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Widespread abnormalities in white matter integrity and their relationship with duration of illness in temporal lobe epilepsy

Research Project

Project/Area Number 25461779
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionWakayama Medical University

Principal Investigator

Tsuji Tomikimi  和歌山県立医科大学, 医学部, 非常勤講師 (10347586)

Co-Investigator(Kenkyū-buntansha) 小瀬 朝海  和歌山県立医科大学, 医学部, 助教 (10405425)
高橋 隼  和歌山県立医科大学, 医学部, 講師 (10508021)
金桶 吉起  和歌山県立医科大学, 医学部, 教授 (20280589)
西林 宏起  和歌山県立医科大学, 医学部, 講師 (30372866)
篠崎 和弘  和歌山県立医科大学, 医学部, 教授 (40215984)
鵜飼 聡  和歌山県立医科大学, 医学部, 准教授 (80324763)
山本 眞弘  和歌山県立医科大学, 医学部, 助教 (80423937)
坂本 友香  和歌山県立医科大学, 医学部, 助教 (90423938)
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords側頭葉てんかん / 拡散テンソル / TBSS / 罹病期間 / てんかん / diffusion tensor imaging / QOL
Outline of Final Research Achievements

We examined abnormalities in whole-brain white matter integrity and their relationship with duration of illness in patients with temporal lobe epilepsy (TLE).
In the TLE group, compared with the healthy control group, FA was reduced and MD and RD were increased, not only in the limbic and temporal lobe regions and their directly connecting regions in both hemispheres, but also in remote white matter regions. Duration of illness showed a significant negative correlation with mean whole-brain FA and a significant positive correlation with both mean whole-brain MD and RD. Brain regions showing correlation between disease duration and DTI metrics also extended to the limbic and its connecting regions and to remote white matter regions. The results of this study suggest that widespread abnormalities in white matter integrity in patients with TLE and progression of neural damage are associated with long-term disease.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Levetiracetam2015

    • Author(s)
      辻 富基美
    • Journal Title

      精神科治療学

      Volume: 30 Pages: 1021-1026

    • Related Report
      2015 Research-status Report
  • [Journal Article] 当科に入院したてんかん患者の検討2015

    • Author(s)
      喜多 彬, 辻 富基美, 鵜飼 聡, 篠崎 和弘
    • Journal Title

      大阪てんかん研究会雑誌

      Volume: 33 Pages: 19-22

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] rTMS/NIRSの同時測定による上側頭回-前頭葉の脳部位間結合性の評価2015

    • Author(s)
      Author:高橋 隼, 鵜飼 聡, 喜多 彬, 山田 信一, 正山 勝, 辻 富基美, 篠崎 和弘
    • Journal Title

      日本薬物脳波学会雑誌

      Volume: 43 Pages: 23-28

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] てんかんにパニック障害が合併した5症例2014

    • Author(s)
      辻 富基美
    • Journal Title

      精神科

      Volume: 25 Pages: 25-31

    • Related Report
      2014 Research-status Report
  • [Presentation] 側頭葉てんかんにおける脳梁でのTSA, TBSSによる拡散テンソル画像の検討2017

    • Author(s)
      津田久美、辻富基美、石田卓也、高橋隼、山田信一、鵜飼聡、寺田正樹、篠崎和弘
    • Organizer
      第46回大阪てんかん研究会
    • Place of Presentation
      大阪
    • Related Report
      2016 Annual Research Report
  • [Presentation] 側頭葉てんかんにおけるTract-Based Spatial Statistics (TBSS) による拡散テンソル画像の検討2016

    • Author(s)
      津田久美、辻富基美、石田卓也、高橋隼、山田信一、鵜飼聡、寺田正樹、篠崎和弘
    • Organizer
      第20回日本精神保健・予防学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] 側頭葉てんかんにおける脳梁での拡散テンソル画像の検討2015

    • Author(s)
      津田久美,辻富基美,山田信一,喜多 彬,高橋 隼,鵜飼 聡,寺田正樹,篠崎和弘
    • Organizer
      第49回日本てんかん学会
    • Place of Presentation
      長崎市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 側頭葉てんかんにおけるTract-Specific Analysisによる拡散テンソル画像脳梁のFA値と罹病期間の検討2015

    • Author(s)
      辻富基美,津田久美,山田信一,喜多 彬,高橋 隼,鵜飼 聡,寺田正樹,篠崎和弘
    • Organizer
      第17回脳機能マッピング学会
    • Place of Presentation
      大阪市
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
  • [Presentation] 側頭葉てんかんにおけるてんかん性精神病の 拡散テンソル画像の検討2014

    • Author(s)
      辻 富基美、津田久美、山田信一、石田卓也、喜多 彬、高橋 隼、鵜飼 聡、篠崎和弘
    • Organizer
      第48回日本てんかん学会
    • Place of Presentation
      東京都
    • Year and Date
      2014-10-02 – 2014-10-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 前頭葉てんかん、単純部分発作重積状態を呈した1症例2014

    • Author(s)
      喜多 彬、辻 富基美、篠崎和弘
    • Organizer
      第10回近畿てんかん地方会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-08-04
    • Related Report
      2014 Research-status Report
  • [Presentation] てんかんに心因性非てんかん性発作を合併した症例の長期経過2014

    • Author(s)
      辻 富基美、篠崎和弘
    • Organizer
      第115回近畿精神神経学会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-07-26
    • Related Report
      2014 Research-status Report
  • [Presentation] てんかん患者の精神症状とQOL

    • Author(s)
      辻富基美
    • Organizer
      第18回日本神経精神医学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 今日の診断のために ガイドラインガイライン診療2017 てんかん2016

    • Author(s)
      辻 富基美
    • Total Pages
      4
    • Publisher
      日経メディカル開発
    • Related Report
      2016 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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