Investigation into the biochemical factors associated with each of 3 independent ASD symptoms.
| Project/Area Number |
25461774
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUWABARA Hitoshi 東京大学, 医学部附属病院, 准教授 (50456117)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Tsukasa 東京大学, 医学系研究科, 教授 (50235256)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ASD / コホート / 遺伝子多型 / 重症度 / 独立症状 / 自閉症スペクトラム / 自閉症 / 双生児 |
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| Outline of Final Research Achievements |
The present study investigated the association between the symptomatic severity of ASD-like behavioral tendency and the biochemical factors by a longitudinal birth-cohort study. The analysis revealed that the total score of M-CHAT at 18 months-old is significantly associated with the genotypes of single nucleotide polymorphism in brain-derived neurotrophic factor gene and variable tandem repeat number polymorphism in serotonin-transporter gene. These results indicate that genetic polymorphisms, that exacerbate vulnerability to environmental stresses, serve as the risk factor for expression of ASD-like behavioral tendency.
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Report
(4 results)
Research Products
(5 results)
