Optimal application of advanced CT technology for the diagnosis and management of lung cancer.

• Project/Area Number: 25461818
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: KUBO TAKESHI 京都大学, 医学(系)研究科(研究院), 助教 (20464216)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: エックス線 / ＣＴ / 肺癌 / Ｘ線線量低減 / Ｘ腺線量低減 / X線 / CT / 画像診断 / 悪性腫瘍

Outline of Final Research Achievements

Effectiveness of advanced area detector CT technology to lung cancer management was assessed in terms of motion analysis and radiation dose reduction. Kinematic assessment was shown to be feasible by applying CT iterative reconstruction method. Low dose CT images can be applicable without decrease in diagnostic accuracy of common abnormality found in chest CT.

Research Products

• [Journal Article] Is volumetric 3-dimensional computed tomography useful to predict histological tumour invasiveness? Analysis of 211 lesions of cT1N0M0 lung adenocarcinoma. (2016)
  • Author(s): Shikuma K, Menju T, Chen F, Kubo T, Muro S, Sumiyoshi S, Ohata K, Sowa T, Nakanishi T, Cho H, Neri S, Aoyama A, Sato T, Sonobe M, Date H.
  • Journal Title: Interact Cardiovasc Thorac Surg. Volume: 1 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Standard-dose vs. Low-dose CT protocols in the Evaluation of Localized Lung Lesions: Capability for Lesion Characterization. (2016)
  • Author(s): Kubo T, Ohno Y, Takenaka D, Nishino M, Gautam S, Sugimura K, Kauczor HU, Hatabu H.
  • Journal Title: European Journal of Radiology Open Volume: 3 Pages: 67-73
  • DOI: 10.1016/j.ejro.2016.03.002
  • Peer Reviewed / Open Access
• [Journal Article] Low dose chest CT protocol (50 mAs) as a routine protocol for comprehensive assessment of intrathoracic abnormality. (2016)
  • Author(s): Kubo T, Ohno Y, Nishino M, Lin PJ, Gautam S, Kauczor HU, Hatabu H
  • Journal Title: European Journal of Radiology Open Volume: 3 Pages: 86-94
  • DOI: 10.1016/j.ejro.2016.04.001
  • NAID: 120005997693
  • Peer Reviewed / Open Access
• [Journal Article] Impact of pretreatment interstitial lung disease on radiation pneumonitis and survival after stereotactic body radiation therapy for lung cancer. (2015)
  • Author(s): Ueki N, Matsuo Y, Togashi Y, Kubo T, Shibuya K, Iizuka Y, Mizowaki T, Togashi K, Mishima M, Hiraoka M.
  • Journal Title: J Thorac Oncol Volume: 10 Issue: 1 Pages: 116-25
  • DOI: 10.1097/jto.0000000000000359
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 多発結節影 (2015)
  • Author(s): 久保 武
  • Journal Title: 呼吸 Volume: 34 Pages: 473-478
• [Journal Article] Radiation dose reduction in chest CT--review of available options (2014)
  • Author(s): Kubo T, Ohno Y, Kauczor HU, Hatabu H
  • Journal Title: European Journal of Radiology Volume: 10 Issue: 10 Pages: 1953-61
  • DOI: 10.1016/j.ejrad.2014.06.033
  • Peer Reviewed
• [Journal Article] Pleuroparenchymal fibroelastosis and non-specific interstitial pneumonia: frequent pulmonary sequelae of haematopoietic stem cell transplantation (2014)
  • Author(s): Takeuchi Y, Miyagawa-Hayashino A, Chen F, Kubo T, Handa T, Date H, Haga H
  • Journal Title: Histopathology Volume: 66 Issue: 4 Pages: 536-44
  • DOI: 10.1111/his.12553
  • Peer Reviewed / Open Access
• [Journal Article] Association between polyclonal and mixed mycobacterial Mycobacterium avium complex infection and environmental exposure. (2014)
