A study of neural network alterations in autism using nonlinear neuroimaging approach
| Project/Area Number |
25461755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kanazawa University (2014-2015)
University of Fukui (2013) |
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Principal Investigator |
Takahashi Tetsuya 金沢大学, 子どものこころの発達研究センター, 准教授 (00377459)
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| Co-Investigator(Kenkyū-buntansha) |
Kawatani Masao 福井大学, 医学部付属病院, 講師 (10362047)
Ueno Kanji 福井大学, 医学部付属病院, 医員 (50600152)
Okazaki Ryoko 福井大学, 医学部付属病院, 医員 (90647778)
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| Co-Investigator(Renkei-kenkyūsha) |
Ishitobi Makoto 国立精神神経センター, 室長 (50464053)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 自閉性障害 / 神経ネットワーク / 脳波・脳磁図 / 非線形理論 / グラフ理論 / 自閉症スペクトラム障害 / 脳内神経ネットワーク障害 / 非線形複雑性理論 / マルチスケールエントロピー解析 / スモールワールドネス / 脳波 / 脳磁図 / 非線形解析 / ﾏﾙﾁｽｹｰﾙｴﾝﾄﾛﾋﾟｰ / 神経ネットワーク障害 |
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| Outline of Final Research Achievements |
Aberrant neural network lies at the heart of autism spectrum disorders (ASD). Nonlinear theory and graph theory approaches to EEG and MEG data have provided a useful framework to study functional neural networks architecture. Regarding these two theories, we aimed to characterize the neural network alterations in ASD.
Results suggested that evaluation of EEG complexity offers a useful therapeutic assessment of ASD (Okazaki et al., 2015). Additionally, enhanced brain development (MEG signal variability) (Takahashi et al., 2016) and hyper-efficiency (higher small-worldness) (Takahashi et al., Submitted) were observed in children with ASD.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism.2016
Author(s)
Kurita T, Kikuchi M, Yoshimura Y, Hiraishi H, Hasegawa C, Takahashi T, Hirosawa T, Furutani N, Higashida H, Ikeda T, Mutou K, Asada M, Minabe Y.
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Journal Title
PLoS One
Volume: 13
Issue: 4
Pages: 0153077-0153077
DOI
Related Report
Peer Reviewed / Open Access
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