Stimulation-induced responses and neuroplasticity of heteromodal neocortices in autism spectrum disorder
| Project/Area Number |
25461776
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Yokohama City University |
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Principal Investigator |
NAKAMURA Motoaki 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (50464532)
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| Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Ryuichiro 首都大学東京, 人文科学研究科, 准教授 (00585838)
ITAHASHI Takashi 昭和大学, 発達障害医療研究所, 講師 (70636943)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 経頭蓋磁気刺激法 / 前頭前野 / 神経可塑性 / 自閉症スペクトラム障害 / 作動記憶 / 誘発脳波 / 広汎性発達障害 |
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| Outline of Final Research Achievements |
We have established a methodology of the present experiment, combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG). Twenty-nine typically developed subjects and 20 subjects with autism spectrum disorder (ASD) underwent the TMS-EEG experiment. TMS-evoked EEG potentials (mainly N45 component) and cognitive function were measured over time before and after the theta burst stimulation (TBS) applied to the left prefrontal cortex. In typically developed subjects, the active TBS group showed the temporary enhancement of the N45 amplitude (10 to 50 minutes) and the working memory task (20 to 40 minutes) following the prefrontal TBS, as compared with the sham TBS group. In contrast, ASD subjects did not show any temporary changes such as the N45 enhancement or working memory improvement following the prefrontal TBS. The present findings could suggest a substantial discrepancy between the typically developed and ASD subjects in terms of the prefrontal plasticity.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Linked alterations in gray and white matter morphology in adults with high-functioning autism spectrum disorder: A multimodal brain imaging study2015
Author(s)
Itahashi T, Yamada T, Nakamura M, Watanabe H, Yamagata B, Jimbo D, Shioda S, Kuroda M, Toriizuka K, Kato N, Hashimoto R.
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Journal Title
NeuroImage: Clinical
Volume: Volume 7
Pages: 155-169
Related Report
Peer Reviewed / Open Access
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[Journal Article] Altered orbitofrontal sulcogyral patterns in adult males with high-functioning autism spectrum disorders.2014
Author(s)
Watanabe H, Nakamura M, Ohno T, Itahashi T, Tanaka E, Ohta H, Yamada T, Kanai C, Iwanami A, Kato N, Hashimoto R.
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Journal Title
Soc Cogn Affect Neurosci
Volume: Apr;9(4)
Pages: 520-528
Related Report
Peer Reviewed / Open Access
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[Journal Article] Altered orbitofrontal sulcogyral patterns in adult males with high-functioning autism spectrum disorders.2014
Author(s)
Watanabe H, Nakamura M, Ohno T, Itahashi T, Tanaka E, Ohta H, Yamada T, Kanai C, Iwanami A, Kato N, Hashimoto R.
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Journal Title
Social cognitive and affective neuroscience
Volume: 9(4)
Pages: 520-8
Related Report
Peer Reviewed
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