Repetitive Transcranial Magnetic Stimulation study in eating disorders: examination in cognitive set-shifting abilities

• Project/Area Number: 25461750
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Chiba University
• Principal Investigator: Nakazato Michiko 千葉大学, 大学院医学研究院, 特任教授 (10334195)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 摂食障害 / 認知柔軟性 / 経頭蓋磁気刺激療法 / 発達障害 / セントラルコヒアレンス / 認知機能改善療法 / 前頭葉認知柔軟性 / 前頭葉脳血流 / 反復性経頭蓋磁気刺激法 / NIRS / rTMS / 国際研究者交流 / 前頭葉機能

Outline of Final Research Achievements

The aims of this study were to assess cerebral oxygenation change induced with rTMS and to assess the short-term impact of rTMS on food craving and other bulimic symptoms in patients with bulimia nervosa (BN). Eight women diagnosed with BN according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria participated in this study. We measured haemoglobin concentration changes in the DLPFC with near-infrared spectroscopy during cognitive tasks measuring self-regulatory control in response to food photo stimuli, both at baseline and after a single session of rTMS. Subjective ratings for food cravings demonstrated significant reduction. A significant decrease in cerebral oxygenation of the left DLPFC was also observed after a single session of rTMS. Measurement with NIRS after rTMS intervention may be applicable for discussing the mechanisms underlying rTMS modulation in patients with BN

