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Utility of FDG-PET for diagnosis of preclinical Alzheimer's disease

Research Project

Project/Area Number 25461783
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKeio University

Principal Investigator

Tabuchi Hajime  慶應義塾大学, 医学部, 講師 (10286578)

Co-Investigator(Renkei-kenkyūsha) Ito Daisuke  慶應義塾大学, 医学部, 講師 (80286450)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords人間ドック / FDG-PET / アルツハイマー病 / 発症前診断 / 病名告知 / 軽度認知障害 / レビー小体型認知症
Outline of Final Research Achievements

Of those who accepted cancer screening (early detection of cancer by FDG-PET) at Keio university hospital preventive medicine center, 35 individuals were taken an additional image of brain FDG-PET, and underwent brain MRI, cognitive testing, and psychological tests. In 35 participants, four subjects had positive findings on brain FDG-PET, which suggested preclinical Alzheimer’s disease. However, there were no abnormal findings on brain MRI and no declines in performance on neuropsychological tests in them. Also, they didn’t complain subjective cognitive impairments. After telling the results of FDG-PET to participants, the mood and anxiety scores changed for the worse on one FDG-PET positive subject.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (25 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Diagnostic accuracy of neuropsychological tests for classification of dementia2016

    • Author(s)
      4. Yagi T, Ito D, Sugiyama D, Iwasawa S, Tabuchi H, Konishi M, Araki M, Saitoh N, Mimura M, Suzuki N
    • Journal Title

      Neurology Asia

      Volume: 21 Pages: 47-54

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経認知障害 認知症に於ける疾患概念形成を知ることの重要性2016

    • Author(s)
      沖村宰, 田渕肇, 三村將
    • Journal Title

      臨床精神医学

      Volume: 45 Pages: 215-221

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 認知症患者はどの程度の病識を持てるか2015

    • Author(s)
      船木桂、田渕肇
    • Journal Title

      精神科治療学

      Volume: 30 Pages: 1207-1212

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 神経認知障害群(NCD)の神経認知領域;その概念と評価をめぐる現状と課題 DSM-5における神経認知障害(NCD)の神経認知領域―その背景と意義2015

    • Author(s)
      田渕肇、沖村宰、三村將
    • Journal Title

      老年精神医学雑誌

      Volume: 26 Pages: 237-241

    • Related Report
      2014 Research-status Report
  • [Journal Article] 米国DSM-5における精神疾患、神経認知症群―アルツハイマー病による認知症または軽度認知障害を中心に2014

    • Author(s)
      沖村宰、田渕肇、三村將
    • Journal Title

      臨床精神医学

      Volume: 43

    • Related Report
      2014 Research-status Report
  • [Journal Article] アルツハイマー病による認知症または軽度認知障害2014

    • Author(s)
      沖村宰、田渕肇、三村將
    • Journal Title

      老年精神医学雑誌

      Volume: 25 Pages: 858-861

    • Related Report
      2014 Research-status Report
  • [Journal Article] Reverse Fox test for detecting visuospatial dysfunction corresponding to parietal hypoperfusion in mild Alzheimer’s disease.2014

    • Author(s)
      Tabuchi H, Konishi M, Saito N, Kato M, Mimura M.
    • Journal Title

      Am J Alzheimers Dis Other Demen.

      Volume: 29 Issue: 2 Pages: 177-182

    • DOI

      10.1177/1533317513511291

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced visual artistry and high accuracy of visual numerosity representation after left prefrontal damage2014

    • Author(s)
      Keisuke Takahata, Fumie Saito, Taro Muramatsu, Makiko Yamada, Joichiro Shirahase, Hajime Tabuchi1, Tetsuya Suhara, Masaru Mimura, Motoichiro Kato
    • Journal Title

      Neuropsychologia

      Volume: 57 Pages: 28-49

    • DOI

      10.1016/j.neuropsychologia.2014.02.022

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] よくみられる神経疾患 認知症に対する対応2013

    • Author(s)
      田渕肇
    • Journal Title

      日本医師会雑誌

      Volume: 142

    • Related Report
      2013 Research-status Report
  • [Presentation] Female Specific intergenerational transmission patterns of the human corticolimbic cuicuitry2016

    • Author(s)
      Yamagata B, Tabuchi H, Funaki K, Mimura M, Hoeft
    • Organizer
      The 27th Annual Meeting of the American Neuropsychiatric Association
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-03-16
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] てんかん性健忘2015

    • Author(s)
      田渕肇
    • Organizer
      第39回日本高次脳機能障害学会学術総会
    • Place of Presentation
      ベルサール渋谷ファースト(東京都渋谷区)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 顕著な視覚構成障害と漢字失書を呈した若年性アルツハイマー病疑いの1例2015

    • Author(s)
      山縣文,小西海香,斉藤菜穂,田渕肇,三村將
    • Organizer
      第39回日本高次脳機能障害学会学術総会
    • Place of Presentation
      ベルサール渋谷ファースト(東京都渋谷区)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] 顕著な漢字失書を呈したアルツハイマー病疑いの1例2015

