Association between GABA concentration in the brain of and clinical parameter of individuals with high-functioning autism

• Project/Area Number: 25461759
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: WAKUDA TOMOYASU 浜松医科大学, 医学部附属病院, 講師 (80444355)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Katsuaki 浜松医科大学, 医学部, 准教授 (00285040) ; OMATA Kei 浜松医科大学, 光尖端医学教育研究センター, 助教 (20508783) ; TAKEBAYASHI Kiyokazu 浜松医科大学, 医学部附属病院, 講師 (50397428)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 高機能自閉症 / GABA / PET画像 / 磁気共鳴スペクトル法

Outline of Final Research Achievements

The aim of the present study was to measure concentrations of GABA in the brain of　high-functioning autism by means of magnetic resonance spectroscopy (MRS) and to examine the association between GABA concentrations and clinical parameter. The Autism
Diagnostic Observation Schedule (ADOS) module 4, Autism Diagnostic Interview-Revised (ADI-R), and the Sensory Profile (SP) were used to evaluate current and childhood autism symptoms.
We have obtained the license of the use of MEGA-PRESS spectroscopy for the detection of GABA from GE in 2015. Further evaluations with more participants will be required.

Research Products

• [Journal Article] Gazefinder as a clinical supplementary tool for discriminating between autism spectrum disorder and typical development in male adolescents and adults. (2016)
  • Author(s): Fujioka T, Inohara K, Okamoto Y, Masuya Y, Ishitobi M, Saito DN, Jung M, Arai S, Matsumura Y, Fujisawa TX, Narita K, Suzuki K, Tsuchiya JK, Mori N, Katayama T, Sato M, Munesue T, Okazawa H, Tomoda A, Wada Y, Kosaka H.
  • Journal Title: Molecular Autism Volume: 7 Issue: 1 Pages: 19-19
  • DOI: 10.1186/s13229-016-0083-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome-wide Association Study of Autism Spectrum Disorder in the East Asian Populations. (2016)
  • Author(s): 2. Liu X, Shimada T, Otowa T, Wu YY, Kawamura Y, Tochigi M, Iwata Y, Umekage T, Toyota T, Maekawa M, Iwayama Y, Suzuki K, Kakiuchi C, Kuwabara H, Kano Y, Nishida H, Sugiyama T, Kato N, Chen CH, Mori N, Yamada K, Yoshikawa T, Kasai K, Tokunaga K, Sasaki T, Gau SS.
  • Journal Title: Autism Res. Volume: 9 Issue: 3 Pages: 340-9
  • DOI: 10.1002/aur.1536
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 精神疾患と脳画像 (2015)
  • Author(s): 鈴木 勝昭
  • Journal Title: 脳21 Volume: 18 Pages: 211-214
• [Journal Article] Perinatal asphyxia alters neuregulin-1 and COMT gene expression in the medial prefrontal cortex in rats (2015)
  • Author(s): Wakuda T, Iwata K, Iwata Y, Anitha A, Takahashi T, Yamada K, Vasu MM, Matsuzaki H, Suzuki K, Mori N.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 2 Pages: 149-154
  • Peer Reviewed
• [Journal Article] Serum microRNA profiles in children with autism. (2014)
  • Author(s): Mundalil Vasu M, Anitha A, Thanseem I, Suzuki K, Yamada K, Takahashi T, Wakuda T, Iwata K, Tsujii M, Sugiyama T, Mori N.
  • Journal Title: Mol Autism Volume: 5 Issue: 1 Pages: 40-40
  • DOI: 10.1186/2040-2392-5-40
  • Peer Reviewed / Open Access
• [Journal Article] Zinc finger protein 804A (ZNF804A) and verbal deficits in individuals with autism. (2014)
  • Author(s): Anitha A, Thanseem I, Nakamura K, Vasu MM, Yamada K, Ueki T, Iwayama Y, Toyota T, Tsuchiya KJ, Iwata Y, Suzuki K, Sugiyama T, Tsujii M, Yoshikawa T, Mori N.
  • Journal Title: J Psychiatry Neurosci Volume: 39 Pages: 294-303
  • Peer Reviewed
• [Journal Article] Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHMT2 and WIZ, in Japanese autism subjects. (2014)
  • Author(s): 2.Balan S, Iwayama Y, Maekawa M, Toyota T, Ohnishi T, Toyoshima M, Shimamoto C, Esaki K, Yamada K, Iwata Y, Suzuki K, Ide M, Ota M, Fukuchi S, Tsujii M, Mori N, Shinkai Y. and Yoshikawa T.
  • Journal Title: Molecular Autism Volume: 5 Issue: 1 Pages: 49-49
  • DOI: 10.1186/2040-2392-5-49
  • Peer Reviewed / Open Access
• [Journal Article] 広汎性発達障害児における感覚刺激への反応異常 日本語版Sensory Profileによる評定 (2014)
  • Author(s): 梅田亜沙子、惠藤絢香、岩永竜一郎、鈴木勝昭、辻井 正次
  • Journal Title: 小児の精神と神経 Volume: 53 Pages: 353-365
  • Peer Reviewed
• [Journal Article] 【自閉症スペクトラム障害の脳画像研究の進歩】 自閉症スペクトラム障害の脳病態の分子イメージング (総説) (2013)
  • Author(s): 鈴木勝昭
  • Journal Title: 脳21 Volume: 16 Pages: 186-192