Neural mechanism of cognitive deficits in an animal model of schizopnrenia

• Project/Area Number: 25461775
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Fukushima Medical University
• Principal Investigator: Jodo Eiichi 福島県立医科大学, 医学部, 准教授 (50211975)
• Co-Investigator(Kenkyū-buntansha): Suzuki Yoshiaki 福島県立医科大学, 医学部, 博士研究員 (80423797)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 前頭前皮質 / 注意 / ユニット活動 / phencyclidine / 動物モデル / 統合失調症 / ユニット記録 / 脳内刺激 / ラット / 電気生理学 / 注意転換課題 / フェンサイクリジン / 統合失調症動物モデル / PET / schizophrenia / prefrontal cortex / attention-set shifting / electrophysiology / rat

Outline of Final Research Achievements

This study was designed to develop a new measuring system that can measure the function of attentional-set shifting (ASS) with recording unit-activity of neurons in healthy animals and animal models of schizophrenia. We developed an ASS testing system, which uses visual and auditory stimuli that can readily be synchronized with neuronal activity as a discriminative stimulus. Using this system, single-unit activity of the infralimbic region in the medial prefrontal cortex was recorded during performing the task. The results showed that about 27% of neurons recorded exhibited ASS-relevant changes in firing activity, which were classified into 10 different types depending on response characteristics to stimuli.

Research Products

• [Presentation] A comparison between the firing activities of rat basolateral amygdala neurons in a socially interactive situation and in a novel environment (2015)
  • Author(s): Tadahiro Kataya, Eiichi Jodo
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2015-07-29
• [Presentation] Various responses of neurons in the ventro-medial prefrontal cortex of rats during performing an attentional set-shifting task (2014)
  • Author(s): Eiichi Jodo
  • Organizer: 日本神経科学学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-12
• [Book] Neuropathology of drug addiction and substance misuse Vol. 2 (2016)
  • Author(s): Eiichi Jodo et al., edited by Victor Preedy
  • Total Pages: 1143
  • Publisher: Academic Press