| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The present study investigated the association between the symptomatic severity of ASD-like behavioral tendency and the biochemical factors by a longitudinal birth-cohort study. The analysis revealed that the total score of M-CHAT at 18 months-old is significantly associated with the genotypes of single nucleotide polymorphism in brain-derived neurotrophic factor gene and variable tandem repeat number polymorphism in serotonin-transporter gene. These results indicate that genetic polymorphisms, that exacerbate vulnerability to environmental stresses, serve as the risk factor for expression of ASD-like behavioral tendency.
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