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Visualization of the deep perforating artery and related brain changes

Research Project

Project/Area Number 25461819
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

Okada Tomohisa  京都大学, 医学(系)研究科(研究院), 准教授 (30321607)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Akira  京都大学, 大学院医学研究科, 助教 (60525567)
KANAGAKI Mitsunori  京都大学, 大学院医学研究科, 助教 (50378676)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords深部灰白質穿通動脈 / MRアンギオグラフィ / レンズ核線条体動脈 / 高血圧 / 磁気共鳴画像 / 基底核穿通動脈 / TOF-MRA / FSBB-MRA / MRアンギオグラフィー / 深部灰白質穿通動脈枝 / FSBB / TOF
Outline of Final Research Achievements

This research targeted the perforating artery of the deep gray matter. Firstly, its visualization was successfully conducted using a new scan method of FSBB at 3T. The visualization was also confirmed on 7T. Secondly, its pathological changes caused by such factors as hypertension are under analysis now. Thirdly, for structural changes caused by the perforating artery, methodological validation was conducted on volumetry and T1 value quantitation. Diffusion tensor imaging was also conducted to investigate small structures in the brain. Moya-moya disease was selected as a representative case for a pathological condition related to the perforating artery and the investigational results was reported.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Voxel Based Analysis of Surgical Revascularization for Moyamoya Disease: Pre- and Postoperative SPECT Studies.2016

    • Author(s)
      Fushimi Y, Okada T, Takagi Y, Funaki T, Takahashi JC, Miyamoto S, Togashi K.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: e0148925-e0148925

    • DOI

      10.1371/journal.pone.0148925

    • NAID

      120005763395

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MP2RAGE for deep gray matter measurement of the brain: A comparative study with MPRAGE.2016

    • Author(s)
      Gosuke Okubo, Tomohisa Okada, Akira Yamamoto, Mitsunori Kanagaki, Yasutaka Fushimi, Tsutomu Okada, Katsuhisa Murata, and Kaori Togashi
    • Journal Title

      J Magn Reson Imaging

      Volume: 43(1) Issue: 1 Pages: 55-62

    • DOI

      10.1002/jmri.24960

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periventricular anastomosis in moyamoya disease: detecting fragile collateral vessels with MR angiography.2015

    • Author(s)
      Funaki T, Takahashi JC, Yoshida K, Takagi Y, Fushimi Y, Kikuchi T, Mineharu Y, Okada T, Morimoto T, Miyamoto S.
    • Journal Title

      Journal of Neurosurgery

      Volume: Nov 27 Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Visualization of lenticulostriate arteries at 3T: Optimization of slice-selective off-resonance sinc pulse-prepared TOF-MRA and its comparison with flow-sensitive black-blood MRA.2014

    • Author(s)
      Okuchi S, Okada T, Fujimoto K, Fushimi Y, Kido A, Yamamoto A, Kanagaki M, Dodo T, Mehemed TM, Miyazaki M, Zhou X, Togashi K.
    • Journal Title

      Academic Radiology

      Volume: 21 Issue: 6 Pages: 812-6

    • DOI

      10.1016/j.acra.2014.03.007

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Brain Morphometry Reproducibility Analysis between Longitudinal and Cross-sectional Processing.2015

    • Author(s)
      Maruguchi N, Fushimi Y, Okada T, Fujimoto K, Hinoda T, Yamamoto A, Okada T, Kido A, Sakashita N, Togashi K.
    • Organizer
      European Society of Magnetic Resonance in Medicine and Biology.
    • Place of Presentation
      Edinburgh, United Kingdom.
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MP2RAGE for deep gray matter measurement of the brain: A comparative study with MPRAGE.2015

    • Author(s)
      Okubo, G., T. Okada, A. Yamamoto, M. Kanagaki, Y. Fushimi, T. Okada, K. Murata, and K. Togashi
    • Organizer
      International Society of Magnetic Resonance in Medicine 2015
    • Place of Presentation
      Toronto, Canada.
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intra/Extra-cranial MRA2015

    • Author(s)
      Tomohisa Okada
    • Organizer
      Non-contrast-enhanced MRA ISMRM workshop 2015
    • Place of Presentation
      Long Beach, CA, USA.
    • Year and Date
      2015-03-06 – 2015-03-08
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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