| Project/Area Number |
25461791
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
牛田 享宏 愛知医科大学, 医学部, 教授 (60304680)
新井 健一 愛知医科大学, 医学部, 准教授 (50380316)
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| Co-Investigator(Renkei-kenkyūsha) |
INUI Kouji 生理学研究所, 統合生理研究系, 准教授 (70262996)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 疼痛 / 生理学的指標 / 聴覚誘発反応 / 痛覚誘発反応 / 機能性障害 / 治療効果判定 / 身体症状症 / 侵害受容誘発反応 / 治療効果の可視化 / 疼痛性障害 / 治療反応性 |
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| Outline of Final Research Achievements |
Pain is a purely subjective experience and objective measurement is difficult. Thus, physiological indicators that can be quantified are important. In this project, we investigated the significance of convenient auditory and nociceptive stimulation and evoked cerebral responses. Firstly, it was shown that the P50 component reflects sensory memory, and the possibility that the change-related N1 / P2 component is related to the LDAEP was pointed out. Next, we developed the method to stimulate separately nociceptive Aδand Aβ fibers at the same site. By using this method, it was possible to evaluate the pain and the therapeutic effect functionally in pain-related diseases. Furthermore, we also examined psychological evaluation of somatic symptom disorder.
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