Clarification of self/other recognition in developmental disorders using multimodal brain imaging

• Project/Area Number: 25461751
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: Kawakubo Yuki 東京大学, 医学部附属病院, 助教 (40396718)
• Co-Investigator(Kenkyū-buntansha): ISHII Ayaka 東京大学, 医学部附属病院, 助教 (40609020)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 自閉症スペクトラム / 注意欠如多動性障害 / 近赤外線スペクトロスコピー / 磁気共鳴画像 / 注意欠陥多動性障害 / 神経科学 / 発達障害

Outline of Final Research Achievements

The differential diagnosis of autism spectrum disorders (ASDs) and attention deficit hyperactivity disorder (ADHD) based solely on symptomatic and behavioral assessments can be difficult, even for experts. Thus, the development of a neuroimaging marker that differentiates ASDs from ADHD would be an important contribution to this field. We assessed the differences in brain activation between adults with ASDs and ADHD using near-infrared spectroscopy (NIRS) and resting-state functional MRI. This study provides evidence of a difference activation during inhibitory control and resting state between adults with ASDs and ADHD. Thus, NIRS and MRI may be useful as an auxiliary tool for the differential diagnosis of such developmental disorders.

Research Products

• [Journal Article] 精神疾患の背景にある発達障害を見つけるアセスメントと支援 (2016)
  • Author(s): 川久保友紀
  • Journal Title: 臨床心理学 Volume: 16 Pages: 185-189
• [Journal Article] A Small Number of Abnormal Brain Connections Predicts Adult Autism Spectrum Disorder. (2015)
  • Author(s): .Yahata N, Morimoto J, Hashimoto R, Lisi G, Shibata K, Kawakubo Y, Kuwabara H, Kuroda M, Yamada T, Megumi F, Imamizu H, Náñez J, Takahashi H, Okamoto Y, Kasai K, Kato N, Sasaki Y, Watanabe T, Kawato M
  • Journal Title: Nat. Commun. Volume: 7 Issue: 1 Pages: 11254-11254
  • DOI: 10.1038/ncomms11254
  • NAID: 120005770754
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical and neural effects of six-week administration of oxytocin on core symptoms of autism. (2015)
  • Author(s): Watanabe T, Kuroda M, Kuwabara H, Aoki Y, Iwashiro N, Natsubori T, Takao H, Nippashi Y, Kawakubo Y, Kunimatsu A, Kasai K, Yamasue H.
  • Journal Title: Brain Volume: 138 Issue: 11 Pages: 3400-3412
  • DOI: 10.1093/brain/awv249
  • Peer Reviewed / Open Access
• [Journal Article] Neuroimaging-Aided Prediction of the Effect of Methylphenidate in Children with Attention-Deficit Hyperactivity Disorder: A Randomized Controlled Trial. (2015)
  • Author(s): Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Hamada K, Okuhata S, Kawasaki S, Kuwabara H, Shimada T, Todokoro A, Igarashi T, Watanabe K, Yamasue H, Kato N, Kasai K, Kano Y.
  • Journal Title: Neuropsychopharmacology Volume: 40 Pages: 2852-2852
  • Peer Reviewed / Open Access
• [Journal Article] Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial (2015)
  • Author(s): Aoki Y, Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Takao H, Kawakubo Y, Kasai K, Yamasue H
  • Journal Title: Mol Psychiatry Volume: 20 Issue: 4 Pages: 447-53
  • DOI: 10.1038/mp.2014.74
  • Peer Reviewed / Open Access
• [Journal Article] 心理アセスメント (2014)
  • Author(s): 川久保友紀
  • Journal Title: 精神科治療学 Volume: 29 Pages: 220-222
• [Journal Article] Kasai K (in press) Functional abnormalities in the left ventrolateral prefrontal cortex during a semantic fluency task, and their association with thought disorder in patients with schizophrenia (2014)
  • Author(s): Marumo K, Takizawa R, Kinou M,Kawasaki S, Kawakubo Y, Fukuda M
  • Journal Title: NeuroImage, in press Volume: 85 Pages: 518-526
  • DOI: 10.1016/j.neuroimage.2013.04.050
  • Peer Reviewed
• [Journal Article] Mitigation of Sociocommunicational Deficits of Autism Through Oxytocin-Induced Recovery of Medial Prefrontal Activity : A Randomized Trial (2013)
