| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Little is known about salivary chronic stress biomarker for children with psychosomatic symptoms.We planned a cross sectional,case-control study. Salivary cortisol and IgA were measured 5 times a day (0700h,0730h,1200h,1700h,2200h).Clinical participants, aged between 7 to 17 years, were recruited in pediatric psychosomatic medical clinic (case group). Control group were healthy children. Participants also replied psychological questionnaires. (Children’s Depression Inventory [CDI]).
This study comprised 6 case and 22 control group.All case participants complained difficulty awakening, and reduced school activities.We found that the IgA level at the time of wake-up in clinical group is significantly lower than that in control group. Moreover, we found significant negative correlation between 0700h IgA and CDI score for only clinical group, but not for control group (spearman γ=-0.86, p=0.03). Feasibility of chronic stress biomarker was indicated especially for morning salivary IgA.
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