neural and genetic basis of pathological gambling

• Project/Area Number: 25461764
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyoto University
• Principal Investigator: hazama masaaki 京都大学, 医学(系)研究科(研究院), 助教 (30360621)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 病的賭博 / ＭＲＩ / 遺伝子多型 / ドーパミン / ギャンブル障害 / MRI / 脳画像

Outline of Final Research Achievements

Twenty-nine individuals with gambling disorder (GD) and 34 age-, gender-matched healthy controls underwent genotyping for the Taq1A polymorphism and diffusion-weighted imaging. In group comparison, there was no significant difference in the fractional anisotropy (FA) between individuals with GD and healthy controls. The interaction between diagnosis and polymorphism also did not reach significance. On the other hand, individuals with minor allele carrier in the both group showed a significant FA reduction in the prefrontal region such as the genu of corpus callosum and the corona radiata than minor allele non-carrier. This result suggests that the Taq1A polymorphism might have influence on white matter integrity.

Research Products

• [Presentation] ギャンブル障害患者の島皮質をseedとした安静時脳機能結合について (2015)
  • Author(s): 鶴身孝介, 川田良作, 村尾託朗, 竹内秀暁, 竹村有由, 挾間雅章, 村井俊哉, 高橋英彦
  • Organizer: 平成27年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 神戸国際会議場（神戸市中央区）
  • Year and Date: 2015-10-12
• [Presentation] The effect of Taq1A polymorphism on the white matter integrity in gambling disorder. (2015)
  • Author(s): Ariyoshi Takemura, Masanori Isobe, Jun Miyata, Kosuke Tsurumi, Ryosaku Kawada, Naoto Yokoyama, Masaaki Hazama, Toshiya Murai, Hidehiko Takahashi
  • Organizer: International Society of Addiction Medicine(ISAM) 2015
  • Place of Presentation: Dundee, Scotland
  • Year and Date: 2015-10-05
  • Int'l Joint Research
• [Presentation] ギャンブル障害患者の安静時脳機能結合について (2015)
  • Author(s): 鶴身孝介, 川田良作, 挾間雅章, 村尾託朗, 竹内秀暁, 竹村有由, 杉原玄一, 宮田淳, 村井俊哉, 高橋英彦
  • Organizer: 第37回 日本生物学的精神医学会
  • Place of Presentation: タワーホール船堀（東京都江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] Increased functional connectivity at rest between insula and reward system in pathological gamblers (2015)
  • Author(s): Kosuke Tsurumi, Ryosaku Kawada, Naoto Yokoyama, Kimito Hirose, Makiko Yamada, Masaaki Hazama, Jun Miyata, Toshiya Murai, Hidehiko Takahashi
  • Organizer: 21th annual Meeting of theOrganization for Human Brain Mapping
  • Place of Presentation: Hawaii Convention Center, Honolulu, USA
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] ギャンブル障害における遺伝子多型と脳構造の関連について (2014)
  • Author(s): 竹村有由、磯部昌憲、宮田淳、鶴身孝介、川田良作、横山如人、挾間雅章、
  • Organizer: アルコール・薬物依存関連学会合同学術集会
  • Place of Presentation: パシフィコ横浜 会議センター
  • Year and Date: 2014-10-03 – 2014-10-04