Impact of Maternal Trauma History for Mind and body of Children: Gene Environment Interaction and Mental Health

• Project/Area Number: 25461786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: Miyako Shirakawa 東京女子医科大学, 医学部, 非常勤講師 (60536093)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 心的外傷 / 子ども虐待 / ドメスティックバイオレンス / 環境遺伝子相互作用 / メチレーション / 世代間伝達 / 遺伝子環境相互作用 / 産後うつ病 / オキシトシン / 外傷後ストレス障害 / アタッチメント / 母子相互作用 / トラウマ / うつ病 / 母体内環境 / 発達障害 / エピジェネシス

Outline of Final Research Achievements

We have prepared to perform a clinical study who use the women's shelter to support delivery and the hospitals and clinics of Obstetrics and Gynecology in Suginami Ward. We did our best, but it did not lead to conduct actual clinical research. We continue support to pregnant women and the mother-child dyads after birth,and also will conduct meta-analysis and making guidelines in this area, while waiting for the new opportunities to continue this study.

Research Products

• [Journal Article] Prenatal pyrethroid insecticide exposure and thyroid hormone levels and birth sizes of neonates. (2014)
  • Author(s): Zhang J, Yoshinaga J, Hisada A, Shiraishi H, Shimodaira K, Okai T, Koyama M, Watanabe N, Suzuki E, Shirakawa M, Noda Y, Komine Y, Ariki N, Kato N
  • Journal Title: The Science of the total environment Volume: Aug 1 Pages: 275-279
  • DOI: 10.1016/j.scitotenv.2014.04.104
• [Journal Article] Hypnosis for induction of labour. (2014)
  • Author(s): Nishi D, Shirakawa MN, Ota E, Hanada N, Mori R
  • Journal Title: The Cochrane database of systematic reviews Volume: Aug 14;8 Issue: 8
  • DOI: 10.1002/14651858.cd010852.pub2
  • Peer Reviewed / Open Access
• [Journal Article] Associations between Levels of Hydroxylated PCBs and PCBs in Serum of Pregnant Women and Blood Thyroid Hormone Levels and Body Size of Neonates. (2014)
  • Author(s): Hisada A., Shimodaira K., Okai T., Watanabe K., Takemori H., Takasuga T., Koyama M., Watanabe N., Suzuki E., Shirakawa M., Noda Y., Komine Y., Ariki N., Kato N. and Yoshinaga J.
  • Journal Title: International Journal of Hygiene and Environmental Health (2014) Volume: 217 Issue: 4-5 Pages: 546-553
  • DOI: 10.1016/j.ijheh.2013.10.004
  • Peer Reviewed
• [Journal Article] トラウマという視点から見た精神科臨床 トラウマから見た気分変動 (2014)
  • Author(s): 白川美也子、鈴木太
  • Journal Title: 精神科治療学 Volume: 29(5) Pages: 583-592