A longitudinal follow-up study of at-risk mental state with chronic course
Project/Area Number |
25461747
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MATSUOKA Hiroo 東北大学, 医学系研究科, 教授 (00173815)
OHMURO Noriyuki 東北大学, 病院, 助教 (60632601)
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Research Collaborator |
KATSURA Masahiro
OBARA Chika
KIKUCHI Tatsuro
IIZUKA Kunio
KOKUBUN Kyoko
ABE Koichi
HAMAIE Yumiko
SUNAKAWA Emi
SATO Shiori
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 早期介入 / 統合失調症 / 前駆期 / ARMS / 予防精神医学 / MRI / 神経画像 / 脳構造 / 社会機能 / 減弱精神病症候群 / 早期精神病 / 予防 / 認知機能 / 脳MRI |
Outline of Final Research Achievements |
In this study, we investigated chronic cases with at-risk mental state (ARMS) who did not transit to psychosis. Among 126 cases with ARMS, we examined clinical outcome of 58 cases who was interviewed 5.9 years after intake assessment and the relation of gray matter volume (GMV) determined by Magnetic Resonance Imaging (MRI) and symptomatic and social outcome at 6, 12, and 24 months after intake. Sixty-three percent of non-transited ARMS individuals was treated by psychiatrists and 54% took psychotropic agents, and 24% had poor social functioning. Many social and functional indicators could not differentiate the transited between non-transited cases with ARMS. Non-transited ARMS individuals with persistent impairment of social functioning had reduced GMV at baseline, indicating brain structural change may be a candidate of a prognostic indicator of long-term of outcome in individuals with ARMS.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset2015
Author(s)
Shinya Ito, Takahiro Nemoto, Naohisa Tsujino, Noriyuki Ohmuro, Kazunori Matsumoto, Hiroo Matsuoka, Kodai Tanaka, Shimako Nishiyama, Michio Suzuki, Hirohisa Kinoshita, Hiroki Ozawa, Hirokazu Fujita, Shinji Shimodera, Toshifumi Kishimoto, Kunichika Matsumoto, Tomonori Hasegawa, Masafumi Mizuno
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Journal Title
European Psychiatry
Volume: 30
Issue: 8
Pages: 995-1001
DOI
Related Report
Peer Reviewed
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[Journal Article] 地域ケアの時代における精神疾患 早期発見・早期支援の課題と可能性2015
Author(s)
水野 雅文, 鈴木 道雄, 松本 和紀, 中込 和幸, 下寺 信次, 盛本 翼, 岸本 年史, 川崎 康弘, 舩渡川 智之, 根本 隆洋, 藤井 千代
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Journal Title
精神医学
Volume: 57
Pages: 89-103
NAID
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[Journal Article] 名取EIプロジェクト-宮城県立精神医療センターを中心とした早期介入プロジェクトについて-2013
Author(s)
大野高志,船越俊一,角藤芳久,谷口宏,高松杏子,野村綾,横川信弘,齋藤和子,香山明美,石黒奈々子,大室則幸,桂雅宏,濱家由美子,小高晃,松本和紀,松岡洋夫
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Journal Title
精神神経学雑誌
Volume: 115(2)
Pages: 147-153
NAID
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[Presentation] Quality of life in individuals with at-risk mental states and its relationship with psychiatric symptoms2014
Author(s)
Yuu Ishii, Noriyuki Ohmuro, Masahiro Katsura, Chika Obara, Yumiko Hamaie, Emi Sunakawa, Shiori Sato, Tomohiro Uchida, Kazunori Matsumoto, Takashi Ueno, Hiroo Matsuoka
Organizer
9th International Conference on Early Psychosis
Place of Presentation
東京、京王プラザホテル
Year and Date
2014-11-18
Related Report
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[Presentation] Longitudinal follow-up of criticism and depression among families of first-episode psychosis patients2014
Author(s)
Yumiko Hamaie, Noriyuki Ohmuro, Masahiro Katsura, Chika Obara, Tatuo Kikuchi, Emi Sunakawa, Fumiaki Ito, Tetsuo Miyakoshi, Hiroo Matsuoka, Kazunori Matsumoto
Organizer
4th Biennial Schizophrenia International Research Conference
Place of Presentation
Florence, Italy
Year and Date
2014-04-06
Related Report
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[Presentation] Clinical and functional course of youths at ultra-high risk for psychosis: outcomes of non-converters in Japan.2014
Author(s)
Masahiro Katsura, Noriyuki Ohumuro, Chika Obara, Tatsuo Kikuchi, Yumiko Hamaie, Emi Sunakawa, Fumiaki Ito, Tetsuo Miyakoshi, Atsushi Sakuma, Hiroo Matsuoka, Kazunori Matsumoto
Organizer
4th Biennial Schizophrenia International Research Conference
Place of Presentation
Florence, Italy
Year and Date
2014-04-06
Related Report
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[Presentation] At-Risk Mental State(ARMS)はいつまでARMSか? ~SAFEクリニックにおける予備的調査から~
Author(s)
加賀谷隼輔, 桂 雅宏, 小原千佳, 大室則幸, 菊池達郎, 濱家由美子, 砂川恵美, 越道理恵, 伊藤文晃, 宮越哲生,松本和紀, 松岡洋夫
Organizer
第17回日本精神保健・予防学会
Place of Presentation
東京
Related Report
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