  • Author(s): Fujita K, Ito Y, Hirai T, Kubo T, Maekawa K, Togashi K, Ichiyama S, Mishima M.
  • Journal Title: Ann Am Thorac Soc. Volume: 11 Issue: 1 Pages: 45-53
  • DOI: 10.1513/annalsats.201309-297oc
  • Peer Reviewed
• [Journal Article] Prevalence and risk factors for chronic co-infection in pulmonary Mycobacterium avium complex disease (2014)
  • Author(s): Fujita K, Ito Y, Hirai T, Kubo T, Togashi K, Ichiyama S, Mishima M
  • Journal Title: BMJ open respiratory research Volume: 1 Issue: 1 Pages: e000050-e000050
  • DOI: 10.1136/bmjresp-2014-000050
  • Peer Reviewed / Open Access
• [Journal Article] The influence of environmental exposure on the response to antimicrobial treatment in pulmonary Mycobacterial avium complex disease (2014)
  • Author(s): Yutaka Ito, Toyohiro Hirai, Kohei Fujita, Takeshi Kubo, Koichi Maekawa, Satoshi Ichiyama, Kaori Togashi, Michiaki Mishima
  • Journal Title: BMC Infectious diseases Volume: 14 Issue: 1 Pages: 522-528
  • DOI: 10.1186/1471-2334-14-522
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Neutrophil gelatinase-associated lipocalin in idiopathic pulmonary fibrosis. (2014)
  • Author(s): Ikezoe K, Handa T, Mori K, Watanabe K, Tanizawa K, Aihara K, Tsuruyama T, Miyagawa-Hayashino A, Sokai A, Kubo T, Muro S, Nagai S, Hirai T, Chin K, Mishima M
  • Journal Title: Eur Respir J Volume: 43 Issue: 6 Pages: 1807-1809
  • DOI: 10.1183/09031936.00192613
  • Peer Reviewed
• [Journal Article] 早期肺癌の画像診断 (2014)
  • Author(s): 久保 武
  • Journal Title: 肺癌 Volume: 54 Pages: 854-861
  • NAID: 130004705043
• [Journal Article] The prognostic value of HRCT in myositis-associated interstitial lung disease. (2013)
  • Author(s): Tanizawa K, Handa T, Nakashima R, Kubo T, Hosono Y, Aihara K, Ikezoe K, Watanabe K, Taguchi Y, Hatta K, Oga T, Chin K, Nagai S, Mimori T, Mishima M
  • Journal Title: Respir Med. Volume: 107 Issue: 5 Pages: 745-752
  • DOI: 10.1016/j.rmed.2013.01.014
  • Peer Reviewed
• [Journal Article] High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease. (2013)
  • Author(s): Maekawa K, Ito Y, Oga T, Hirai T, Kubo T, Fujita K, Imai S, Niimi A, Chin K, Ichiyama S, Togashi K, Mishima M
  • Journal Title: The International Journal of Tuberculosis and Lung Disease Volume: 17 Issue: 6 Pages: 829-835
  • DOI: 10.5588/ijtld.12.0672
  • Peer Reviewed
• [Presentation] Pleural sliding mapping derived for detecting pleural adhesions. (2016)
  • Author(s): Ryo Sakamoto, Takeshi Kubo
  • Organizer: Asia Oceania Workshop of Pulmonary Functional Imaging.
  • Place of Presentation: Awaji Yumebutai International Conference Center, Awaji, Hyogo, Japan.
  • Year and Date: 2016-01-29
  • Int'l Joint Research
• [Presentation] Pleural Sliding Mapping Derived from 4DCT Can Predict Pleural Adhesions. (2015)
  • Author(s): Ryo Sakamoto, Koji Sakai, Mitsugu Omasa, Masatsugu Hamaji, Keita Nakagomi, Kaori Togashi, Takeshi Kubo,et al
  • Organizer: The 101th Annual Meeting of Radiological Society of North America (RSNA2015)
  • Place of Presentation: McCormick Place, Chicago, IL, United States.
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Temporal Subtraction Images Derived by Large Deformation Diffeomorphic Metric Mapping Facilitate Identification of Bone Metastases in Follow-up CT (2014)
  • Author(s): Sakamoto,R, Yakami,M, Fujimoto,K, Mori,S, Miller,M, Togashi,K, Nakagomi,K, Aoyama,G, Ceritoglu,C, Kubo,T, Emoto,Y, Sekiguchi,H, Sakai,K, Kawagishi,M, Iizuka,Y, Yamamoto,H