  • Author(s): Watanabe T, Abe O, Kuwabara H, Yahata N, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Takao H, Kawakubo Y, Kamio Y, Kato N, Miyashita Y, Kasai K, and Yamasue H
  • Journal Title: JAMA psychiatry Volume: 71 Issue: 2 Pages: 166-75
  • DOI: 10.1001/jamapsychiatry.2013.3181
  • Peer Reviewed / Open Access
• [Journal Article] Prefrontal activation during inhibitory control measured by near-infrared spectroscopy for differentiating between autism spectrum disorders and attention deficit hyperactivity disorder in adults (2013)
  • Author(s): Ishii-Takahashi A, Takizawa R, Nishimura Y, Kawakubo Y, Kuwabara H, Matsubayashi J, Hamada K, Okuhata S, Yahata N, Igarashi T, Kawasaki S, Yamasue H, Kato N, Kasai K, and Kano Y
  • Journal Title: Neuroimage : Clinical Volume: 4 Pages: 53-63
  • DOI: 10.1016/j.nicl.2013.10.002
  • Peer Reviewed
• [Journal Article] Altered metabolites in the plasma of autism spectrum disorder : a capillary electrophoresis time-of-flight mass spectroscopy study (2013)
  • Author(s): Kuwabara H, Yamasue H, Koike S, Inoue H, Kawakubo Y, Kuroda M, Takano Y, Iwashiro N, Natsubori T, Aoki Y, Kano Y, and Kasai K
  • Journal Title: PLOS ONE Volume: 8 Issue: 9 Pages: e73814-e73814
  • DOI: 10.1371/journal.pone.0073814
  • Peer Reviewed
• [Journal Article] Genetic influences on prefrontal activation during a verbal fluency task in adults: A twin study based on multichannel near-infrared spectroscopy. (2013)
  • Author(s): Sakakibara E, （途中19名）, Yamasue H, （以下9名）
  • Journal Title: Neuroimage Volume: Advanced online publication Pages: 508-517
  • DOI: 10.1016/j.neuroimage.2013.03.052
  • Peer Reviewed
• [Presentation] 成人期の発達障害に対する心理社会的アプローチ 認知行動療法と心理教育 (2015)
  • Author(s): 川久保友紀
  • Organizer: 日本LD学会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2015-10-11
• [Presentation] Impaired prefrontal activation in autism spectrum disorders and attention deficit hyperactivity disorder. (2014)
  • Author(s): Kawakubo Y
  • Organizer: The 2nd Asian Congress on ADHD
  • Place of Presentation: Tokyo, Japan
  • Invited
• [Presentation] シンポジウム発達障害キャリーオーバーへの支援：精神医学の臨床研究における発達の側面 (2013)
  • Author(s): 桑原 斉、川久保友紀、金生由紀子
  • Organizer: 第54回児童青年精神医学会
  • Place of Presentation: 札幌、北海道
  • Invited
• [Presentation] A Randomized Controlled Trial of a Cognitive-Behavioral Intervention for Emotion Regulation in Adults with High-functioning Autism Spectrum Disorders (2013)
  • Author(s): Kuroda M, Kawakubo Y, Kuwabara H, Kano Y, Kamio Y.
  • Organizer: Autism-Europe International Congresses
  • Place of Presentation: Budapest, Hungary
• [Presentation] AD/HD児童における塩酸メチルフェ二デート除放剤の短期および長期服用による日本語版DN-CASの変化 (2013)
  • Author(s): 川久保友紀・石井礼花・濱田純子・蔦森絵美・戸所綾子・桑原斉・金生由紀子
  • Organizer: 第54回児童青年精神医学会
  • Place of Presentation: 札幌、北海道
• [Presentation] AD/HD児ペアレントトレーニング参加中の母親の心理状態の変化過程 母親・子どもの特性および前後変化との関連についての予備的検討 (2013)
  • Author(s): 蔦森絵美、濱田純子、石井礼花、桑原斉、川久保友紀、金生由紀子
  • Organizer: 第54回児童青年精神医学会
  • Place of Presentation: 札幌、北海道
• [Presentation] Conners' Adult ADHD Rating Scale (CAARS)日本語版の開発（1）―CAARS自己報告式の信頼性と妥当性の検討― (2013)
  • Author(s): 大西将史、染木史緒、石井礼花、市川宏伸、内山敏、金澤潤一郎、神尾陽子、川久保友紀、齊藤万比古、齋藤卓弥、杉山登志郎、武田俊信、竹林淳和、田中康雄、根来秀樹、松本英夫、渡部京太、辻井正次、森則夫、中村和彦
  • Organizer: 第54回児童青年精神医学会
  • Place of Presentation: 札幌、北海道
• [Presentation] 自閉症スペクトラム障害成人の感情制御を目的とした小集団認知行動療法の効果検証 (2013)
  • Author(s): 黒田美保, 川久保友紀, 桑原斉, 金生由紀子, 神尾陽子
  • Organizer: 第54回児童青年精神医学会
  • Place of Presentation: 札幌、北海道
• [Book] これからの発達障害のアセスメント (2015)
  • Author(s): 川久保友紀
  • Total Pages: 98
  • Publisher: 金子書房
• [Book] 発達障害の理解と支援のためのアセスメント(第4章第4節 自閉症のアセスメント（２）ADOS,ADI-R他）． (2013)
  • Author(s): 川久保友紀
  • Total Pages: 198
  • Publisher: 日本文化科学社