Research Products

• [Int'l Joint Research] ロンドン大学精神医学研究所(英国)
• [Journal Article] 児童期・思春期のやせ―神経性やせ症と回避・制限性 (2017)
  • Author(s): 中里道子, 公家里依
  • Journal Title: 精神科治療学 Volume: 32 Pages: 111-116
• [Journal Article] Repetitive Transcranial Magnetic Stimulation Changes Cerebral Oxygenation on the Left Dorsolateral Prefrontal Cortex in Bulimia Nervosa: A Near-Infrared Spectroscopy Pilot Study. (2016)
  • Author(s): Sutoh C, Koga Y, Kimura H, Kanahara N, Numata N, Hirano Y, Matsuzawa D, Iyo M, Nakazato M, Shimizu E.
  • Journal Title: European Eating Disorders Review Volume: ２４（１） Issue: 1 Pages: 83-8
  • DOI: 10.1002/erv.2413
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns. (2015)
  • Author(s): .Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
  • Journal Title: J Eat Disord. Volume: 3(14) Pages: 1-10
  • Open Access / Acknowledgement Compliant
• [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns (2015)
  • Author(s): Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
  • Journal Title: J Eat Disord Volume: 3 Issue: 1 Pages: 14-14
  • DOI: 10.1186/s40337-015-0050-6
  • Peer Reviewed / Open Access
• [Journal Article] 摂食障害に対する反復性経頭蓋磁気刺激法の効果 (2014)
  • Author(s): 中里道子、木村大、金原信久、伊豫雅臣
  • Journal Title: 総合病院精神医学 Volume: 26(2) Pages: 145-153
  • Peer Reviewed
• [Journal Article] 摂食障害に対する反復性経頭蓋磁気刺激法の効果・難治例への適応について (2014)
  • Author(s): 中里道子、木村大、金原信久、伊豫雅臣
  • Journal Title: 総合病院精神医学 Volume: 26巻2号
  • NAID: 130006832775
  • Peer Reviewed
• [Presentation] 摂食障害に対する神経調節治療 (2016)
  • Author(s): 中里道子
  • Organizer: 第82回日本心身医学会東北地方会
  • Place of Presentation: 東北大学(宮城県仙台市）
  • Year and Date: 2016-02-20
  • Invited
• [Presentation] Evaluation of a Cognitive Remediation Therapy Group for Adolescents with Anorexia Nervosa: An Open Study. (2016)
  • Author(s): Kuge R, Yokota A, Numata N, Okuda T, Nakazato M.
  • Organizer: The 22nd International Association for Child and Adolescent Psychiatry and Allied professions World Congress (IACAPAP)
  • Place of Presentation: Calgary, Canada
  • Int'l Joint Research
• [Presentation] Comparison in set-shifting, central coherence abilities in patients with eating disorders, autistic spectrum disorders and healthy subjects (2015)
  • Author(s): .Nakazato M, Matsumoto J, Numata N, Okuda T, Asano K, Hirano Y, Iyo M, Shimizu E.
  • Organizer: Eating Disorders Research Society, 21th annual meeting
  • Place of Presentation: Taormina, Italy
  • Year and Date: 2015-09-17
  • Int'l Joint Research
• [Presentation] Negative correlation between skin conductance response and the severity in patients with bulimia nervosa (2015)
  • Author(s): Numata N, Hirano Y, Sutoh C, Nakazato M, Shimizu E
  • Organizer: The 13th World Congress of Biological Psychiatry
  • Place of Presentation: Athens, GR
  • Year and Date: 2015-06-15
  • Int'l Joint Research
• [Presentation] Training and effectiveness of guided self-help CBT for bulimia nervosa: a preliminary study in Chiba improving access to psychological therapists (iapt) project. (2015)
  • Author(s): Nakazato M, Setsu R, Asano K, Numata N, Tanaka M, Ibuki H, Yamamoto T, Hirano Y, Iyo M, Shimizu E.
  • Organizer: International Conference on Eating Disorders (ICED)
  • Place of Presentation: Boston, Masachusetts (The USA)
  • Year and Date: 2015-04-23 – 2015-04-25
• [Presentation] Training and effectiveness of guided self-help CBT for bulimia nervosa: a preliminary study in Chiba improving access to psychological therapists (Chiba IAPT) project. (2015)
  • Author(s): Nakazato M, Setsu R, Asano K, Numata N, Tanaka M, Ibuki H, Yamamoto T, Hirano Y, Iyo M, Shimizu E.
  • Organizer: International Conference on Eating disorders (ICED)
  • Place of Presentation: Boston, Massachusetts, USA
  • Year and Date: 2015-04-23
  • Int'l Joint Research
• [Presentation] Neurocognitive functioning and serum levels of precursor BDNF in people suffering from eating disorders. (2014)
  • Author(s): Nakazato M, Matsumoto J, Numata N, Setsu R, Hirano Y, Sutoh C, Matsuzawa D, Iyo M, Yokote K, Hashimoto K, Shimizu E.
  • Organizer: Eating Disorders Research Society(EDRS)
  • Place of Presentation: Sandiego, California (The USA)
  • Year and Date: 2014-10-09 – 2014-10-11
• [Presentation] Neuropsychological function in eating disorders: focus on response inhibition and decision-making ability. (2014)
  • Author(s): Matsumoto J, Nakazato M, Hirano Y, Murano S, Yokote K, Shimizu E.
  • Organizer: 44th European Association for Behavioural and Cognitive Therapies Congress
  • Place of Presentation: The Hague (The Netherlands)
  • Year and Date: 2014-09-10 – 2014-09-13
• [Presentation] Changes in cerebral blood flow after high-frequency repetitive transcranial magnetic stimulation on the left frontal lobe in bulimia nervosa: A preliminary near-infrared spectroscopy study. (2013)
  • Author(s): Nakazato M, Sutoh C, Kimura H, Koga Y, Matsuzawa D, Kanahara N, Hirano Y, Iyo M, Shimizu E.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto International Conference Center
• [Presentation] Serum BDNF, serum glutamate and cognitive impairment in patients suffering from eating disorders. Symposium: Progress in biological approaches for comprehension and treatment of eating disorders (2013)
  • Author(s): Nakazato M.
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto International Conference Center
• [Book] 新体系 看護学全書 精神看護学２ 精神障害をもつ人の看護 (2015)
  • Author(s): 中里道子(分担執筆）、岩崎弥生、渡邉博幸（編集）
  • Publisher: メジカルフレンド社
• [Remarks] 千葉大学子どものこころの発達教育研究センター
  • URL: http://www.chiba-u.ac.jp/class/rccmd/researcher/2016.ht
• [Remarks] 子どものこころの発達研究センター
  • URL: http://www.m.chiba-u.ac.jp/class/rccmd/researcher/result.html
• [Remarks] 千葉大学大学院医学研究院子どものこころの発達研究センター
  • URL: http://www.m.chiba-u.ac.jp/class/rccmd/