medicine |
Principal Investigator |
kenichi osada 聖マリアンナ医科大学, 医学部, 准教授 (20233504)
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Co-Investigator(Kenkyū-buntansha) |
貴家 康男 聖マリアンナ医科大学, 医学部, 助教 (60308450)
芳賀 俊明 聖マリアンナ医科大学, 医学部, 研究技術員 (80535625)
中野 三穂 聖マリアンナ医科大学, 医学部, 助教 (90621574)
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | P糖蛋白質 / 治療抵抗性統合失調症 / クロザピン / アリピプラゾール / ジゴキシン / P糖タンパク質 / P糖タンパク質 / ブロナンセリン |
Outline of Final Research Achievements |
P-glycoprotein (P-gp) influences the distribution of drugs across the blood-brain barrier, and is capable of transporting antipsychotic drugs such as aripiprazole and risperidone. Clozapine, which is used clinically for treatment-resistant schizophrenia, is not a P-gp substrate. C57BL/6 mice were orally administered aripiprazole, blonanserin, or clozapine at 10 mg/kg once daily for 6 weeks, and P-gp mRNA (Abcb1a/Abcb1b) and protein (Abcb1a/Abcb1b) expression levels were measured. This is the first report that chronic aripiprazole treatment increases P-gp mRNA and protein expression in animals, which is associated with the inhibition of digoxin excretion from the brain. These results suggest that increased P-gp expression induced by aripiprazole is mediated by its interaction with P-gp.
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Report
(5 results)
Research Products
(31 results)
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[Journal Article] 抗不安薬の適切な使用方法2014
Author(s)
長田賢一, 渡邉高志, 田口篤, 芳賀俊明, 武藤亜矢, 牛谷真由美, 柳田拓洋, 中野三穂, 貴家康男, 山口登.
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Journal Title
Modern Physician
Volume: 34(6)
Pages: 719-723
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[Presentation] 高齢者のうつ病について2015
Author(s)
長田 賢一
Organizer
日本社会精神医学会
Place of Presentation
富山国際会議場(富山県)
Year and Date
2015-03-05 – 2015-03-06
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Invited
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[Presentation] 双極性障害の症状と睡眠障害に対する検討2014
Author(s)
長田賢一, 牛谷真由美, 瀧沢絵里, 中野三穂, 渡邉高志, 田口篤, 芳賀俊明, 武藤亜矢, 貴家康男, 山口登
Organizer
日本睡眠学会第39回定期学術集会
Place of Presentation
あわぎんホール(徳島県)
Year and Date
2014-07-03 – 2014-07-04
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