Development of non-invasive chronic stress biomarker for children
| Project/Area Number |
25461793
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 唾液中マーカー / 心理評価尺度 / 児童精神 / 小児心身症 / うつ病 |
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| Outline of Final Research Achievements |
Little is known about salivary chronic stress biomarker for children with psychosomatic symptoms.We planned a cross sectional,case-control study. Salivary cortisol and IgA were measured 5 times a day (0700h,0730h,1200h,1700h,2200h).Clinical participants, aged between 7 to 17 years, were recruited in pediatric psychosomatic medical clinic (case group). Control group were healthy children. Participants also replied psychological questionnaires. (Children’s Depression Inventory [CDI]).
This study comprised 6 case and 22 control group.All case participants complained difficulty awakening, and reduced school activities.We found that the IgA level at the time of wake-up in clinical group is significantly lower than that in control group. Moreover, we found significant negative correlation between 0700h IgA and CDI score for only clinical group, but not for control group (spearman γ=-0.86, p=0.03). Feasibility of chronic stress biomarker was indicated especially for morning salivary IgA.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Effective VCR/DEX pulse maintenance therapy in the KYCCSG ALL-02 protocol for pediatric acute lymphoblastic leukemia.2016
Author(s)
Okamoto Y, Koga Y, Inagaki J, Ozono S, Ueda K, Shimoura M, Itonaga N, Shinkoda Y, Moritake H, Nomura Y, Nakayama H, Hotta N, Hidaka Y, Shimonodan H, Suga N, Tanabe T, Nakashima K, Fukano R, Kawano Y
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Journal Title
Int J Hematol
Volume: 103
Issue: 2
Pages: 202-209
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Altered SPECT (123)I-iomazenil Binding in the Cingulate Cortex of Children with Anorexia Nervosa.2016
Author(s)
Nagamitsu S, Sakurai R, Matsuoka M, Chiba H, Ozono S, Tanigawa H, Yamashita Y, Kaida H, Ishibashi M, Kakuma T, Croarkin PE, Matsuishi T.
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Journal Title
Front Psychiatry
Volume: -
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] General Health Status and Late Effects Among Adolescent and Young Adult Survivors of Childhood Cancer in Japan.2014
Author(s)
1.Ozono S, Ishida Y, Honda M, Okamura J, Asami K, Maeda N, Sakamoto N, Inada H, Iwai T, Kamibeppu K, Kakee N, Horibe K.
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Journal Title
Jpn J Clin Oncol.
Volume: 44
Issue: 10
Pages: 932-940
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Infantile neuroblastoma of the urinary bladder detected by hematuria.2013
Author(s)
Kojima S, Yagi M, Asagiri K, Fukahori S, Tanaka Y, Ishii S, Saikusa N, Koga Y, Yoshida M, Masui D, Komatsuzaki N, Nakagawa S, Ozono S, Tanikawa K.
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Journal Title
Pediatric Surgery International
Volume: 29
Issue: 7
Pages: 753-757
DOI
Related Report
Peer Reviewed
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[Journal Article] 小児がん経験者のための長期フォローアップ手帳に関するアンケート調査2013
Author(s)
石田也寸志, 有瀧健太郎, 浅見恵子, 大園秀一, 前田美穂, 山口悦子[中上], 堀部敬三, 加藤俊一, 藤本純一郎, 黒田達夫, 日本小児白血病リンパ腫研究グループ長期フォローアップ委員会．
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Journal Title
日本小児血液・がん学会雑誌
Volume: 50
Pages: 220-226
Related Report
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