| Project/Area Number |
25461744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
YAMADA Misa 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神薬理研究部, 科研費研究員 (10384182)
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| Co-Investigator(Kenkyū-buntansha) |
SAITOH AKIYOSHI 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神薬理研究部, 室長 (00366832)
HASHIMOTO TOMIO 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神薬理研究部, 流動研究員 (10610751)
YAMADA MITSUHIKO 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 精神薬理研究部, 部長 (60240040)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 精神薬理学 / 転写因子 / 遺伝子 / 抗うつ薬 / 情動行動調節 |
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| Outline of Final Research Achievements |
We previously reported that Prg1, the target gene of a transcription factor MATH2, was induced after chronic treatment with SSRI in mouse hippocampus. In the present study, we have demonstrated that LPA (i.c.v.), a lipid mediator inactivated by Prg1, induced emotional behaviors in mice. Prg1 was regulating the survival of neurons in the process of neurogenesis, which plays an important role in the antidepressive action. Finally, Prg1 expression was observed in NeuN-positive neurons but not with Nestin-positive neuronal stem cells in mouse dentate gyrus.
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