| Project/Area Number |
25461747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUOKA Hiroo 東北大学, 医学系研究科, 教授 (00173815)
OHMURO Noriyuki 東北大学, 病院, 助教 (60632601)
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| Research Collaborator |
KATSURA Masahiro
OBARA Chika
KIKUCHI Tatsuro
IIZUKA Kunio
KOKUBUN Kyoko
ABE Koichi
HAMAIE Yumiko
SUNAKAWA Emi
SATO Shiori
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 早期介入 / 統合失調症 / 前駆期 / ARMS / 予防精神医学 / MRI / 神経画像 / 脳構造 / 社会機能 / 減弱精神病症候群 / 早期精神病 / 予防 / 認知機能 / 脳MRI |
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| Outline of Final Research Achievements |
In this study, we investigated chronic cases with at-risk mental state (ARMS) who did not transit to psychosis. Among 126 cases with ARMS, we examined clinical outcome of 58 cases who was interviewed 5.9 years after intake assessment and the relation of gray matter volume (GMV) determined by Magnetic Resonance Imaging (MRI) and symptomatic and social outcome at 6, 12, and 24 months after intake. Sixty-three percent of non-transited ARMS individuals was treated by psychiatrists and 54% took psychotropic agents, and 24% had poor social functioning. Many social and functional indicators could not differentiate the transited between non-transited cases with ARMS. Non-transited ARMS individuals with persistent impairment of social functioning had reduced GMV at baseline, indicating brain structural change may be a candidate of a prognostic indicator of long-term of outcome in individuals with ARMS.
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