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Repetitive Transcranial Magnetic Stimulation study in eating disorders: examination in cognitive set-shifting abilities

Research Project

Project/Area Number 25461750
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

Nakazato Michiko  千葉大学, 大学院医学研究院, 特任教授 (10334195)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords摂食障害 / 認知柔軟性 / 経頭蓋磁気刺激療法 / 発達障害 / セントラルコヒアレンス / 認知機能改善療法 / 前頭葉認知柔軟性 / 前頭葉脳血流 / 反復性経頭蓋磁気刺激法 / NIRS / rTMS / 国際研究者交流 / 前頭葉機能
Outline of Final Research Achievements

The aims of this study were to assess cerebral oxygenation change induced with rTMS and to assess the short-term impact of rTMS on food craving and other bulimic symptoms in patients with bulimia nervosa (BN). Eight women diagnosed with BN according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria participated in this study. We measured haemoglobin concentration changes in the DLPFC with near-infrared spectroscopy during cognitive tasks measuring self-regulatory control in response to food photo stimuli, both at baseline and after a single session of rTMS. Subjective ratings for food cravings demonstrated significant reduction. A significant decrease in cerebral oxygenation of the left DLPFC was also observed after a single session of rTMS. Measurement with NIRS after rTMS intervention may be applicable for discussing the mechanisms underlying rTMS modulation in patients with BN

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results) Book (1 results) Remarks (3 results)

  • [Int'l Joint Research] ロンドン大学精神医学研究所(英国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] 児童期・思春期のやせ―神経性やせ症と回避・制限性2017

    • Author(s)
      中里道子, 公家里依
    • Journal Title

      精神科治療学

      Volume: 32 Pages: 111-116

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Repetitive Transcranial Magnetic Stimulation Changes Cerebral Oxygenation on the Left Dorsolateral Prefrontal Cortex in Bulimia Nervosa: A Near-Infrared Spectroscopy Pilot Study.2016

    • Author(s)
      Sutoh C, Koga Y, Kimura H, Kanahara N, Numata N, Hirano Y, Matsuzawa D, Iyo M, Nakazato M, Shimizu E.
    • Journal Title

      European Eating Disorders Review

      Volume: 24(1) Issue: 1 Pages: 83-8

    • DOI

      10.1002/erv.2413

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns.2015

    • Author(s)
      .Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      J Eat Disord.

      Volume: 3(14) Pages: 1-10

    • Related Report
      2015 Research-status Report
    • Open Access / Acknowledgement Compliant
  • [Journal Article] Comparison in decision-making between bulimia nervosa, anorexia nervosa, and healthy women: influence of mood status and pathological eating concerns2015

    • Author(s)
      Matsumoto J, Hirano Y, Numata N, Matsuzawa D, Murano S, Yokote K, Iyo M, Shimizu E, Nakazato M.
    • Journal Title

      J Eat Disord

      Volume: 3 Issue: 1 Pages: 14-14

    • DOI

      10.1186/s40337-015-0050-6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 摂食障害に対する反復性経頭蓋磁気刺激法の効果2014

    • Author(s)
      中里道子、木村大、金原信久、伊豫雅臣
    • Journal Title

      総合病院精神医学

      Volume: 26(2) Pages: 145-153

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 摂食障害に対する反復性経頭蓋磁気刺激法の効果・難治例への適応について2014

    • Author(s)
      中里道子、木村大、金原信久、伊豫雅臣
    • Journal Title

      総合病院精神医学

      Volume: 26巻2号

    • NAID

      130006832775

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 摂食障害に対する神経調節治療2016

    • Author(s)
      中里道子
    • Organizer
      第82回日本心身医学会東北地方会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2016-02-20
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Evaluation of a Cognitive Remediation Therapy Group for Adolescents with Anorexia Nervosa: An Open Study.2016

    • Author(s)
      Kuge R, Yokota A, Numata N, Okuda T, Nakazato M.
    • Organizer
      The 22nd International Association for Child and Adolescent Psychiatry and Allied professions World Congress (IACAPAP)
    • Place of Presentation
      Calgary, Canada
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison in set-shifting, central coherence abilities in patients with eating disorders, autistic spectrum disorders and healthy subjects2015

