Characterization of intratumoral hypovascular areas with PET and MRI

• Project/Area Number: 25461822
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Osaka University
• Principal Investigator: Tatsumi Mitsuaki 大阪大学, 医学部附属病院, 講師 (60397700)
• Co-Investigator(Kenkyū-buntansha): 金井 泰和 大阪大学, 医学系研究科, 寄附講座助教 (60397643)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: PET / 腫瘍 / 低血流

Outline of Final Research Achievements

Characteristics other than hypoxia in hypovascular areas inside the tumor were evaluated using images mainly on PET. Information on glucose metabolism was obtained from FDG PET. Association between increase in FDG uptake and decrease in blood flow was revealed in cases of primary liver tumors, and association between increase in FDG uptake and decrease in diffusion index from MR images was also clarified in pancreatic cancer cases. Intratumoral heterogeneity of FDG uptake was shown to be related to blood flow in pancreatic cancer, and showed the possible usefulness to predict treatment effect on chemotherapy and postoperative recurrence in esophageal cancer. Furthermore, texture analysis of intratumoral FDG uptake revealed that one texture feature allowed prediction of recurrence while it was not related to tumor volumes or degree of FDG uptake.

Research Products

• [Presentation] Prediction of treatment response and recurrence with texture analysis or volumetric parameters on FDG PET in patients with esophageal cancer receiving neoadjuvant chemotherapy and surgery (2016)
  • Author(s): Tatsumi M, Isohashi K, Kato H, Watabe T, Hatazawa J.
  • Organizer: Society of Nuclear Medicine's 63rd Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-06-11
  • Int'l Joint Research
• [Presentation] Associations of iodine content obtained from dual-energy contrast-enhanced CT and texture features or volumetric parameters on FDG PET in pancreatic cancer (2015)
  • Author(s): Tatsumi M, Sakane M, Onishi H, Isohashi K, Ishibashi M, Hatazawa J.
  • Organizer: Society of Nuclear Medicine's 62nd Annual Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2015-06-06
  • Int'l Joint Research
• [Presentation] Prediction of Treatment Response and Recurrence with SUV-volume Histogram Analysis on FDG PET/CT in Patients with Esophageal Cancer Receiving Neoadjuvant Chemotherapy and Surgery. (2014)
  • Author(s): Tatsumi M, Yanagawa M, Watabe T, Kim T, Tomiyama N, Hatazawa J.
  • Organizer: The 100th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2014).
  • Place of Presentation: Chicago, USA
  • Year and Date: 2014-11-30 – 2014-12-05
• [Presentation] Association between enhancement patterns on dynamic contrast-enhanced CT/MRI and FDG PET-CT findings in primary liver tumors. (2013)
  • Author(s): Tatsumi M, Sakane M, Kim T, Onishi M, Hori M, Isohashi K, Shimosegawa E, Tomiyama N, Hatazawa J.
  • Organizer: The 99th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA 2013).
  • Place of Presentation: Chicago, USA