| Project/Area Number |
25461745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Inagaki Masumi 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所知的障害研究部, 部長 (70203198)
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| Co-Investigator(Kenkyū-buntansha) |
KAGA Makiko 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 客員研究員 (20142250)
OSAKABE Hitomi 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 研究補助員 (30625520)
LI Heng 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 流動研究員 (70621994)
OHTA Hidenobu 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 診断研究室長 (80422103)
SUGIURA Yuka (SHIRAKAWA Yuka) 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所・知的障害研究部, 流動研究員 (50750402)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Ken 国立研究開発法人国立精神・神経医療研究センター, 神経研究所・疾病研究第二部, 室長 (30392418)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 不安 / GABA神経系 |
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| Outline of Final Research Achievements |
The cause of anxiety disorders and the panic disorder has been unknown. We aimed to determine the gene responsible for mutant mice (bv) exhibiting behaviorally anxiety-like symptoms, and aimed to reveal the molecular mechanisms leading to anxiety disorders. As a result, the cause gene of bv mouse was proved to be Srrm4, which was an alternative splicing controlling element to develop only in neurons. It was confirmed that expression ratio of splicing variants of GABA A receptor γ2 subunit (Gabrg2) in adult mice are different from in the control group, and it was indicated that this gene was associated with human GABA nervous system function adjustment. Furthermore, we made the experiment system that we knocked down Srrm4 in a primary culture neuron.
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