    • Author(s)
      .Nakazato M, Matsumoto J, Numata N, Okuda T, Asano K, Hirano Y, Iyo M, Shimizu E.
    • Organizer
      Eating Disorders Research Society, 21th annual meeting
    • Place of Presentation
      Taormina, Italy
    • Year and Date
      2015-09-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Negative correlation between skin conductance response and the severity in patients with bulimia nervosa2015

    • Author(s)
      Numata N, Hirano Y, Sutoh C, Nakazato M, Shimizu E
    • Organizer
      The 13th World Congress of Biological Psychiatry
    • Place of Presentation
      Athens, GR
    • Year and Date
      2015-06-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Training and effectiveness of guided self-help CBT for bulimia nervosa: a preliminary study in Chiba improving access to psychological therapists (iapt) project.2015

    • Author(s)
      Nakazato M, Setsu R, Asano K, Numata N, Tanaka M, Ibuki H, Yamamoto T, Hirano Y, Iyo M, Shimizu E.
    • Organizer
      International Conference on Eating Disorders (ICED)
    • Place of Presentation
      Boston, Masachusetts (The USA)
    • Year and Date
      2015-04-23 – 2015-04-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Training and effectiveness of guided self-help CBT for bulimia nervosa: a preliminary study in Chiba improving access to psychological therapists (Chiba IAPT) project.2015

    • Author(s)
      Nakazato M, Setsu R, Asano K, Numata N, Tanaka M, Ibuki H, Yamamoto T, Hirano Y, Iyo M, Shimizu E.
    • Organizer
      International Conference on Eating disorders (ICED)
    • Place of Presentation
      Boston, Massachusetts, USA
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neurocognitive functioning and serum levels of precursor BDNF in people suffering from eating disorders.2014

    • Author(s)
      Nakazato M, Matsumoto J, Numata N, Setsu R, Hirano Y, Sutoh C, Matsuzawa D, Iyo M, Yokote K, Hashimoto K, Shimizu E.
    • Organizer
      Eating Disorders Research Society(EDRS)
    • Place of Presentation
      Sandiego, California (The USA)
    • Year and Date
      2014-10-09 – 2014-10-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Neuropsychological function in eating disorders: focus on response inhibition and decision-making ability.2014

    • Author(s)
      Matsumoto J, Nakazato M, Hirano Y, Murano S, Yokote K, Shimizu E.
    • Organizer
      44th European Association for Behavioural and Cognitive Therapies Congress
    • Place of Presentation
      The Hague (The Netherlands)
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Changes in cerebral blood flow after high-frequency repetitive transcranial magnetic stimulation on the left frontal lobe in bulimia nervosa: A preliminary near-infrared spectroscopy study.2013

    • Author(s)
      Nakazato M, Sutoh C, Kimura H, Koga Y, Matsuzawa D, Kanahara N, Hirano Y, Iyo M, Shimizu E.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto International Conference Center
    • Related Report
      2013 Research-status Report
  • [Presentation] Serum BDNF, serum glutamate and cognitive impairment in patients suffering from eating disorders. Symposium: Progress in biological approaches for comprehension and treatment of eating disorders2013

    • Author(s)
      Nakazato M.
    • Organizer
      11th World Congress of Biological Psychiatry
    • Place of Presentation
      Kyoto International Conference Center
    • Related Report
      2013 Research-status Report
  • [Book] 新体系 看護学全書 精神看護学2 精神障害をもつ人の看護2015

    • Author(s)
      中里道子(分担執筆)、岩崎弥生、渡邉博幸(編集)
    • Publisher
      メジカルフレンド社
    • Related Report
      2015 Research-status Report
  • [Remarks] 千葉大学子どものこころの発達教育研究センター

    • URL

      http://www.chiba-u.ac.jp/class/rccmd/researcher/2016.ht

    • Related Report
      2015 Research-status Report
  • [Remarks] 子どものこころの発達研究センター

    • URL

      http://www.m.chiba-u.ac.jp/class/rccmd/researcher/result.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 千葉大学大学院医学研究院子どものこころの発達研究センター

    • URL

      http://www.m.chiba-u.ac.jp/class/rccmd/

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2022-02-03  

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