The dopamine transporter PET study clarify the mechanism of delusion and develop the objective evaluation method for delusion.
| Project/Area Number |
25461788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
Tateno Amane 日本医科大学, 医学部, 准教授 (50297917)
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| Co-Investigator(Kenkyū-buntansha) |
OKUBO YOSHIRO 日本医科大学, 医学研究科, 教授 (20213663)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 妄想性障害 / ドパミントランスポーター / 統合失調症 / 老年期精神障害 / ポジトロンエミッショントモグラフィー / ドーパミントランスポーター |
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| Outline of Final Research Achievements |
The role of dopamine transporter (DAT) function in the delusion and hallucination was examined by DAT positron emission tomography (PET). Seventeen geriatric patients with delusional disorder, 8 geriatric patients with schizophrenia, 12 geriatric healthy subjects, 2 young patients with delusional disorder, 6 young patients with schizophrenia and 9 young healthy controls were participated. DAT binding potential (BP) was examined by DAT-PET to compare the DAT function of each groups. Compared to geriatric healthy controls, geriatric patients with delusional disorder showed significantly lower DAT-BP. These results indicated the possibility that the decreased DAT function takes part in the mechanism of delusional disorder in old age period.
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Report
(4 results)
Research Products
(7 results)