  • Organizer: Radiological Society of North America 2014 Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, United States
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] What are Essential Imaging Findings and Clinical Information for the Diagnosis of Lung Nodules? An Analysis Based on a Large Database of Thin-slice CT Image. (2014)
  • Author(s): Kubo,T, Aoyama,G, Sakamoto,R, Yakami,M, Fujimoto,K, Togashi,K, Emoto,Y, Sekiguchi,H, Sakai,K, Kawagishi,M, Iizuka,Y, Nakagomi,K, Chen,B, Yamamoto,H
  • Organizer: Radiological Society of North America 2014 Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, United States
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Detectability of PET/CT with 68Ga-DOTATOC in Sarcoidosis Patients (2014)
  • Author(s): Nobashi,T, Nakamoto,Y, Kubo,T, Nakatani,K, Koyasu,S, Togashi,K, Detectability of PET/CT with 68Ga-DOTATOC in Sarcoidosis Patients.
  • Organizer: Radiological Society of North America 2014 Scientific Assembly and Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, United States
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] サルコイドーシス患者におけるToll-like receptor 3 塩基多型の検討 (2014)
  • Author(s): 池添 浩平, 半田 知宏, 谷澤 公伸, 久保 武, 伊藤 功朗, 祖開 暁彦, 中塚 賀也, 長井 苑子, 泉 孝英, 三嶋 理晃
  • Organizer: 日本サルコイドーシス/肉芽腫性疾患学会総会
  • Place of Presentation: 新潟医療人育成センター、新潟市
  • Year and Date: 2014-11-01 – 2014-11-02
• [Presentation] わかりやすい胸部画像診断 (2014)
  • Author(s): 久保武
  • Organizer: 第24回日本呼吸ケア・リハビリテーション学会学術集会
  • Place of Presentation: 奈良100年会館、奈良市
  • Year and Date: 2014-10-24 – 2014-10-25
  • Invited
• [Presentation] COPDにおけるCT形態評価とOxygen-enhanced MRIによる機能評価の比較 (2014)
  • Author(s): 伏屋 芳紀, 室 繁郎, 佐藤 篤靖, 佐藤 晋, 平井 豊博, 三嶋 理晃, 富樫 かおり, 久保 武, 木戸 晶, 藤本 晃司, 高倉 京子, 草原 博志, 坂下 尚孝, 大野 良治
  • Organizer: 第54回 日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場、大阪市
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 間質性肺疾患を合併した多発性筋炎/皮膚筋炎患者における血清プロスタグランジンF2α代謝産物濃度 (2014)
  • Author(s): 中塚 賀也, 半田 知宏, 祖開 暁彦, 池添 浩平, 平井 豊博, 三嶋 理晃, 谷澤 公伸, 小賀 徹, 陳 和夫, 細野 裕司, 中嶋 蘭, 三森 経世, 久保 武, 田口 善夫, 八田 和弘
  • Organizer: 第54回 日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場、大阪市
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 推論理由を提示する肺結節診断支援システムの有用性 (2014)
  • Author(s): 坂本亮、八上全弘、久保武、藤本晃司、江本豊、関口博之、酒井晃二、青山岳人、川岸将実、飯塚義夫、山本裕之、富樫かおり
  • Organizer: 第６回呼吸機能イメージング研究会学術集会
  • Place of Presentation: 北海道大学学術交流会館、札幌市
• [Presentation] 胸部CTにおける肺結節診断の再現性と結節性状 (2013)
  • Author(s): 坂本亮、八上全弘、藤本晃司、久保武、青山岳人、川岸将実、関口博之、酒井晃二、江本豊、富樫かおり
  • Organizer: 第72回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜、横浜市
• [Presentation] Relationship between Characteristics of Pulmonary Nodules and Performance Improvement of Radiologists: Comparison between CADx with and without Reasoning (2013)
  • Author(s): Kubo, T, Aoyama G, Fujimoto K, Yakami M, Kawagishi M,Togashi K,Emoto Y, Sakamoto R, Iizuka Y, Sekiguchi H, Sakai K, Yamamoto H
  • Organizer: 99th Radiological Society of North America
  • Place of Presentation: McCormick Place, Chicago, United States
• [Presentation] 早期肺癌の診断 画像診断
  • Author(s): 久保武
  • Organizer: 第28回日本肺癌学会ワークショップ
  • Place of Presentation: 京都大学医学部芝欄会館 稲盛ホール、京都市
  • Invited
• [Presentation] アレルギー性肺疾患（好酸球性肺炎，過敏性肺臓炎，薬剤性肺障害）・膠原病肺
  • Author(s): 久保武
  • Organizer: 第49回日本医学放射線学会秋季臨床大会
  • Place of Presentation: 名古屋国際会議場、名古屋市
  • Invited