• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of biomarker for cognitive impairment based on a novel fMRI method for brain connectivity mapping

Research Project

Project/Area Number 25461817
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

Aso Toshihiko  京都大学, 医学(系)研究科(研究院), 助教 (50397543)

Co-Investigator(Kenkyū-buntansha) URAYAMA Shin-ichi  京都大学, 大学院医学研究科, 助教 (10270729)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords機能的脳画像法 / 機能的MRI / 核磁気共鳴画像法 / 正常圧水頭症 / 認知症 / 脳血流 / 脳血管障害 / 独立成分分析 / 脳神経疾患 / 神経科学 / 脳内ネットワーク / 核磁気共鳴画像 / 結合性 / 安静時機能的MRI
Outline of Final Research Achievements

Non-invasive measurement of brain function has been highly dependent on neurovascular coupling, a mechanism which itself suffer contamination of blood flow variation. To probe both neural activity and blood circulation, we aimed to combine an optimized acquisition method with a novel data analysis technique that can separate perfusion from neuro-vascular coupling. For extracting the former, we established a new algorithm to BOLD-based blood tracking (lag mapping). There is practical advantage in finding such components when one observes or removes the blood circulation information in the data. We chose idiopathic normal pressure hydrocephalus, which is known as "treatable dememtia", because we can test the capability of the method to detect changes due to spinal tap test, a diagnostic and treatment procedure known to reverse the condition. Using lag mapping, we report the first observation of the precise location of abnormal venous drainage in this disease.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (19 results)

All 2016 2015 2014 2013 2012 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Default mode network connectivity in patients with idiopathic normal pressure hydrocephalus2016

    • Author(s)
      Khoo HM, Kishima H, Tani N, Oshino S, Maruo T, Hosomi K, Yanagisawa T, Kazui H, Watanabe Y, Shimokawa T, Aso T, Kawaguchi A, Yamashita F, Saitoh Y, Yoshimine T
    • Journal Title

      J Neurosurg.

      Volume: 124 Issue: 2 Pages: 350-358

    • DOI

      10.3171/2015.1.jns141633

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stimulus-driven changes in the direction of neural priming during visual word recognition2016

    • Author(s)
      Pas, M., Nakamura, K., Sawamoto, N., Aso, T., Fukuyama, H.
    • Journal Title

      Neuroimage

      Volume: 125 Pages: 428-436

    • DOI

      10.1016/j.neuroimage.2015.10.063

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Functional heterogeneity in the default mode network edges.2015

    • Author(s)
      Aso T, Fukuyama H
    • Journal Title

      Brain Connect

      Volume: 5(4) Issue: 4 Pages: 203-213

    • DOI

      10.1089/brain.2014.0256

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parkinson's disease patients showed delayed awareness of motor intention.2015

    • Author(s)
      Tabu H, Aso T, Matsuhashi M, Ueki Y, Takahashi R, Fukuyama H, Shibasaki H, Mima T
    • Journal Title

      Neurosci Res.

      Volume: in press Pages: 0-0

    • DOI

      10.1016/j.neures.2015.01.012

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional Inhomogeneity in Default Mode Network Edges2015

    • Author(s)
      Aso T, Fukuyama H
    • Journal Title

      Brain Connectivity

      Volume: 0 Pages: 0-0

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Comparison of diffusion-weighted fMRI and BOLD fMRI responses in a verbal working memory task.2013

    • Author(s)
      Aso, T., Urayama, S., Fukuyama, H., & Le Bihan, D.
    • Journal Title

      Neuroimage

      Volume: 67 Pages: 25-32

    • DOI

      10.1016/j.neuroimage.2012.11.005

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transcranial direct current stimulation changes human endowment effect.2013

    • Author(s)
      Votinov, M., Aso, T., Koganemaru, S., Fukuyama, H., & Mima, T.
    • Journal Title

      Neuroscience Research

      Volume: 76 Issue: 4 Pages: 251-256

    • DOI

      10.1016/j.neures.2013.05.007

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] MRI in epilepsy and migraine2013

    • Author(s)
      Aso, T.
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 53(11) Pages: 1097-9

    • NAID

      130004505347

    • Related Report
      2013 Research-status Report
  • [Journal Article] Internal structural changes in the hippocampus observed on 3-tesla MRI in patients with mesial temporal lobe epilepsy.2013

    • Author(s)
      Mitsueda-Ono, T., A. Ikeda, N. Sawamoto, T. Aso, T. Hanakawa, M. Kinoshita, R. Matsumoto, N. Mikuni, S. Amano, H. Fukuyama, and R. Takahashi
    • Journal Title

      Intern Med

      Volume: 52(8) Pages: 1097-9

    • NAID

      130003365993

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visual response of neurons in the lateral intraparietal area and saccadic reaction time during a visual detection task2012

    • Author(s)
      Tomohiro Tanaka, Satoshi Nishida, Toshihiko Aso, Tadashi Ogawa
    • Journal Title

      European Journal of Neuroscience

      Volume: in press Issue: 6 Pages: 942-56

    • DOI

      10.1111/ejn.12100

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 安静時機能的MRI画像による脳循環の評価2015

    • Author(s)
      麻生 俊彦
    • Organizer
      第26回日本老年医学会近畿地方会
    • Place of Presentation
      京都市
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] Venodynamic MRIによる脳血流の評価2015

    • Author(s)
      麻生 俊彦
    • Organizer
      第27回日本循環代謝学会総会
    • Place of Presentation
      富山市
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Assessment of the Reproducibility of BOLD signal-based Hemodynamic MRI2015

    • Author(s)
      Toshihiko Aso, Sei Nishida, Shin-ichi Urayama, Hidenao Fukuyam
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      トロント、カナダ
    • Year and Date
      2015-06-02
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] FMRIによるNIRS信号源の検証2014

    • Author(s)
      麻生俊彦
    • Organizer
      臨床神経生理学会
    • Place of Presentation
      福岡
    • Year and Date
      2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] A functional MRI study on thought suppression.2014

    • Author(s)
      Kiyonaka T, Aso, T
    • Organizer
      The 18th Association for the Scientific Study of Consciousness
    • Place of Presentation
      オーストラリア、ブリスベン
    • Year and Date
      2014-07-16 – 2014-07-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Brain imaging techniques in CNS disorders - Toward in vivo observation of neuron- glia interaction dynamics2014

    • Author(s)
      Aso T, Fukuyama H
    • Organizer
      DFG- JSPSシンポジウム
    • Place of Presentation
      ドイツ、ミュンヘン
    • Year and Date
      2014-06-29 – 2014-06-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 機能的MRIによる
皮質ネットワークの
実在性の検証2014

    • Author(s)
      麻生 俊彦、浦山 慎一、福山 秀直
    • Organizer
      第16回日本ヒト脳機能マッピング学会
    • Place of Presentation
      仙台市
    • Related Report
      2013 Research-status Report
  • [Presentation] Comparison of Spin-echo and Gradient-echo BOLD Signals in The Default Network2013

    • Author(s)
      Toshihiko Aso, Shin-ichi Urayama, Hidenao Fukuyama
    • Organizer
      The 19th Annual Meeting of the Organization for Human Brain Mapping
    • Place of Presentation
      Seattle, USA
    • Related Report
      2013 Research-status Report
  • [Remarks] 研究業績

    • URL

      http://hbrc.kuhp.kyoto-u.ac.jp/AnnualBulletin.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi