| Project/Area Number |
25461792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJII Noa 近畿大学, 医学部, 准教授 (90460914)
KIRIME Eiji 近畿大学, 医学部, 講師 (80368307)
YANAGI Masaya 近畿大学, 医学部, 講師 (10418775)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
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| Keywords | depression / bipolar disorder / suicide / lithium / NIRS |
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| Outline of Final Research Achievements |
We investigated the factors associated with lithium responsiveness and suicidality in mood disorders (bipolar disorder, depression) by brain function evaluated by the near-infrared spectroscopy and various clinical data.
The small number of cases with lithium responsiveness do not reach the statistical significance. On the other hand, we obtained significant results about suicidality as follows. 1) Discrepancies between self- and observer-rated depression severities are associated with vulnerability to suicide in patients with major depressive disorder, and prefrontal cortex activation is associated with these discrepancies. 2) Right temporal activation differs between melancholia and nonmelancholic depression. 3) Patients with bipolar disorders have persistent hypofunction of the frontotemporal cortical regions and the hemodynamic response in the left temporal regions is associated with symptom severity.
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