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A role of hypothalamic CRF on the progression of anorexia nervosa

Research Project

Project/Area Number 25461789
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionNippon Medical School

Principal Investigator

Mano Asuka  日本医科大学, 医学部, 講師 (50343588)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords神経性食欲不振症 / 視床下部 / 摂食障害 / ストレス / 過活動 / CRF / 摂食抑制 / 室傍核 / 摂食行動
Outline of Final Research Achievements

Anorexia nervosa is a severe life-threatening eating disorder characterized by self-starvation, hyper activity. Exogenous corticotropin-releasing factor (CRF) causes behavioral changes including decreased feeding and increased activity. These behavioral changes are also seen in anorexia nervosa. However, the role of hypothalamic CRF in the progression of anorexia nervosa has not been investigated fully. We examined whether the activation of hypothalamic CRF is caused in a rat of activity-based anorexia, they are given access to a running-wheel in combination with food restriction, they will be hyperactive and decrease their food intake. In ABA model rats, neuronal activity of CRF was potentiated and plasma corticosterone levels were elevated. These results indicate that hyper secretion of CRF from hypothalamus may partially induced feeding impairment or hyper activity of activity-based anorexia.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (2 results)

All 2016 Other

All Presentation (2 results)

  • [Presentation] 過活動性拒食症モデル動物におけるCRFの機能異常の解明2016

    • Author(s)
      眞野あすか
    • Organizer
      第89回日本内分泌学会学術総会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2016-04-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分界条床核におけるCRF1型受容体の局在について

    • Author(s)
      眞野あすか
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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