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A clinicopathological study on the cognitive and motor function, prognosis, and quality of life of patients with argyrophilic grain disease

Research Project

Project/Area Number 25461771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionOkayama University

Principal Investigator

Ikdeda Chikako  岡山大学, 大学病院, 医員 (10648231)

Co-Investigator(Kenkyū-buntansha) Terada Seishi  岡山大学, 医歯薬学総合研究科, 准教授 (20332794)
Yokota Osamu  岡山大学, 医学部, 客員研究員 (60379732)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords嗜銀顆粒病 / 進行性核上性麻痺 / 皮質下諸核 / タウ / tufted astrocyte / 4リピートタウ / グレイン型認知症 / 病変分布 / リハビリ / 皮質基底核変性症 / 4リピートタウ
Outline of Final Research Achievements

Progressive supranuclear palsy (PSP) cases frequently have argyrophilic grain disease (AGD). However, the frequency of neurofibrillary tangles and tufted astrocytes in the subcortical nuclei and frontal cortex in AGD cases remains unclear. To address these issues, we examined tau-positive inclusions in these regions in 19 AGD cases, nine pathologically-confirmed PSP cases, and 20 controls. Our results suggested that the progression of AGD may be associated with the development of PSP-like tau pathologies, and a common pathological process may lie upstream of the occurrence of AGD and PSP pathology, although these diseases have been considered different. In the present study, the clinicopathological correlation between mild tau pathology in the subcortical nuclei and clinical features could not be examined, because detailed neurological data on our AGD cases were not available. Further studies will be needed.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2016 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (6 results)

  • [Journal Article] The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease2016

    • Author(s)
      Chikako Ikeda, Osamu Yokota, Shigeto Nagao, Hideki Ishizu, Etsuko Oshima, Masato Hasegawa, Yuko Okahisa, Seishi Terada, Norihito Yamada
    • Journal Title

      Brain Pathology

      Volume: 印刷中 Issue: 4 Pages: 488-505

    • DOI

      10.1111/bpa.12319

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Corticobasal degeneration initially developing motor versus non-motor symptoms: a comparative clinicopathological study2014

    • Author(s)
      Ikeda C, Yokota O, Nagao S, Ishizu H, Morisada Y, Terada S, Nakashima Y, Akiyama H, Uchitomi Y
    • Journal Title

      Psychogeriatrics

      Volume: 14 Issue: 3 Pages: 152-164

    • DOI

      10.1111/psyg.12054

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 嗜銀顆粒病における進行性核上性麻痺病理の形成と進展:免疫組織化学的・生化学的検討2014

    • Author(s)
      池田智香子,横田修,長尾茂人,石津秀樹,寺田整司,須藤浩一郎,森定ゆみ,長谷川成人,内富庸介
    • Organizer
      第33回日本認知症学会学術集会
    • Place of Presentation
      神奈川
    • Year and Date
      2014-11-30
    • Related Report
      2014 Research-status Report
  • [Presentation] 嗜銀顆粒病症例における軽度の進行性核上性麻痺病理に関する検討2014

    • Author(s)
      池田智香子,横田 修,長尾茂人,石津秀樹,寺田整司,原口 俊,須藤浩一郎,森定ゆみ、長谷川成人,内富庸介
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-06
    • Related Report
      2014 Research-status Report
  • [Presentation] 初期に行動異常と幻覚を認め,皮質基底核変性症とargyrophilic grain diseaseの病理を有した二剖検例2013

    • Author(s)
      池田智香子,横田修,武田俊彦,石津秀樹,大島悦子,岸本由紀,武田直也,長尾茂人,坂根克明,寺田整司,森定ゆみ,森定諦,内富庸介
    • Organizer
      第54回神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 晩発性精神病性障害: 神経変性疾患の頻度と重症度について2013

    • Author(s)
      長尾茂人,横田修,池田智香子,武田直也,岸本由紀,大島悦子,石津秀樹,黒田重利,森定ゆみ,須藤浩一郎,寺田整司,内富庸介
    • Organizer
      第54回神経病理学会総会学術研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 遅発性精神病性障害を呈す病理背景とその臨床スペクトラム2013

    • Author(s)
      長尾茂人,横田修,池田智香子,大島悦子,石津秀樹,黒田重利,森定ゆみ,須藤浩一郎,中島良彦,寺田整司,内富庸介
    • Organizer
      第28回老年精神学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Presentation] 精神症状で初発する皮質基底核変性症の臨床病理学的検討2013

    • Author(s)
      池田智香子,横田修,長尾茂人,大島悦子,原口俊,石津秀樹,寺田整司,井原雄悦,秋山治彦,内富庸介
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      長野
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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