Increase in Abeta42 production and accelerated dissociation of Abeta42 from gamma-secretase

Research Project

Project/Area Number	25461768
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Psychiatric science
Research Institution	Osaka University
Principal Investigator	Okochi Masayasu 大阪大学, 医学(系)研究科(研究院), 講師 (90335357)
Co-Investigator(Kenkyū-buntansha)	TAGAMI Shinji 大阪大学, 医学系研究科, 助教 (40362735)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	アルツハイマー病 / アミロイドβ蛋白 / γセクレターゼ / 老人斑 / 膜内蛋白分解 / 酵素と基質の解離 / Aβ / 膜内タンパク分解
Outline of Final Research Achievements	We have analyzed long Abeta binding to gamma-secretase, and found that dissociation of long Abeta from gamma-secretase is enhanced, when Abeta42 production increases.

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