Establishing CT assessment of myocardial delayed enhancement and extracellular volume fraction with dual-source CT

• Project/Area Number: 25461812
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: KITAGAWA KAKUYA 三重大学, 医学部附属病院, 講師 (50378353)
• Co-Investigator(Kenkyū-buntansha): ISHIDA MASAKI 三重大学, 医学部附属病院, 助教 (10456741) ; NAKAYAMA RYOHEI 立命館大学, 理工学部, 准教授 (20402688) ; SAKUMA HAJIME 三重大学, 医学研究科, 教授 (60205797)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: CT / 心臓 / 細胞外液分画 / 心筋線維化 / 心筋細胞外液分画

Outline of Final Research Achievements

We have developed a CT acquisition/reconstruction scheme for improved visualization of myocardial CT delayed enhancement that can also be used for the assessment of myocardial extracellular volume (ECV). ECV obtained with the proposed method demonstrated good reproducibility for all myocardial segments and demonstrated good correlation with ECV derived by MR T1 mapping. Furthermore, significant positive relationship was observed between age and ECV in patients without clinical coronary artery disease. We also developed a dictionary-based super-resolution technique to reduce radiation exposure and a software platform that can display voxel-based ECV map.

Research Products

• [Journal Article] Estimation of myocardial extracellular volume fraction with cardiac CT in subjects without clinical coronary artery disease: A feasibility study. (2016)
  • Author(s): Kurita Y, Kitagawa K, Kurobe Y, Nakamori S, Nakajima H, Dohi K, Ito M, Sakuma H.
  • Journal Title: J Cardiovasc Comput Tomogr. Volume: 10 Issue: 3 Pages: 1-5
  • DOI: 10.1016/j.jcct.2016.02.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Data on correlation between CT-derived and MRI-derived myocardial extracellular volume (2016)
  • Author(s): Kurita Y, Kitagawa K, Kurobe Y, Nakamori S, Nakajima H, Dohi K, Ito M, Sakuma H.
  • Journal Title: Data in Brief Volume: 7 Pages: 1045-1047
  • DOI: 10.1016/j.dib.2016.03.073
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Myocardial delayed enhancement with dual-source CT: advantages of targeted spatial frequency filtration and image averaging over half-scan reconstruction. (2014)
  • Author(s): Kurobe Y, Kitagawa K, Ito T, Kurita Y, Shiraishi Y, Nakamori S, Nakajima H, Nagata M, Ishida M, Dohi K, Ito M, Sakuma H.
  • Journal Title: J Cardiovasc Comput Tomogr Volume: 8 Issue: 4 Pages: 289-298
  • DOI: 10.1016/j.jcct.2014.06.004
  • Peer Reviewed
• [Presentation] Enhancing morphology by function Dynamic MPI the Mie Experience (2015)
  • Author(s): Kitagawa K
  • Organizer: SOMATOM World Summit
  • Place of Presentation: Munich, Germany
  • Year and Date: 2015-07-08
  • Invited
• [Presentation] Myocardial perfusion imaging in clinical routine: ready for prime time? (2015)
  • Author(s): Kitagawa K
  • Organizer: ECR2015
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-03-04 – 2015-03-08
  • Invited
• [Presentation] Step-by-step Guide to Myocardial Extracellular Volume Measurement Using CT (2014)
  • Author(s): Kurita Y, Kitagawa K, Uno, M, et al.
  • Organizer: RSNA2014
  • Place of Presentation: Chicago, IL, USA
  • Year and Date: 2014-11-29 – 2014-12-05
• [Presentation] The feasibility of super-resolution technique for radiation dose reduction of delayed enhancement CT with targeted spatial frequency filtration (2014)
  • Author(s): Kanii Y, Kitagawa K, Nakayama R, et al
  • Organizer: ASCI2014
  • Place of Presentation: チェジュ島, 韓国
  • Year and Date: 2014-06-12 – 2014-06-14
• [Presentation] CT evaluation of myocardial extracellular volume in patients with chronic myocardial infarction: A novel approach for objective assessment of myocardial viability. (2014)
  • Author(s): Kurita Y., Kitagawa K., Ito T., et al
  • Organizer: ECR2014
  • Place of Presentation: Vienna, Austria
• [Presentation] Myocardial CT Delayed Enhancement using Targeted Spatial Frequency Filtration: Comparison with Conventional Axial Scan and MR Delayed Enhancement. (2013)
  • Author(s): Kurobe Y., Kitagawa K., Ito T, et al
  • Organizer: SCCT2013
  • Place of Presentation: Chicago, IL
• [Presentation] Regional and age-related variation of extracellular volume fraction in subjects without coronary artery disease assessed by cardiac CT (2013)
  • Author(s): Kitagawa K., Kurita Y., Ito T., et al
  • Organizer: SCCT2013
  • Place of Presentation: Montreal, Canada