    • Author(s)
      堀込俊郎, 小西海香,斉藤菜穂,田渕肇,三村將
    • Organizer
      第39回日本高次脳機能障害学会学術総会
    • Place of Presentation
      ベルサール渋谷ファースト(東京都渋谷区)
    • Year and Date
      2015-12-10
    • Related Report
      2015 Annual Research Report
  • [Presentation] Florbetabenを用いたアミロイドイメージングの検討2015

    • Author(s)
      61. 馬島恭子,緒方雄史,長田高志,田渕肇,亀山征史,山縣文、三村將,鈴木則宏,村上康二
    • Organizer
      第34回日本認知症学会学術総会
    • Place of Presentation
      リンクステーション青森(青森県青森市)
    • Year and Date
      2015-10-02
    • Related Report
      2015 Annual Research Report
  • [Presentation] Assessment of neuropsychological features in mild dementia with Lewy bodies2015

    • Author(s)
      1. Tabuchi H, Konishi M, Ito D, Yamagata B, Oka M, Mimura M
    • Organizer
      The 12th international conference of Alzheimer’s & Parkinson’s diseases
    • Place of Presentation
      Nice, France
    • Year and Date
      2015-03-18 – 2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] False recognition memory in Rey auditory-verbal learning test for mild cognitive impairment2015

    • Author(s)
      2. Konishi M, Tabuchi H, Yamagata B, Ito D, Mimura M
    • Organizer
      The 12th international conference of Alzheimer’s & Parkinson’s diseases
    • Place of Presentation
      Nice, France
    • Year and Date
      2015-03-18 – 2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 認知症診断における各種神経心理学的検査の有効性の比較検討2014

    • Author(s)
      久住呂友紀、伊東大介、八木拓也、田渕肇、杉山大典、三村將、鈴木則宏
    • Organizer
      第33回日本認知症学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-29 – 2014-12-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Utility of neuropsychological battery for discerning Dementia with Lewy bodies from Alzheimer’s disease2014

    • Author(s)
      3. Tabuchi H, Konishi M, Ito D, Yamagata B, Oka M, Mimura M
    • Organizer
      Alzheimer’s Association International Conference
    • Place of Presentation
      Kopenhagen, Denmark
    • Year and Date
      2014-07-12 – 2014-07-17
    • Related Report
      2014 Research-status Report
  • [Presentation] 人間ドック受診者を対象とした脳FDG-PET検査と結果告知が及ぼす心理変化の検討

    • Author(s)
      伊達悠岳、伊東大介、田渕肇、緒方雄史、亀山征史、荒木眞知子、村上康二、三村將、鈴木則宏
    • Organizer
      第32回日本認知症学会学術集会
    • Place of Presentation
      キッセイ文化ホール(長野県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Visual delayed recall as a predictor of conversion to Alzheimer’s disease in patients with amnesic mild cognitive impairment.

    • Author(s)
      Tabuchi H, Konishi M, Kato M, Mimura M
    • Organizer
      Alzheimer’s Association International Conference 2013
    • Place of Presentation
      ボストン(米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] The disruption of ventral striatum and amygdala activity to financial cues in never-medicated Parkinson’s disease patients.

    • Author(s)
      Takahashi K, Iwashita Y, Akine Y, Tabuchi H, Suzuki N, Kato M
    • Organizer
      21st World Congress of Neurology
    • Place of Presentation
      ウィーン(オーストリア)
    • Related Report
      2013 Research-status Report
  • [Presentation] Neuropsychological predictors of conversion to Alzheimer’s disease in patients with mild cognitive impairment

    • Author(s)
      Tabuchi H, Konishi M, Ito D, Saito N, Kato M, Mimura M.
    • Organizer
      American Association for Geriatric Psychiatry's 2014 Annual Meeting
    • Place of Presentation
      オーランド(米国)
    • Related Report
      2013 Research-status Report
  • [Presentation] 前頭葉機能検査における健常日本人データの検討-WCST(慶應版)、語想起、修正ストループ課題

    • Author(s)
      小西海香、斉藤文恵、寺澤悠里、梅田聡、福永篤志、田渕肇、三村將、加藤元一郎、鹿島晴雄
    • Organizer
      第37回日本高次脳機能障害学会学術総会
    • Place of Presentation
      島根県民会館(島根県)
    • Related Report
      2013 Research-status Report
  • [Book] 精神・心理機能評価ハンドブック2015

    • Author(s)
      田渕肇(分担執筆)、山内俊雄、鹿島晴雄(編)
    • Total Pages
      511
    • Publisher
      中山書店
    • Related Report
      2015 Annual Research Report
  • [Book] 知能の衰え、脳とこころのプライマリーケア22013

    • Author(s)
      田渕肇、鹿島晴雄
    • Total Pages
      10
    • Publisher
      シナジー
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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