| Project/Area Number |
25461782
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Mimura Masaru 慶応義塾大学, 医学部, 教授 (00190728)
Torii Katsuyoshi 名古屋市立大学, 医学研究科, 研究員 (20551287)
Miyata Jun 京都大学, 医学研究科, 講師 (90549099)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 認知症 / 精神症状 / テンソル画像 / FA値 / 縦断的変化 / 脳画像 / MRI / 脳形態画像 / 拡散テンソル画像 |
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| Outline of Final Research Achievements |
The neural substrate underlying the longitudinal changes of neuropsychiatric symptoms in Alzheimer’s disease (AD) demetnia is unclear. In AD, we examined the longitudinal changes of white matter (WM) integrity using a diffusion tensor imaging (DTI) during a 2-year period in AD patients who did or who did not develop delusions. Compared with the baseline, both groups in AD have shown that the fractional antisotropy (FA) values have significantly reduced in both splenium of the corpus callosum, and bilateral temporal lobes after two years. On contrast, the FA values in the genu of the corpus callosum, bilateral frontal lobes have significantly reduced in only one group with the AD patients who developed delusions during a 2-year period. Abnormalities in WM integrity involving several fibers associated with the frontal lobe may be crucial to the longitudinal changes of delusions in AD patients.
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