| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
It is well known that patients with major depressive disorder claim appetite loss and body weight loss. In this study we tried to examine whether their gustatory or olfactory function is abnormal. Since it was revealed that all patients with informed consent have normal olfactory function, we failed to test their function by functional MRI study. Patients with panic disorder under treatment by antidepressants, however, showed very low threshold for detection and recognition of odors. None of them has experiences of panic attacks evoked by odor stimulation. We suppose that their hyperactivity in the amygdala underlies hypersensitive olfactory function.
These results suggest the possibility that olfactory function in various psychiatric or neurological disorders may give us useful information in diagnosis or treatment.
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