Schizophrenia and oligodendrocyte; roles of hnRNPC1 and 2

• Project/Area Number: 25461756
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: University of Fukui
• Principal Investigator: Iwata Keiko 福井大学, 子どものこころの発達研究センター, 特命助教 (30415088)
• Co-Investigator(Kenkyū-buntansha): MATSUZAKI Hideo 福井大学, 子どものこころの発達研究センター, 教授 (00334970) ; MANABE Takayuki 中京学院大学, 看護学部, 教授 (90382283)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: oligodendrocyte / schizophrenia / hnRNPC / cell line / 神経科学 / 国際情報交換 / 統合失調症 / オリゴデンドロサイト / hnRNP C1/C2

Outline of Final Research Achievements

The aim of this project is elucidation of pathophysiology of schizophrenia regarding myelination abnormality. We found that the expression change of hnRNP C2 effected on the expression of a myelination gene. Our findings suggest the involvement of the molecule in myelination and the pathophysiology of schizophrenia.

Research Products

• [Int'l Joint Research] University of Campinas(Brazil)
• [Journal Article] Fluvoxamine reverses estrogen-dependent decline in voluntary activities and decreased amygdala levels of serotonin in ovariectomized rats. (2016)
  • Author(s): Ishibashi Y, Izumo N, Iwata K, Morikawa T, Kameyama T, Watanabe Y, Manabe T Matsuzaki H.
  • Journal Title: Journal of Brain Science Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia. (2015)
  • Author(s): Guest PC#, Iwata K#, Kato TA#, Steiner J, Schmitt A, Turck CW, Martins-de-Souza D. (#The first two authors contributed equally to this work.)
  • Journal Title: Front Cell Neurosci Volume: 12 Pages: 180-180
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The human oligodendrocyte proteome. (2013)
  • Author(s): Iwata K, Café-Mendes CC, Schmitt A, Steiner J, Manabe T, Matsuzaki H, Falkai P, Turck CW, Martins-de-
  • Journal Title: Proteomis Volume: 13 Issue: 23-24 Pages: 3548-3663
  • DOI: 10.1002/pmic.201300201
  • Peer Reviewed
• [Presentation] Alteration of the expression balance of hnRNP C1 and C2 changes the expression of myelination- and schizophrenia-related genes in the human oligodendrocytic cell line. (2014)
  • Author(s): Iwata K, Matsuzaki H, Manabe T, Martins-de-Souza D.
  • Organizer: 4rd Biennial Schizophrenia International Research Society Conference
  • Place of Presentation: Florence, Italy
  • Year and Date: 2014-04-05 – 2014-04-09
• [Presentation] Studying cultured astrocytes, oligodendrocytes and neurons to reveal where are the proteomic differences observed in schizophrenia brains. (2013)
  • Author(s): Martins-de-Souza D, Iwata K, Schmitt A, Falkai P, Turck C. W.
  • Organizer: 14th International Congress on Schizophrenia Research
  • Place of Presentation: Florida, USA