Development of arterial spin labeling MRI for female pelvic organs

• Project/Area Number: 25461806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Fukui
• Principal Investigator: KOSAKA NOBUYUKI 福井大学, 医学部, 助教 (60397247)
• Co-Investigator(Kenkyū-buntansha): KIMURA Hirohiko 福井大学, 医学部, 教授 (10242596) ; KUROKAWA Tetsuji 福井大学, 医学部, 准教授 (60334835) ; FUJIWARA Yasuhiro 熊本大学, 大学院生命科学研究部(保), 講師 (90422675) ; KANAMOTO Masayuki 福井大学, 医学部附属病院, 診療放射線技師 (60730728)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MRI / 子宮 / 腎臓 / 灌流画像 / 放射線 / Arterial spin labeling / 卵巣

Outline of Final Research Achievements

In this project, we developed non-contrast enhanced perfusion MRI method (arterial spin labeling method: ASL-MRI) for abdominal organs. The tissue perfusions in kidneys measured with this ASL-MRI were validated by comparing nuclear imaging methods. Furthermore, we applied this method to placental polyps in uterus, and successfully depicted their tissue perfusions and therapeutic responses visually and semi-quantitatively. Although further technical development may be needed for more stable image acquisitions, this ASL-MRI method has clinical potential for non-invasive assessment of tissue perfusion in uterus and other abdominal organs.

Research Products

• [Journal Article] Arterial Transit Time-corrected Renal Blood Flow Measurement with Pulsed Continuous Arterial Spin Labeling MR Imaging (2017)
  • Author(s): Kazuhiro Shimizu, Nobuyuki Kosaka, Yasuhiro Fujiwara, Tsuyoshi Matsuda, Tatsuya Yamamoto, Tatsuro Tsuchida, Katsuki Tsuchiyama, Nobuyuki Oyama, Hirohiko Kimura
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 1 Pages: 38-44
  • DOI: 10.2463/mrms.mp.2015-0117
  • NAID: 130005286868
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Evaluation of retained products of conception by arterial spin labeling-MRI: Clinical feasibility and initial results (2016)
  • Author(s): Nobuyuki Kosaka, Yasuhiro Fujiwara, Masayuki Kanamoto, Tsuyoshi Matsuda, Tatsuya Yamamoto, Kazuhiro Shimizu, Kanako Ota, Yoshio Yoshida, Tetsuji Kurokawa , Hirohiko Kimura.
  • Organizer: ISMRM 24th Annual Meeting & Exhibition
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Arterial spin labeling MRIを用いた遺残胎盤/胎盤ポリープの血流評価 (2015)
  • Author(s): 小坂信之、清水一浩、黒川哲司、藤原康博、松田豪、金本雅行、山元龍哉、太田加奈子、吉田好雄、木村浩彦
  • Organizer: 第43回日本磁気共鳴医学会大会
  • Place of Presentation: 東京、日本
  • Year and Date: 2015-09-10
• [Presentation] Pulsed-continuous arterial spin labeling MRI with multiple post-labeling delay in renal cell carcinoma: clinical feasibility and initial results of a comparative study with parametric dynamic contrast-enhanced MRI. (2014)
  • Author(s): Kosaka N, Tsuchiyama K, Shimizu K, Fujiwara Y, Matsuda T, Yamamoto T, Tsuchida T, Oyama N, Kimura H.
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: Milan, Italy,
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Arterial transit time-corrected renal blood flow measurement by pulsed continuous arterial spin labeling MRI: a feasibility and validation study in healthy volunteers. (2014)
  • Author(s): Shimizu K, Kosaka N, Fujiwara Y, Matsuda T, Yamamoto T, Tsuchida T, Tsuchiyama K, Oyama N, Kimura H.
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2014
  • Place of Presentation: Milan, Italy,
  • Year and Date: 2014-05-10 – 2014-05-16